Plants,
Journal Year:
2024,
Volume and Issue:
13(14), P. 1936 - 1936
Published: July 14, 2024
Our
previous
studies
have
shown
physiological
and
yield
intensification
of
selected
crops
with
the
application
nanoparticles
(NPs).
However,
impact
on
quantitative,
qualitative,
parameters
maize
(Zea
mays
L.)
in
field
conditions
remains
highly
debated.
This
study
aimed
to
evaluate
effects
zinc
oxide
(ZnO-NPs),
gold
NPs
anchored
meso-biosilica
(Au-NP-bioSi),
titanium
dioxide
(TiO2-NPs)
as
biological
stimulants
under
during
vegetation
season
2021
Central
European
region.
The
assessed
number
plants,
yield,
components,
nutritional
quality,
including
mineral
nutrients,
starch,
crude
protein
levels.
potential
translocation
these
chemically–physically
stable
NPs,
which
could
pose
a
hazard,
was
also
investigated.
results
indicate
that
Au-NP-bioSi
ZnO-NPs-treatments
were
most
beneficial
for
components
at
statistically
significant
level.
Mineral
nutrient
outcomes
varied,
NP-free
variant
performing
best
phosphorus-levels,
while
ZnO-NPs
optimal
protein.
Starch
content
comparable
across
TiO2-NPs,
Au-NP-bioSi,
control
variants.
Importantly,
we
observed
no
hazardous
or
negative
impacts
grain
quality.
supports
hypothesis
can
serve
an
effective
tool
precise
sustainable
agriculture.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(23)
Published: June 18, 2024
Abstract
Recently,
mesoporous
silica
nanoparticles
(MSNs)
have
emerged
as
promising
candidates
in
the
field
of
hemorrhage
control
owing
to
their
extended
pore
size,
high
surface
area,
and
excellent
biocompatibility.
These
characteristics
directly
influence
toxicity
cells,
loading
therapeutic
agents,
release
active
ions
during
hemostasis
process.
Therefore,
understanding
fundamentals
tuning
these
is
important
design
types
carriers.
While
several
literature
reviews
explored
role
MSNs
control,
comprehensive
studies
focusing
on
general
specific
applications
remain
scarce.
This
review
concentrates
principles
synthesizing
silica,
MSNs,
techniques
for
drugs
methods
onto
site
injury,
kinetics
models,
biocompatibility,
toxicity,
unique
properties
MSNs.
Furthermore,
article
examines
mechanism
action
nanomaterial
hemostatic
agents.
Bioengineering,
Journal Year:
2023,
Volume and Issue:
10(6), P. 672 - 672
Published: June 1, 2023
Bioactive
glass
(BG)
and
its
polymer
composites
have
demonstrated
great
potential
as
scaffolds
for
bone
defect
healing.
Nonetheless,
processing
these
materials
into
complex
geometry
to
achieve
either
anatomy-fitting
designs
or
the
desired
degradation
behavior
remains
challenging.
Additive
manufacturing
(AM)
enables
fabrication
of
BG
BG/polymer
objects
with
well-defined
shapes
intricate
porous
structures.
This
work
reviewed
recent
advancements
made
in
AM
composite
intended
tissue
engineering.
A
literature
search
was
performed
using
Scopus
database
include
publications
relevant
this
topic.
The
properties
based
on
different
inorganic
formers,
well
composites,
are
first
introduced.
Melt
extrusion,
direct
ink
writing,
powder
bed
fusion,
vat
photopolymerization
technologies
that
compatible
were
terms
their
advances.
value
lies
ability
produce
patient-specific
on-demand
spatial
distribution
biomaterials,
both
contributing
effective
healing,
by
vivo
studies.
Based
relationships
among
structure,
physiochemical
properties,
biological
function,
AM-fabricated
valuable
achieving
safer
more
efficient
healing
future.
ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
10(5), P. 2636 - 2658
Published: April 12, 2024
Nanosized
mesoporous
silica
has
emerged
as
a
promising
flexible
platform
delivering
siRNA
for
cancer
treatment.
This
ordered
nanosized
provides
attractive
features
of
well-defined
and
tunable
porosity,
structure,
high
payload,
multiple
functionalizations
targeted
delivery
increasing
biocompatibility
over
other
polymeric
nanocarriers.
Moreover,
it
also
overcomes
the
lacunae
associated
with
traditional
administration
drugs.
Chemically
modified
porous
matrix
efficiently
entraps
molecules
prevents
their
enzymatic
degradation
premature
release.
Review
discusses
synthesis
using
sol-gel
approach
advantages
different
mesostructure.
Herein,
factors
affecting
at
nanometer
scale,
shape,
porosity
nanoparticle
surface
modification
are
highlighted
to
attain
desired
nanostructured
carriers.
Additional
emphasis
is
given
chemically
siRNA,
where
was
chemical
moieties
such
amine
(3-aminoropyl)
triethoxysilane,
polyethylenimine,
chitosan,
poly(ethylene
glycol),
cyclodextrin
polymer
therapeutic
loading,
improved
dispersibility
biocompatibility.
Upon
systemic
administration,
encounters
blood
cells,
immune
organs
mainly
reticuloendothelial
system
(RES).
Thereby,
biodistribution
based
nanocarriers
deliberated
design
principles
smart
efficacious
silica-siRNA
carriers
clinical
trial
status.
further
reports
future
scopes
challenges
developing
nanomaterial
vehicle
demanding
FDA
approval.
Nanotoxicology,
Journal Year:
2022,
Volume and Issue:
16(6-8), P. 713 - 732
Published: Sept. 14, 2022
The
adverse
effects
of
amorphous
silica
nanoparticles
(SiNPs)
exposure
on
the
respiratory
system
were
increasingly
recognized,
however,
its
potential
pathogenesis
still
remains
not
fully
elucidated.
So,
this
study
aimed
to
explore
pulmonary
injury,
and
investigate
related
mechanisms.
Histological
investigations
illustrated
SiNPs
triggered
lung
mainly
manifested
as
alveolar
structure
destruction,
collagen
deposition,
mitochondrial
ultrastructural
injury.
In
particular,
greatly
enhanced
ROS
TUNEL
positive
rate
in
lungs,
both
which
positively
correlated
with
impairments.
Further,
underlying
mechanisms
investigated
cultured
human
bronchial
epithelial
cells
(16HBE).
Consistent
vivo
findings,
caused
impairments
structure,
well
activation
generation
oxidative
Upon
stimuli,
respiration
was
inhibited,
while
Ca2+
overload
cytosol
mitochondria
owing
ER
calcium
release
noticed,
resulting
mitochondrial-dependent
apoptosis.
More
importantly,
dynamics
imbalanced
toward
a
fission
type,
evidenced
by
upregulated
DRP1
phosphorylation
at
Ser616
(DRP1s616),
downregulated
DRP1s637,
also
MFN1,
MFN2.
Mechanistic
revealed
that
ROS/Ca2+
signaling
promoted
DRP1-mediated
SiNPs,
forming
vicious
cycle,
ultimately
contributing
apoptosis
16HBE.
summary,
our
results
disclosed
injury
through
induction
via
ROS/Ca2+/DRP1-mediated
axis.
Vaccines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 126 - 126
Published: Jan. 27, 2025
Infectious
diseases
continue
to
pose
a
significant
global
health
threat.
To
combat
these
challenges,
innovative
vaccine
technologies
are
urgently
needed.
Nanoparticles
(NPs)
have
unique
properties
and
emerged
as
promising
platform
for
developing
next-generation
vaccines.
revolutionizing
the
field
of
development,
offering
new
era
immunization.
They
allow
creation
more
effective,
stable,
easily
deliverable
Various
types
NPs,
including
lipid,
polymeric,
metal,
virus-like
particles,
can
be
employed
encapsulate
deliver
components,
such
mRNA
or
protein
antigens.
These
NPs
protect
antigens
from
degradation,
target
them
specific
immune
cells,
enhance
antigen
presentation,
leading
robust
durable
responses.
Additionally,
simultaneously
multiple
antigens,
adjuvants,
in
single
formulation,
simplifying
production
administration.
Nanovaccines
offer
approach
food-
water-borne
bacterial
diseases,
surpassing
traditional
formulations.
Further
research
is
needed
address
burden
infections.
This
review
highlights
potential
revolutionize
platforms.
We
explore
their
mechanisms
action,
current
applications,
emerging
trends.
The
discusses
limitations
nanovaccines,
solutions
role
artificial
intelligence
effective
accessible
nanovaccines
infectious
diseases.