Biomedical Technology, Год журнала: 2024, Номер 9, С. 100068 - 100068
Опубликована: Дек. 25, 2024
Язык: Английский
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101531 - 101531
Опубликована: Фев. 5, 2025
Three-dimensional (3D) printing technology has shown significant promise in the medical field, particularly orthopedics, prosthetics, tissue engineering, and pharmaceutical preparations. This review focuses on innovative application of 3D addressing challenges osteonecrosis femoral head (ONFH). Unlike traditional hip replacement surgery, which is often suboptimal for younger patients, offers precise localization necrotic areas ability to create personalized implants. By integrating advanced biomaterials, this a promising strategy approach early hip-preserving treatments. Additionally, 3D-printed bone engineering scaffolds can mimic natural environment, promoting regeneration vascularization. In future, potential extends combining with artificial intelligence optimizing treatment plans, developing materials enhanced bioactivity compatibility, translating these innovations from laboratory clinical practice. demonstrates how uniquely addresses critical ONFH treatment, including insufficient vascularization, poor mechanical stability, limited long-term success conventional therapies. introducing gradient porous scaffolds, bioactive material coatings, AI-assisted design, work outlines novel strategies improve interventions. These advancements not only enhance efficacy but also pave way findings into applications.
Язык: Английский
Процитировано
2
Food Chemistry, Год журнала: 2025, Номер 471, С. 142828 - 142828
Опубликована: Янв. 9, 2025
Язык: Английский
Процитировано
1
Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13
Опубликована: Фев. 12, 2025
Significant progress has been made in regenerative medicine for skin repair and rejuvenation. This review examines core technologies including stem cell therapy, bioengineered substitutes, platelet-rich plasma (PRP), exosome-based therapies, gene editing techniques like CRISPR. These methods hold promise treating a range of conditions, from chronic wounds burns to age-related changes genetic disorders. Challenges remain optimizing these therapies broader accessibility ensuring long-term safety efficacy.
Язык: Английский
Процитировано
1
Regenerative Biomaterials, Год журнала: 2025, Номер 12
Опубликована: Янв. 1, 2025
Abstract Neurological injuries and diseases are a leading cause of disability worldwide, underscoring the urgent need for effective therapies. Neural regaining enhancement therapies seen as most promising strategies restoring neural function, offering hope individuals affected by these conditions. Despite their promise, path from animal research to clinical application is fraught with challenges. Neuroengineering, particularly through use biomaterials, has emerged key field that paving way innovative solutions It seeks understand treat neurological disorders, unravel nature consciousness, explore mechanisms memory brain’s relationship behavior, tissue engineering, interfaces targeted drug delivery systems. These including both natural synthetic types, designed replicate cellular environment brain, thereby facilitating repair. This review aims provide comprehensive overview biomaterials in neuroengineering, highlighting functional across basic practice. covers recent developments biomaterial-based products, 2D 3D bioprinted scaffolds cell organoid culture, brain-on-a-chip systems, biomimetic electrodes brain–computer interfaces. also explores artificial synapses networks, discussing applications modeling microenvironments repair regeneration, modulation manipulation integration traditional Chinese medicine. serves guide role advancing neuroengineering solutions, providing insights into ongoing efforts bridge gap between innovation application.
Язык: Английский
Процитировано
1
Regenesis repair rehabilitation., Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
Bioengineering, Год журнала: 2025, Номер 12(3), С. 230 - 230
Опубликована: Фев. 24, 2025
In recent times, with the need for a reduction, refinement, and replacement of in vivo animal testing, there has been an increasing demand use relevant vitro human cell systems drug development. There is also great skin tissue various wounds burns. Furthermore, cell-based can be used to investigate side effects (toxicity irritation) penetration topical preparations. this study, exploratory experiments were performed produce artificial epidermis using two hydrogel scaffolds, alginate GelMA C. The amount keratinocytes added matrix (10–50–100 × 106/mL) duration maturation (fresh, 1–3–4 weeks) optimized extensive study. behavior structure hydrogels functionally morphologically assessed. permeability order caffeine tested barriers was following: > C cellulose acetate membrane rat skin. It concluded that provides more favorable environment survival differentiation (as demonstrated by histology immunohistochemistry) than alginate. 3-week incubation 50 106/mL number proved most beneficial given system. This study data first time on multifactorial optimization potential substitutes manufacturing. these results engineering, fabricated preparations must biocompatibility from physical mechanical point views.
Язык: Английский
Процитировано
0
Bioengineering, Год журнала: 2025, Номер 12(3), С. 251 - 251
Опубликована: Март 1, 2025
Perhaps the most innovative branch of medicine is represented by regenerative medicine. It deals with regenerating or replacing tissues damaged disease aging. The frontier this bioprinting. This technology aims to reconstruct tissues, organs, and anatomical structures, such as those in head neck region. would mean revolutionizing therapeutic surgical approaches management multiple conditions which a conspicuous amount tissue lost. application bioprinting for reconstruction areas removed due presence malignancy represent revolutionary new step personalized precision review investigate recent advances use biomaterials structures head–neck region, particularly oral cavity. characteristics properties each biomaterial currently available will be presented, well their potential applicability affected neoplasia after surgery. In addition, study examine current limitations challenges analyze future prospects maxillofacial
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101701 - 101701
Опубликована: Март 1, 2025
Three-dimensional (3D) bioprinting of hydrogels allows embedded cells to be patterned and hosted in an extracellular matrix (ECM)-mimicking environment. This method shows great promise for the engineering complex tissues on account facile spatial control over materials within printed constructs. Hydrogels, which represent extensively explored employed biomaterials 3D bioprinting, are characterized by both their high water content swelling behavior. Post-printing inevitably alters geometrical mechanical properties features, thus causing a deviation from original design affecting cellular function tissue structure. Despite substantial effort being dedicated development non-swelling hydrogels, application encapsulation living is yet realized, owing limitations imposed often tedious material syntheses network structures. Herein, we describe new type hydrogel based fully cold fish gelatin (cfGel-Hydrogel) consisting only single formed via thiol-ene "click" chemistry. We show that such cfGel-Hydrogels enable patterning shape-retaining mechanically robust matrix. These negligible (<2 %) under physiologically relevant conditions (simulated 37 °C PBS buffer), while also able withstand large cyclic deformations (80 % compressive strain) dissipating around 40 loading energy. Human dermal fibroblast (HDF)-laden could fabricated extrusion-based printing, allowing vitro culturing constructs, offering opportunities hydrogel-based applications regenerative medicine.
Язык: Английский
Процитировано
0
Advanced Materials Technologies, Год журнала: 2025, Номер unknown
Опубликована: Апрель 24, 2025
Abstract 3D bioprinting has emerged as a transformative technology in tissue engineering, significantly impacting the creation of patient‐specific tissues to enhance clinical outcomes. Despite its rapid advancement, translating this from bench bedside remains critical need. New approaches, such handheld printers or robotic arm‐driven situ biofabrication techniques, have promising alternatives. These advancements enable reconstruction damaged directly on living anatomical structures, offering adaptability and precise matching affected area. The integration biomaterials, engineering principles, digital technologies, particularly robotics, garnered substantial interest both academic industrial sectors, highlighting potential for applications. However, challenges persist, including refining bioink formulations, adjusting mechanical properties, facilitating crosslinking, accurately mimicking extracellular matrix. This review explores cutting‐edge frontier regeneration, utilizing arm‐assisted printers. It systematically examines relative advantages, disadvantages, challenges, prospects it transitions side bed side.
Язык: Английский
Процитировано
0
Polymers, Год журнала: 2025, Номер 17(9), С. 1263 - 1263
Опубликована: Май 6, 2025
For organ-on-a-chip (OoC) engineering, the use of biocompatible coatings and materials is not only recommended but essential. Extracellular matrix (ECM) components are commonly used as due to their effects on cell orientation, protein expression, differentiation, adhesion. Among most frequently collagen, fibronectin, Matrigel, according specific type intended OoC application. Additionally, such polydimethylsiloxane (PDMS), thermoplastics, chitosan, alginate serve scaffolding biomechanical properties biocompatibility. Here, we discuss some employed coating techniques, including SAMs, dip coating, spin microcontact printing, 3D bioprinting, each offering advantages drawbacks. Current challenges comprise enhancing biocompatibility, exploring novel materials, improving scalability reproducibility.
Язык: Английский
Процитировано
0