3D Printing of Biocompatible and Antibacterial Silica–Silk–Chitosan-Based Hybrid Aerogel Scaffolds Loaded with Propolis DOI

Akbar Vaseghi,

Majid Sadeghizadeh, Marc Herb

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

The aim of this study is to design a therapeutic enhanced three-dimensional (3D) silk fibroin (SF)-based scaffold containing propolis (Ps)-loaded chitosan (CH) nanocarriers. To aim, we initially synthesized hybrid gel-based ink by synergistic sol-gel and self-assembly approach then processed the resulting gels microextrusion-based 3D printing followed supercritical drying obtain aerogel scaffolds. Ps was utilized enhance final scaffold's bactericidal efficacy cell responsiveness. For synthesis scaffold, two loading methods (in preprint postprinting steps) were investigated in order optimize drug quantities maximize antibacterial properties scaffold. In step, silica-oxidized SF (SFO)-CH hydrogel printed into construct with an interconnected porous structure, then, loaded construct. method, PS incorporated hydrolyzed silane solution prior gelation. morphological studies demonstrate that addition encapsulated CH nanoparticles (NPs) improved porosity developed rheological analysis designed gel without release kinetics studied. antimicrobial results show Ps-loaded scaffolds step exhibited superior activity against

Language: Английский

3D bioprinting: Advancing the future of food production layer by layer DOI Creative Commons

Nisansala Chandimali,

Seon-Gyeong Bak,

Eun Hyun Park

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 471, P. 142828 - 142828

Published: Jan. 9, 2025

Language: Английский

Citations

1
Advancements in 3D Printing Technologies for Personalized Treatment of Osteonecrosis of the Femoral Head DOI Creative Commons
Tingting Chen,

Lincong Luo,

Jiaying Li

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101531 - 101531

Published: Feb. 5, 2025

Three-dimensional (3D) printing technology has shown significant promise in the medical field, particularly orthopedics, prosthetics, tissue engineering, and pharmaceutical preparations. This review focuses on innovative application of 3D addressing challenges osteonecrosis femoral head (ONFH). Unlike traditional hip replacement surgery, which is often suboptimal for younger patients, offers precise localization necrotic areas ability to create personalized implants. By integrating advanced biomaterials, this a promising strategy approach early hip-preserving treatments. Additionally, 3D-printed bone engineering scaffolds can mimic natural environment, promoting regeneration vascularization. In future, potential extends combining with artificial intelligence optimizing treatment plans, developing materials enhanced bioactivity compatibility, translating these innovations from laboratory clinical practice. demonstrates how uniquely addresses critical ONFH treatment, including insufficient vascularization, poor mechanical stability, limited long-term success conventional therapies. introducing gradient porous scaffolds, bioactive material coatings, AI-assisted design, work outlines novel strategies improve interventions. These advancements not only enhance efficacy but also pave way findings into applications.

Language: Английский

Citations

1
Advances in regenerative medicine-based approaches for skin regeneration and rejuvenation DOI Creative Commons

Nathalia Silva Dutra Alves,

Gustavo Roncoli Reigado,

Mayara Santos

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 12, 2025

Significant progress has been made in regenerative medicine for skin repair and rejuvenation. This review examines core technologies including stem cell therapy, bioengineered substitutes, platelet-rich plasma (PRP), exosome-based therapies, gene editing techniques like CRISPR. These methods hold promise treating a range of conditions, from chronic wounds burns to age-related changes genetic disorders. Challenges remain optimizing these therapies broader accessibility ensuring long-term safety efficacy.

Language: Английский

Citations

0
Biomaterials for neuroengineering: Applications and challenges DOI Creative Commons

Huanghui Wu,

E.J. Feng,

Huazong Yin

et al.

Regenerative Biomaterials, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 1, 2025

Abstract Neurological injuries and diseases are a leading cause of disability worldwide, underscoring the urgent need for effective therapies. Neural regaining enhancement therapies seen as most promising strategies restoring neural function, offering hope individuals affected by these conditions. Despite their promise, path from animal research to clinical application is fraught with challenges. Neuroengineering, particularly through use biomaterials, has emerged key field that paving way innovative solutions It seeks understand treat neurological disorders, unravel nature consciousness, explore mechanisms memory brain’s relationship behavior, tissue engineering, interfaces targeted drug delivery systems. These including both natural synthetic types, designed replicate cellular environment brain, thereby facilitating repair. This review aims provide comprehensive overview biomaterials in neuroengineering, highlighting functional across basic practice. covers recent developments biomaterial-based products, 2D 3D bioprinted scaffolds cell organoid culture, brain-on-a-chip systems, biomimetic electrodes brain–computer interfaces. also explores artificial synapses networks, discussing applications modeling microenvironments repair regeneration, modulation manipulation integration traditional Chinese medicine. serves guide role advancing neuroengineering solutions, providing insights into ongoing efforts bridge gap between innovation application.

Language: Английский

Citations

0
In Vitro Functional and Structural Evaluation of Low-Complexity Artificial Human Epidermis for 3D Tissue Engineering DOI Creative Commons
Dorottya Kocsis, Dániel Sztankovics, Liza Józsa

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(3), P. 230 - 230

Published: Feb. 24, 2025

In recent times, with the need for a reduction, refinement, and replacement of in vivo animal testing, there has been an increasing demand use relevant vitro human cell systems drug development. There is also great skin tissue various wounds burns. Furthermore, cell-based can be used to investigate side effects (toxicity irritation) penetration topical preparations. this study, exploratory experiments were performed produce artificial epidermis using two hydrogel scaffolds, alginate GelMA C. The amount keratinocytes added matrix (10–50–100 × 106/mL) duration maturation (fresh, 1–3–4 weeks) optimized extensive study. behavior structure hydrogels functionally morphologically assessed. permeability order caffeine tested barriers was following: > C cellulose acetate membrane rat skin. It concluded that provides more favorable environment survival differentiation (as demonstrated by histology immunohistochemistry) than alginate. 3-week incubation 50 106/mL number proved most beneficial given system. This study data first time on multifactorial optimization potential substitutes manufacturing. these results engineering, fabricated preparations must biocompatibility from physical mechanical point views.

Language: Английский

Citations

0
Regenerative Medicine in Plastic Surgery: The Role of Stem Cells and Bioprinting DOI Creative Commons
Kirolos Eskandar

Regenesis repair rehabilitation., Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
The Properties and Applicability of Bioprinting in the Field of Maxillofacial Surgery DOI Creative Commons
Luca Michelutti, Alessandro Tel, Massimo Robiony

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(3), P. 251 - 251

Published: March 1, 2025

Perhaps the most innovative branch of medicine is represented by regenerative medicine. It deals with regenerating or replacing tissues damaged disease aging. The frontier this bioprinting. This technology aims to reconstruct tissues, organs, and anatomical structures, such as those in head neck region. would mean revolutionizing therapeutic surgical approaches management multiple conditions which a conspicuous amount tissue lost. application bioprinting for reconstruction areas removed due presence malignancy represent revolutionary new step personalized precision review investigate recent advances use biomaterials structures head–neck region, particularly oral cavity. characteristics properties each biomaterial currently available will be presented, well their potential applicability affected neoplasia after surgery. In addition, study examine current limitations challenges analyze future prospects maxillofacial

Language: Английский

Citations

0
Mechanically robust non-swelling cold water fish gelatin hydrogels for 3D Bioprinting DOI Creative Commons

Tobias Hammer,

Ke Yang,

Tobias Spirig

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101701 - 101701

Published: March 1, 2025

Three-dimensional (3D) bioprinting of hydrogels allows embedded cells to be patterned and hosted in an extracellular matrix (ECM)-mimicking environment. This method shows great promise for the engineering complex tissues on account facile spatial control over materials within printed constructs. Hydrogels, which represent extensively explored employed biomaterials 3D bioprinting, are characterized by both their high water content swelling behavior. Post-printing inevitably alters geometrical mechanical properties features, thus causing a deviation from original design affecting cellular function tissue structure. Despite substantial effort being dedicated development non-swelling hydrogels, application encapsulation living is yet realized, owing limitations imposed often tedious material syntheses network structures. Herein, we describe new type hydrogel based fully cold fish gelatin (cfGel-Hydrogel) consisting only single formed via thiol-ene "click" chemistry. We show that such cfGel-Hydrogels enable patterning shape-retaining mechanically robust matrix. These negligible (<2 %) under physiologically relevant conditions (simulated 37 °C PBS buffer), while also able withstand large cyclic deformations (80 % compressive strain) dissipating around 40 loading energy. Human dermal fibroblast (HDF)-laden could fabricated extrusion-based printing, allowing vitro culturing constructs, offering opportunities hydrogel-based applications regenerative medicine.

Language: Английский

Citations

0
Current status and challenges of shape memory scaffolds in biomedical applications DOI Creative Commons
Haoming Wu,

Shuhao Yang,

Jiuhong Li

et al.

MedComm – Biomaterials and Applications, Journal Year: 2024, Volume and Issue: 3(3)

Published: Sept. 1, 2024

Abstract The rapid evolution of clinical medicine, materials science, and regenerative medicine has rendered traditional implantable scaffolds inadequate for addressing the complex therapeutic demands various diseases. Currently, in practice are mainly made metal, with disadvantages high stiffness, poor toughness, low deformation. This paper offers a thorough review shape memory (SMSs), emphasizing their distinctive self‐recovery adaptive functionalities that enhance compatibility injured tissues, surpassing capabilities conventional metallic biomaterials. It delves into limitations current requisite performance metrics effective implants outlines essential fabrication methods SMSs. Moreover, we enumerate biomedical applications SMMs different response types, including thermology‐responsive, water‐responsive, light‐responsive. discussion extends to burgeoning SMSs engineering, utility bone tissue cardiovascular stenting, tubular structures, cardiac patches, which underscore potential minimally invasive procedures dynamic interactions. concludes an analysis challenges prospects, providing valuable insights developing applying sector.

Language: Английский

Citations

1
Advancements and Applications of Three-dimensional Printing Technology in Surgery DOI Creative Commons

Sri Lakshmi Devi Kanumilli,

Bhanu Prasad Kosuru,

Faiza Shaukat

et al.

Journal of Medical Physics, Journal Year: 2024, Volume and Issue: 49(3), P. 319 - 325

Published: July 1, 2024

Three-dimensional (3D) printing technology has revolutionized surgical practices, offering precise solutions for planning, education, and patient care. Surgeons now wield tangible, patient-specific 3D models derived from imaging data, allowing meticulous presurgical planning. These enhance precision, reduce operative times, minimize complications, ultimately improving outcomes. The also serves as a powerful educational tool, providing hands-on learning experiences medical professionals clearer communication with patients their families. Despite its advantages, challenges such model accuracy material selection exist. Ongoing advancements, including bioactive materials artificial intelligence integration, promise to further printing’s impact. future of in surgery holds potential regenerative medicine, increased global accessibility, collaboration through telemedicine. Interdisciplinary between engineering fields is crucial responsible innovative use this technology.

Language: Английский

Citations

1