Why study human embryo development?
Developmental Biology,
Год журнала:
2024,
Номер
509, С. 43 - 50
Опубликована: Фев. 5, 2024
Understanding
the
processes
and
mechanisms
underlying
early
human
embryo
development
has
become
an
increasingly
active
important
area
of
research.
It
potential
for
insights
into
clinical
issues
such
as
pregnancy
loss,
origins
congenital
anomalies
developmental
adult
disease,
well
fundamental
biology.
Improved
culture
systems
preimplantation
embryos,
combined
with
new
tools
single
cell
genomics
live
imaging,
are
providing
similarities
differences
between
mouse
development.
However,
access
to
material
is
still
restricted
extended
embryos
regulatory
ethical
concerns.
Stem
cell-derived
models
different
phases
can
potentially
overcome
these
limitations
provide
a
scalable
source
explore
postimplantation
stages
To
date,
clearly
incomplete
replicas
normal
but
future
technological
improvements
be
envisaged.
The
environment
studies
remains
fully
resolved.
Язык: Английский
Balancing Technology, Ethics, and Society: A Review of Artificial Intelligence in Embryo Selection
Information,
Год журнала:
2025,
Номер
16(1), С. 18 - 18
Опубликована: Янв. 2, 2025
The
introduction
of
artificial
intelligence
(AI)
in
embryo
selection
during
vitro
fertilization
presents
distinct
ethical
and
societal
challenges
compared
to
the
general
implementation
AI
healthcare.
This
narrative
review
examines
perspectives
potential
implications
implementing
AI-driven
selection.
literature
reveals
that
some
authors
perceive
as
an
extension
a
technocratic
paradigm
commodifies
embryos,
considering
any
methods
undermine
dignity
human
life.
Others,
instead,
contend
prioritizing
embryos
with
highest
viability
is
morally
permissible
while
cautioning
against
discarding
based
solely
on
unproven
assessments.
reviewed
identified
further
concerns
associated
this
technique,
including
possible
bias
criteria,
lack
transparency
black-box
algorithms,
risks
“machine
paternalism”
replacing
judgment,
privacy
issues
sensitive
fertility
data,
equity
access,
maintaining
human-centered
care.
These
findings,
along
results
only
randomized
controlled
trial
available,
suggest
clinical
practice
not
currently
scientifically
ethically
justified.
Implementing
deploying
responsible
would
be
feasible
if
raised
are
adequately
addressed.
Язык: Английский
Opportunities and limitations of introducing artificial intelligence technologies into reproductive medicine
Obstetrics Gynecology and Reproduction,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 14, 2025
Given
the
increasing
problem
of
infertility
in
Russian
Federation,
assisted
reproductive
technologies
(ART)
have
proven
to
be
one
most
effective
treatments
for
this
condition.
Notably,
introduction
ART
methods,
particularly
vitro
fertilization
(IVF),
has
led
markedly
increased
birth
rates
over
past
two
decades.
Studies
show
that
machine
learning
algorithms
can
process
images
embryos
assess
their
quality,
thus
facilitating
selection
viable
among
them
transfer.
There
are
ethical
and
technical
barriers
hindering
widespread
adoption
artificial
intelligence
(AI)
clinical
practice,
including
concerns
data
privacy
as
well
a
need
train
specialists
deal
with
new
technologies.
AI
analyze
vast
amounts
data,
medical
histories
research
results,
more
accurately
predict
pregnancy
outcomes.
This
enables
doctors
make
justified
decisions.
In
future,
will
able
patient
efficiently,
helping
identify
causes
at
earlier
stages.
Язык: Английский
A review of artificial intelligence applications in in vitro fertilization
Journal of Assisted Reproduction and Genetics,
Год журнала:
2024,
Номер
42(1), С. 3 - 14
Опубликована: Окт. 14, 2024
Язык: Английский
Artificial intelligence as a door opener for a new era of human reproduction
Human Reproduction Open,
Год журнала:
2023,
Номер
2023(4)
Опубликована: Янв. 1, 2023
Язык: Английский
Regeneration and anti-inflammatory effects of stem cells and their extracellular vesicles in gynecological diseases
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
168, С. 115739 - 115739
Опубликована: Окт. 18, 2023
There
are
many
gynecological
diseases,
among
which
breast
cancer
(BC),
cervical
(CC),
endometriosis
(EMs),
and
polycystic
ovary
syndrome
(PCOS)
common
difficult
to
cure.
Stem
cells
(SCs)
a
focus
of
regenerative
medicine.
They
commonly
used
treat
organ
damage
diseases
because
their
potential
for
self-renewal
multidirectional
differentiation.
SCs
also
difficult-to-treat
strong
directional
differentiation
ability
with
unlimited
possibilities,
tendency
adhere
the
diseased
tissue
site,
use
as
carriers
drug
delivery.
can
produce
exosomes
in
paracrine
manner.
Exosomes
be
produced
large
quantities
have
advantage
easy
storage.
Their
safety
efficacy
superior
those
SCs,
considerable
treatment,
such
inhibiting
endometrial
senescence,
promoting
vascular
reconstruction,
improving
anti-inflammatory
immune
functions.
In
this
paper,
we
review
mechanisms
capacity
incurable
current
progress
application
genetic
engineering
provide
foundation
further
research.
Язык: Английский
Chromosome Transplantation: Opportunities and Limitations
Опубликована: Март 15, 2024
There
are
thousands
of
rare
genetic
diseases
that
could
be
treated
with
classical
gene
therapy
strategies
such
as
the
addition
defective
via
viral
or
non-viral
delivery
by
direct
editing.
However,
several
defects
too
complex
for
these
approaches.
These
“genomic
mutations”
include
aneuploidies,
intra
and
inter
chromosomal
rearrangements,
large
deletions,
inversion
copy
number
variations.
Chromosome
Transplantation
(CT)
refers
to
precise
substitution
an
endogenous
chromosome
exogenous
one.
By
concomitant
elimination
one,
every
defect,
irrespective
its
nature,
resolved.
In
current
review,
we
analyze
state
art
this
technique
discuss
possible
application
human
pathology.
CT
might
not
limited
treatment
diseases.
working
on
sex
chromosomes,
showed
female
cells
can
obtained
from
male
cells,
since
chromosome-transplanted
lose
either
chromosome,
giving
rise
46,XY
46,XX
diploid
a
modification
exploited
obtain
gametes
cells.
Moreover,
used
in
veterinary
biology,
entire
chromosomes
containing
advantageous
locus
transferred
animals
zootechnical
interest
without
altering
their
specific
background
need
long
interbreeding.
also
useful
rescue
extinct
species
if
only
were
available.
Finally,
generation
“synthetic”
achieved
repeated
into
recipient
cell.
is
additional
tool
mammalian
Язык: Английский
Chromosome Transplantation: Opportunities and Limitations
Cells,
Год журнала:
2024,
Номер
13(8), С. 666 - 666
Опубликована: Апрель 11, 2024
There
are
thousands
of
rare
genetic
diseases
that
could
be
treated
with
classical
gene
therapy
strategies
such
as
the
addition
defective
via
viral
or
non-viral
delivery
by
direct
editing.
However,
several
defects
too
complex
for
these
approaches.
These
"genomic
mutations"
include
aneuploidies,
intra
and
inter
chromosomal
rearrangements,
large
deletions,
inversion
copy
number
variations.
Chromosome
transplantation
(CT)
refers
to
precise
substitution
an
endogenous
chromosome
exogenous
one.
By
concomitant
elimination
one,
every
defect,
irrespective
its
nature,
resolved.
In
current
review,
we
analyze
state
art
this
technique
discuss
possible
application
human
pathology.
CT
might
not
limited
treatment
diseases.
working
on
sex
chromosomes,
showed
female
cells
can
obtained
from
male
cells,
since
chromosome-transplanted
lose
either
chromosome,
giving
rise
46,XY
46,XX
diploid
a
modification
exploited
obtain
gametes
cells.
Moreover,
used
in
veterinary
biology,
entire
chromosomes
containing
advantageous
locus
transferred
animals
zootechnical
interest
without
altering
their
specific
background
need
long
interbreeding.
also
useful
rescue
extinct
species
if
only
were
available.
Finally,
generation
"synthetic"
achieved
repeated
into
recipient
cell.
is
additional
tool
mammalian
Язык: Английский
Embryo selection, AI and reproductive choice
AI and Ethics,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
Abstract
In
reproductive
medicine,
current
research
into
the
use
of
artificial
intelligence
(AI)
to
improve
embryo
selection
has
been
met
with
enthusiasm.
Within
ethics,
previous
assessments
AI-assisted
have
focused,
for
example,
on
liability
gaps
or
risks
arising
from
opaque
decision-making.
I
argue
that
this
focus
ethical
issues
raised
by
AI
in
alone
is
incomplete
because
it
neglects
how
AI’s
convergence
other
innovative
technologies
raises
further
issues.
describe
acting
as
a
catalyst
social
disruption
human
reproduction
and
profound
change
morality.
The
result
improved
culture,
optimization
through
possibility
selecting
screened
embryo.
This
technological
interplay
creates
pull
towards
assisted
reproduction,
even
those
prospective
parents
who
can
reproduce
without
medical
assistance.
discussing
fictional
case
parents,
linked
moral
disruption.
manifests
itself
deep
uncertainty
about
legitimate
ways
procreating.
explain
rooted
technology-induced
concept
choice.
then
outline
debate
should
be
reframed
light
Язык: Английский