The Science of The Total Environment,
Год журнала:
2023,
Номер
886, С. 163991 - 163991
Опубликована: Май 9, 2023
Endocrine
disrupting
chemicals
(EDCs)
can
interfere
with
hormonal
actions
and
have
been
associated
a
higher
incidence
of
metabolic
disorders.
They
affect
numerous
physiological,
biochemical,
endocrinal
activities,
including
reproduction,
metabolism,
immunity,
behavior.
The
purpose
this
review
was
to
elucidate
the
association
EDCs
in
food
gut
microbiota
EDC
exposure
induces
changes
that
lead
microbial
dysbiosis.
Products
by-products
released
by
metabolism
be
taken
up
host.
Changes
composition
production
metabolites
may
major
impact
on
host
metabolism.
Journal of Agricultural and Food Chemistry,
Год журнала:
2020,
Номер
68(47), С. 13916 - 13928
Опубликована: Ноя. 5, 2020
Perfluorooctanoic
acid
(PFOA)
is
an
eight-carbon
perfluoroalkyl
chemical
and
has
been
detected
widely
in
many
media.
Although
the
toxic
effect
of
PFOA
confirmed,
influence
on
gut
brain
not
cleared.
Male
C57BL/6J
mice
were
exposed
to
different
concentrations
(0,
0.5,
1,
3
mg/Kg
(bw)/day
for
35
days
this
work.
The
results
indicate
that
exposure
could
damage
intestinal
barrier
integrity
impair
synaptic
structure.
also
caused
inflammation
by
increasing
lipopolysaccharide,
tumor
necrosis
factor-α,
interleukin-1
beta,
cyclooxygenase-2
decreasing
interleukin-10.
Interestingly,
fecal
microbiota
transplantation
treatment
attenuate
a
series
PFOA-induced
changes
certain
extent.
suggest
potential
deleterious
effects
brain,
may
play
essential
role
evaluating
induced
exposure.
Ecotoxicology and Environmental Safety,
Год журнала:
2022,
Номер
241, С. 113732 - 113732
Опубликована: Июнь 6, 2022
The
indiscriminate
use
of
deltamethrin
in
agriculture
and
aquaculture
can
lead
to
residues
increased
many
regions,
which
poses
negative
impacts
on
intestinal
health
aquatic
organisms.
Although
the
potential
toxicity
have
recently
attracted
attention,
comprehensive
studies
injuries
after
chronic
exposure
remain
poorly
understood.
Herein,
a
28-day
test,
crucian
carp
expose
different
concentrations
(0,
0.3,
0.6
μg/L)
were
used
as
research
object.
We
found
that
morphology
changes
goblet
cells
tissue,
extent
tissue
injury
along
with
increasing
dose
deltamethrin.
Additionally,
genes
expression
antioxidant
activity
(Cu/Zn
superoxide
dismutase
(Cu-Zn
SOD),
glutathione
peroxidase
1
(GPX1),
catalase
(CAT)),
inflammatory
response
(tumor
necrosis
factor
alpha
(TNFα),
interferon
gamma
(IFNγ),
interleukin
beta
(IL-1β)),
tight
junctions
(Claudin
12
(CLDN12),
junction
protein
(ZO-1))
dramatically
increased.
Meanwhile,
apoptosis
autophagy
process
triggered
through
caspase-9
cascade
related
5
(ATG5)-
(ATG12)
conjugate.
Besides,
amount
Proteobacteria
Verrucomicrobiota,
while
decreased
Fusobacteriota
abundance,
resulting
microbiota
function
disorders.
In
summary,
our
results
highlight
cause
serious
physiological
flora
disturbances.
Toxics,
Год журнала:
2023,
Номер
11(3), С. 281 - 281
Опубликована: Март 19, 2023
Alterations
of
the
normal
gut
microbiota
can
cause
various
human
health
concerns.
Environmental
chemicals
are
one
drivers
such
disturbances.
The
aim
our
study
was
to
examine
effects
exposure
perfluoroalkyl
and
polyfluoroalkyl
substances
(PFAS)-specifically,
perfluorooctane
sulfonate
(PFOS)
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)
propanoic
acid
(GenX)-on
microbiome
small
intestine
colon,
as
well
on
liver
metabolism.
Male
CD-1
mice
were
exposed
PFOS
GenX
in
different
concentrations
compared
controls.
found
have
bacterial
community
both
colon
based
16S
rRNA
profiles.
High
doses
predominantly
led
increases
abundance
Clostridium
sensu
stricto,
Alistipes,
Ruminococcus,
while
generally
altered
Lactobacillus,
Limosilactobacillus,
Parabacteroides,
Staphylococcus,
Ligilactobacillus.
These
treatments
associated
with
alterations
several
important
microbial
metabolic
pathways
colon.
Untargeted
LC-MS/MS
metabolomic
analysis
liver,
intestine,
yielded
a
set
compounds
significantly
by
GenX.
In
these
metabolites
host
implicated
synthesis
lipids,
steroidogenesis,
metabolism
amino
acids,
nitrogen,
bile
acids.
Collectively,
results
suggest
that
major
perturbations
gastrointestinal
tract,
aggravating
toxicity,
hepatotoxicity,
disorders.
The Science of The Total Environment,
Год журнала:
2023,
Номер
886, С. 163991 - 163991
Опубликована: Май 9, 2023
Endocrine
disrupting
chemicals
(EDCs)
can
interfere
with
hormonal
actions
and
have
been
associated
a
higher
incidence
of
metabolic
disorders.
They
affect
numerous
physiological,
biochemical,
endocrinal
activities,
including
reproduction,
metabolism,
immunity,
behavior.
The
purpose
this
review
was
to
elucidate
the
association
EDCs
in
food
gut
microbiota
EDC
exposure
induces
changes
that
lead
microbial
dysbiosis.
Products
by-products
released
by
metabolism
be
taken
up
host.
Changes
composition
production
metabolites
may
major
impact
on
host
metabolism.
