A facile nanopattern modification of silk fibroin electrospun scaffold and corresponding impact on cell proliferation and osteogenesis DOI Creative Commons
Xiaojiao Liu,

Qinjun Ouyang,

Xiang Yao

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Abstract As a well-known natural protein biomaterial, silk fibroin (SF) has shown broad application prospects in typical biomedical fields. However, the mostly used SF from Bombyx mori silkworm lacks specific cell adhesion sites and other bioactive peptide sequences, there is still significant room for further improvement of their biological functions. Therefore, it crucial to develop facile effective modification strategy this widely researched biomaterial. In study, electrospun scaffold been chosen as air plasma etching adopted nanopattern promote its Results demonstrated that could feasibly effectively create nano-island-like patterns on complex surface scaffolds, detailed features be easily regulated by adjusting time. addition, mesenchymal stem responses have illustrated significantly regulate corresponding behaviors. Compared with non-etched scaffold, 10 min-etched scaffolds (10E scaffold) promoted proliferation osteogenic differentiation. Moreover, 10E also confirmed accelerate vascularization ectopic osteogenesis vivo using rat subcutaneous implantation model. mentioned promoting effects would weakened or even counteracted increase conclusion, great potential Thus, provided useful guidance excellent SF-based suitable bone tissue engineering.

Language: Английский

Process Optimization for Coaxial Extrusion-Based Bioprinting: A Comprehensive Analysis of Material Behavior, Structural Precision, and Cell Viability DOI

Jiarun Sun,

Youping Gong,

Yuchen He

et al.

Additive manufacturing, Journal Year: 2025, Volume and Issue: unknown, P. 104682 - 104682

Published: Jan. 1, 2025

Language: Английский

Citations

1
Biomaterials for neuroengineering: Applications and challenges DOI Creative Commons

Huanghui Wu,

E.J. Feng,

Huazong Yin

et al.

Regenerative Biomaterials, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 1, 2025

Abstract Neurological injuries and diseases are a leading cause of disability worldwide, underscoring the urgent need for effective therapies. Neural regaining enhancement therapies seen as most promising strategies restoring neural function, offering hope individuals affected by these conditions. Despite their promise, path from animal research to clinical application is fraught with challenges. Neuroengineering, particularly through use biomaterials, has emerged key field that paving way innovative solutions It seeks understand treat neurological disorders, unravel nature consciousness, explore mechanisms memory brain’s relationship behavior, tissue engineering, interfaces targeted drug delivery systems. These including both natural synthetic types, designed replicate cellular environment brain, thereby facilitating repair. This review aims provide comprehensive overview biomaterials in neuroengineering, highlighting functional across basic practice. covers recent developments biomaterial-based products, 2D 3D bioprinted scaffolds cell organoid culture, brain-on-a-chip systems, biomimetic electrodes brain–computer interfaces. also explores artificial synapses networks, discussing applications modeling microenvironments repair regeneration, modulation manipulation integration traditional Chinese medicine. serves guide role advancing neuroengineering solutions, providing insights into ongoing efforts bridge gap between innovation application.

Language: Английский

Citations

0
A facile nanopattern modification of silk fibroin electrospun scaffold and corresponding impact on cell proliferation and osteogenesis DOI Creative Commons
Xiaojiao Liu,

Qinjun Ouyang,

Xiang Yao

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Abstract As a well-known natural protein biomaterial, silk fibroin (SF) has shown broad application prospects in typical biomedical fields. However, the mostly used SF from Bombyx mori silkworm lacks specific cell adhesion sites and other bioactive peptide sequences, there is still significant room for further improvement of their biological functions. Therefore, it crucial to develop facile effective modification strategy this widely researched biomaterial. In study, electrospun scaffold been chosen as air plasma etching adopted nanopattern promote its Results demonstrated that could feasibly effectively create nano-island-like patterns on complex surface scaffolds, detailed features be easily regulated by adjusting time. addition, mesenchymal stem responses have illustrated significantly regulate corresponding behaviors. Compared with non-etched scaffold, 10 min-etched scaffolds (10E scaffold) promoted proliferation osteogenic differentiation. Moreover, 10E also confirmed accelerate vascularization ectopic osteogenesis vivo using rat subcutaneous implantation model. mentioned promoting effects would weakened or even counteracted increase conclusion, great potential Thus, provided useful guidance excellent SF-based suitable bone tissue engineering.

Language: Английский

Citations

1