Journal of Aerosol Science, Год журнала: 2024, Номер 181, С. 106419 - 106419
Опубликована: Июнь 12, 2024
Язык: Английский
ChemistrySelect, Год журнала: 2024, Номер 9(23)
Опубликована: Июнь 18, 2024
Abstract Recently, mesoporous silica nanoparticles (MSNs) have emerged as promising candidates in the field of hemorrhage control owing to their extended pore size, high surface area, and excellent biocompatibility. These characteristics directly influence toxicity cells, loading therapeutic agents, release active ions during hemostasis process. Therefore, understanding fundamentals tuning these is important design types carriers. While several literature reviews explored role MSNs control, comprehensive studies focusing on general specific applications remain scarce. This review concentrates principles synthesizing silica, MSNs, techniques for drugs methods onto site injury, kinetics models, biocompatibility, toxicity, unique properties MSNs. Furthermore, article examines mechanism action nanomaterial hemostatic agents.
Язык: Английский
Процитировано
32
Journal of Water Process Engineering, Год журнала: 2023, Номер 57, С. 104695 - 104695
Опубликована: Дек. 29, 2023
Язык: Английский
Процитировано
22
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 230, С. 123175 - 123175
Опубликована: Янв. 6, 2023
Язык: Английский
Процитировано
21
Vaccines, Год журнала: 2025, Номер 13(2), С. 126 - 126
Опубликована: Янв. 27, 2025
Infectious diseases continue to pose a significant global health threat. To combat these challenges, innovative vaccine technologies are urgently needed. Nanoparticles (NPs) have unique properties and emerged as promising platform for developing next-generation vaccines. revolutionizing the field of development, offering new era immunization. They allow creation more effective, stable, easily deliverable Various types NPs, including lipid, polymeric, metal, virus-like particles, can be employed encapsulate deliver components, such mRNA or protein antigens. These NPs protect antigens from degradation, target them specific immune cells, enhance antigen presentation, leading robust durable responses. Additionally, simultaneously multiple antigens, adjuvants, in single formulation, simplifying production administration. Nanovaccines offer approach food- water-borne bacterial diseases, surpassing traditional formulations. Further research is needed address burden infections. This review highlights potential revolutionize platforms. We explore their mechanisms action, current applications, emerging trends. The discusses limitations nanovaccines, solutions role artificial intelligence effective accessible nanovaccines infectious diseases.
Язык: Английский
Процитировано
1
Journal of Hydrology, Год журнала: 2025, Номер unknown, С. 133154 - 133154
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
Bioengineering, Год журнала: 2023, Номер 10(6), С. 672 - 672
Опубликована: Июнь 1, 2023
Bioactive glass (BG) and its polymer composites have demonstrated great potential as scaffolds for bone defect healing. Nonetheless, processing these materials into complex geometry to achieve either anatomy-fitting designs or the desired degradation behavior remains challenging. Additive manufacturing (AM) enables fabrication of BG BG/polymer objects with well-defined shapes intricate porous structures. This work reviewed recent advancements made in AM composite intended tissue engineering. A literature search was performed using Scopus database include publications relevant this topic. The properties based on different inorganic formers, well composites, are first introduced. Melt extrusion, direct ink writing, powder bed fusion, vat photopolymerization technologies that compatible were terms their advances. value lies ability produce patient-specific on-demand spatial distribution biomaterials, both contributing effective healing, by vivo studies. Based relationships among structure, physiochemical properties, biological function, AM-fabricated valuable achieving safer more efficient healing future.
Язык: Английский
Процитировано
15
Toxicology, Год журнала: 2024, Номер 504, С. 153781 - 153781
Опубликована: Март 15, 2024
Язык: Английский
Процитировано
6
ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(5), С. 2636 - 2658
Опубликована: Апрель 12, 2024
Nanosized mesoporous silica has emerged as a promising flexible platform delivering siRNA for cancer treatment. This ordered nanosized provides attractive features of well-defined and tunable porosity, structure, high payload, multiple functionalizations targeted delivery increasing biocompatibility over other polymeric nanocarriers. Moreover, it also overcomes the lacunae associated with traditional administration drugs. Chemically modified porous matrix efficiently entraps molecules prevents their enzymatic degradation premature release. Review discusses synthesis using sol-gel approach advantages different mesostructure. Herein, factors affecting at nanometer scale, shape, porosity nanoparticle surface modification are highlighted to attain desired nanostructured carriers. Additional emphasis is given chemically siRNA, where was chemical moieties such amine (3-aminoropyl) triethoxysilane, polyethylenimine, chitosan, poly(ethylene glycol), cyclodextrin polymer therapeutic loading, improved dispersibility biocompatibility. Upon systemic administration, encounters blood cells, immune organs mainly reticuloendothelial system (RES). Thereby, biodistribution based nanocarriers deliberated design principles smart efficacious silica-siRNA carriers clinical trial status. further reports future scopes challenges developing nanomaterial vehicle demanding FDA approval.
Язык: Английский
Процитировано
5
Nanotoxicology, Год журнала: 2022, Номер 16(6-8), С. 713 - 732
Опубликована: Сен. 14, 2022
The adverse effects of amorphous silica nanoparticles (SiNPs) exposure on the respiratory system were increasingly recognized, however, its potential pathogenesis still remains not fully elucidated. So, this study aimed to explore pulmonary injury, and investigate related mechanisms. Histological investigations illustrated SiNPs triggered lung mainly manifested as alveolar structure destruction, collagen deposition, mitochondrial ultrastructural injury. In particular, greatly enhanced ROS TUNEL positive rate in lungs, both which positively correlated with impairments. Further, underlying mechanisms investigated cultured human bronchial epithelial cells (16HBE). Consistent vivo findings, caused impairments structure, well activation generation oxidative Upon stimuli, respiration was inhibited, while Ca2+ overload cytosol mitochondria owing ER calcium release noticed, resulting mitochondrial-dependent apoptosis. More importantly, dynamics imbalanced toward a fission type, evidenced by upregulated DRP1 phosphorylation at Ser616 (DRP1s616), downregulated DRP1s637, also MFN1, MFN2. Mechanistic revealed that ROS/Ca2+ signaling promoted DRP1-mediated SiNPs, forming vicious cycle, ultimately contributing apoptosis 16HBE. summary, our results disclosed injury through induction via ROS/Ca2+/DRP1-mediated axis.
Язык: Английский
Процитировано
18
Journal of Cleaner Production, Год журнала: 2023, Номер 413, С. 137476 - 137476
Опубликована: Май 11, 2023
Язык: Английский
Процитировано
10