A facile nanopattern modification of silk fibroin electrospun scaffold and corresponding impact on cell proliferation and osteogenesis DOI Creative Commons
Xiaojiao Liu,

Qinjun Ouyang,

Xiang Yao

и другие.

Regenerative Biomaterials, Год журнала: 2024, Номер 11

Опубликована: Янв. 1, 2024

Abstract As a well-known natural protein biomaterial, silk fibroin (SF) has shown broad application prospects in typical biomedical fields. However, the mostly used SF from Bombyx mori silkworm lacks specific cell adhesion sites and other bioactive peptide sequences, there is still significant room for further improvement of their biological functions. Therefore, it crucial to develop facile effective modification strategy this widely researched biomaterial. In study, electrospun scaffold been chosen as air plasma etching adopted nanopattern promote its Results demonstrated that could feasibly effectively create nano-island-like patterns on complex surface scaffolds, detailed features be easily regulated by adjusting time. addition, mesenchymal stem responses have illustrated significantly regulate corresponding behaviors. Compared with non-etched scaffold, 10 min-etched scaffolds (10E scaffold) promoted proliferation osteogenic differentiation. Moreover, 10E also confirmed accelerate vascularization ectopic osteogenesis vivo using rat subcutaneous implantation model. mentioned promoting effects would weakened or even counteracted increase conclusion, great potential Thus, provided useful guidance excellent SF-based suitable bone tissue engineering.

Язык: Английский

Process Optimization for Coaxial Extrusion-Based Bioprinting: A Comprehensive Analysis of Material Behavior, Structural Precision, and Cell Viability DOI

Jiarun Sun,

Youping Gong,

Yuchen He

и другие.

Additive manufacturing, Год журнала: 2025, Номер unknown, С. 104682 - 104682

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Biomaterials for neuroengineering: Applications and challenges DOI Creative Commons

Huanghui Wu,

E.J. Feng,

Huazong Yin

и другие.

Regenerative Biomaterials, Год журнала: 2025, Номер 12

Опубликована: Янв. 1, 2025

Abstract Neurological injuries and diseases are a leading cause of disability worldwide, underscoring the urgent need for effective therapies. Neural regaining enhancement therapies seen as most promising strategies restoring neural function, offering hope individuals affected by these conditions. Despite their promise, path from animal research to clinical application is fraught with challenges. Neuroengineering, particularly through use biomaterials, has emerged key field that paving way innovative solutions It seeks understand treat neurological disorders, unravel nature consciousness, explore mechanisms memory brain’s relationship behavior, tissue engineering, interfaces targeted drug delivery systems. These including both natural synthetic types, designed replicate cellular environment brain, thereby facilitating repair. This review aims provide comprehensive overview biomaterials in neuroengineering, highlighting functional across basic practice. covers recent developments biomaterial-based products, 2D 3D bioprinted scaffolds cell organoid culture, brain-on-a-chip systems, biomimetic electrodes brain–computer interfaces. also explores artificial synapses networks, discussing applications modeling microenvironments repair regeneration, modulation manipulation integration traditional Chinese medicine. serves guide role advancing neuroengineering solutions, providing insights into ongoing efforts bridge gap between innovation application.

Язык: Английский

Процитировано

0
Five-In-One Hydrogel Integrating Bacteriostasis, Self-Healing Capability, Growth Factor Release, Electrical Stimulation, and Photothermal Stimulation Tailored for Complex Wound Repair DOI
Simin Lai,

Chenxi Shi,

Liting Yuan

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Май 22, 2025

Complex wound management remains a significant global challenge, and the development of multifunctional dressings that can effectively promote healing an urgent clinical need. Herein, kind hydrogel dressing combines bacteriostasis, self-healing capability, growth factor release, electrical stimulation, photothermal stimulation is developed. This generated by adding protocatechualdehyde (protocatechuic aldehyde (PA)), short core-shell fibers loading with platelet-rich-plasma (platelet-rich plasma fibers), polydopamine-coated carbon nanotubes (PDA@CNTs) into quaternary ammonium chitosan (QCS) solution to form shear-reversibly cross-linked QCS/PA/PDA@CNTs-PRP hydrogel. The obtained hydrogels possess impressive properties, including high swelling capacity (445-852%), strong adhesion ability (16.4-36.7 kPa), ability, injectability, conductivity (0.24-0.46 S/m), properties. Notably, under near-infrared irradiation, exhibits highly efficient bactericidal activity. In vitro experiments demonstrated excellent biocompatibility anti-inflammatory capability as well its stimulate cell proliferation, migration, tubule formation. Moreover, in vivo studies further confirmed additional assistance light promotes epithelization, angiogenesis, collagen deposition. Consequently, this provides promising therapeutic strategy for complex healing.

Язык: Английский

Процитировано

0
A facile nanopattern modification of silk fibroin electrospun scaffold and corresponding impact on cell proliferation and osteogenesis DOI Creative Commons
Xiaojiao Liu,

Qinjun Ouyang,

Xiang Yao

и другие.

Regenerative Biomaterials, Год журнала: 2024, Номер 11

Опубликована: Янв. 1, 2024

Abstract As a well-known natural protein biomaterial, silk fibroin (SF) has shown broad application prospects in typical biomedical fields. However, the mostly used SF from Bombyx mori silkworm lacks specific cell adhesion sites and other bioactive peptide sequences, there is still significant room for further improvement of their biological functions. Therefore, it crucial to develop facile effective modification strategy this widely researched biomaterial. In study, electrospun scaffold been chosen as air plasma etching adopted nanopattern promote its Results demonstrated that could feasibly effectively create nano-island-like patterns on complex surface scaffolds, detailed features be easily regulated by adjusting time. addition, mesenchymal stem responses have illustrated significantly regulate corresponding behaviors. Compared with non-etched scaffold, 10 min-etched scaffolds (10E scaffold) promoted proliferation osteogenic differentiation. Moreover, 10E also confirmed accelerate vascularization ectopic osteogenesis vivo using rat subcutaneous implantation model. mentioned promoting effects would weakened or even counteracted increase conclusion, great potential Thus, provided useful guidance excellent SF-based suitable bone tissue engineering.

Язык: Английский

Процитировано

3