The connection between autophagy and ferroptosis in AKI: recent advances regarding selective autophagy DOI Creative Commons
Chunyu Pan,

Hairui Zhao,

Xiaojing Cai

и другие.

Renal Failure, Год журнала: 2024, Номер 46(2)

Опубликована: Авг. 4, 2024

Acute kidney injury (AKI) is a significant issue in public health, displaying high occurrence rate and mortality rate. Ferroptosis, form of programmed cell death (PCD), characterized by iron accumulation intensified lipid peroxidation. Recent studies have demonstrated the pivotal significance ferroptosis AKI caused diverse stimuli, including ischemia-reperfusion (IRI), sepsis toxins. Autophagy, multistep process that targets damaged organelles macromolecules for degradation recycling, also plays an essential role AKI. Previous research has autophagy deletion proximal tubules could aggravate tubular renal function loss, indicating protective Consequently, finding ways to stimulate become crucial therapeutic strategy. The recent discovery selective influencing identified new highlighted importance understanding cross-talk between ferroptosis. This study aims provide overview signaling pathways involved autophagy, focusing on mechanisms functions autophagy-dependent We hope establish foundation future investigations into interaction as well other diseases.

Язык: Английский

Treatment of liver fibrosis: Past, current, and future DOI Open Access
Chunye Zhang, Shuai Liu, Ming Yang

и другие.

World Journal of Hepatology, Год журнала: 2023, Номер 15(6), С. 755 - 774

Опубликована: Июнь 25, 2023

Liver fibrosis accompanies the progression of chronic liver diseases independent etiologies, such as hepatitis viral infection, alcohol consumption, and metabolic-associated fatty disease. It is commonly associated with injury, inflammation, cell death. characterized by abnormal accumulation extracellular matrix components that are expressed myofibroblasts collagens alpha-smooth actin proteins. Activated hepatic stellate cells contribute to major population myofibroblasts. Many treatments for have been investigated in clinical trials, including dietary supplementation (e.g., vitamin C), biological treatment simtuzumab), drug pegbelfermin natural herbs), genetic regulation non-coding RNAs), transplantation stem hematopoietic cells). However, none these has approved Food Drug Administration. The efficacy can be evaluated histological staining methods, imaging serum biomarkers, well scoring systems, fibrosis-4 index, aspartate aminotransferase platelet ratio, non-alcoholic disease score. Furthermore, reverse slowly frequently impossible advanced or cirrhosis. To avoid life-threatening stage fibrosis, anti-fibrotic treatments, especially combined behavior prevention, treatment, drugs herb medicines, needed. This review summarizes past studies current future fibrosis.

Язык: Английский

Процитировано

45
Iron, Oxidative Stress, and Metabolic Dysfunction—Associated Steatotic Liver Disease DOI Creative Commons

Sophie Gensluckner,

Bernhard Wernly, Christian Datz

и другие.

Antioxidants, Год журнала: 2024, Номер 13(2), С. 208 - 208

Опубликована: Фев. 7, 2024

Excess free iron is a substrate for the formation of reactive oxygen species (ROS), thereby augmenting oxidative stress. Oxidative stress well-established cause organ damage in liver, main site storage. Ferroptosis, an iron-dependent mechanism regulated cell death, has recently been gaining attention development and progression liver disease. We therefore summarize mechanisms metabolism, its close connection to ferroptosis, particular relevance disease metabolic-dysfunction-associated fatty potential targets therapy from clinical perspective.

Язык: Английский

Процитировано

25
Natural products modulating MAPK for CRC treatment: a promising strategy DOI Creative Commons
Lin Zhou, Jinlong Zhang, Kangning Zhao

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 5, 2025

Colorectal cancer (CRC) is a common malignant tumor of the digestive system, and pathogenic mechanism still unclear, mostly related to genetics, immunity, inflammation, abnormal activation tumor-related signaling pathways. MAPK belongs Ser/Thr kinase family, which plays an important role in complex cellular programs such as regulation cell proliferation, differentiation, apoptosis, angiogenesis, metastasis. Increasing evidence supports that highly correlated with risk CRC. Targeting may be therapeutic strategy, natural products show great potential regulating MAPK-related proteins. In this paper, we searched PubMed, Web Science CNKI databases keywords "colorectal cancer, products, pathway, ERK, P38, JNK" for relevant studies last 14 years from 2010 2024. This work retrieved 47 studies, aiming provide new strategies CRC patients lay foundation drug development.

Язык: Английский

Процитировано

3
Curcumin and Ferroptosis: a Promising Target for Disease Prevention and Treatment DOI
Zahra Foroutan, Alexandra E. Butler, Gökhan Zengin

и другие.

Cell Biochemistry and Biophysics, Год журнала: 2024, Номер 82(2), С. 343 - 349

Опубликована: Янв. 6, 2024

Язык: Английский

Процитировано

11
Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches DOI Creative Commons

YiLin Luo,

Xin Yue Bai,

L.J. Zhang

и другие.

Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 2485 - 2529

Опубликована: Июнь 1, 2024

Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,

Язык: Английский

Процитировано

11
Curcumol: a review of its pharmacology, pharmacokinetics, drug delivery systems, structure–activity relationships, and potential applications DOI

Sicheng Zhai,

Rui Wang, Jingyuan Wang

и другие.

Inflammopharmacology, Год журнала: 2024, Номер 32(3), С. 1659 - 1704

Опубликована: Март 23, 2024

Язык: Английский

Процитировано

10
Research Progress on Sesquiterpenoids of Curcumae Rhizoma and Their Pharmacological Effects DOI Creative Commons
Ting Cui, Boyu Li, Fei Liu

и другие.

Biomolecules, Год журнала: 2024, Номер 14(4), С. 387 - 387

Опубликована: Март 23, 2024

Curcumae Rhizoma, a traditional Chinese medicine with wide range of pharmacological activities, is obtained from the dried rhizomes Curcuma phaeocaulis VaL., kwangsiensis S. G. Lee et C. F. Liang, and wenyujin Y. H. Chen Ling. Sesquiterpenoids curcuminoids are found to be main constituents Rhizoma. composed three isoprene units susceptible complex transformations, such as cyclization, rearrangement, oxidation. They most structurally diverse class plant-based natural products biological activities widely in nature. In recent years, scholars have conducted abundant studies on structures properties components This article elucidates chemical structures, medicinal properties, sesquiterpenoids (a total 274 compounds) isolated We summarized extraction isolation methods for sesquiterpenoids, established component library analyzed structural variances among sourced Rhizoma botanical origins. Furthermore, our investigation reveals array sesquiterpenoid types, encompassing guaiane-type, germacrane-type, eudesmane-type, elemane-type, cadinane-type, carane-type, bisabolane-type, humulane-type, other emphasizing relationship between diversity activity. hope provide valuable reference further research exploitation pave way development new drugs derived plants.

Язык: Английский

Процитировано

7
Ferroptosis in organ fibrosis: Mechanisms and therapeutic approaches DOI

Zhi-Hong Ning,

Xiuheng Wang, Yue Zhao

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 151, С. 114341 - 114341

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1
Pharmacological modulation of ferroptosis as a therapeutic target for liver fibrosis DOI Creative Commons

Le Li,

Zhijun Zhu

Frontiers in Pharmacology, Год журнала: 2023, Номер 13

Опубликована: Янв. 10, 2023

Liver fibrosis, which is characterized by the excessive deposition of extracellular matrix (ECM) materials (primarily fibrillar collagen-I), an abnormal repair reaction and pathological outcome chronic liver diseases caused alcohol abuse, non-alcoholic fatty disease, hepatitis B C virus infections. fibrosis often progresses to cirrhosis hepatocellular carcinoma. Ferroptosis, lipid peroxidation, a form iron-dependent non-apoptotic cell death, recent studies have reported that ferroptosis contribute development fibrosis. Moreover, several agents demonstrated therapeutic effects in experimental models inducing hepatic stellate (HSCs) ferroptosis. This review delineates specific mechanism contributes Specifically, we focused on different types can induce HSCs summarize their pharmacological effectiveness for treatment. We suggest may be potential useful target novel therapies preventing treating

Язык: Английский

Процитировано

15
Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis DOI Creative Commons
Sen Li,

Qian-Jun Ren,

Can-Hao Xie

и другие.

World Journal of Gastroenterology, Год журнала: 2024, Номер 30(15), С. 2143 - 2154

Опубликована: Апрель 19, 2024

BACKGROUND Liver fibrosis is a compensatory response during the tissue repair process in chronic liver injury, and finally leads to cirrhosis or even hepatocellular carcinoma. The pathogenesis of hepatic associated with progressive accumulation activated stellate cells (HSCs), which can transdifferentiate into myofibroblasts produce an excess extracellular matrix (ECM). Myofibroblasts are main source excessive ECM responsible for fibrosis. Therefore, (aHSCs), principal producing injured liver, promising therapeutic target treatment AIM To explore effect taurine on aHSC proliferation mechanisms involved. METHODS Human HSCs (LX-2) were randomly divided five groups: Normal control group, platelet-derived growth factor-BB (PDGF-BB) (20 ng/mL) treated low, medium, high dosage (10 mmol/L, 50 100 respectively) PDGF-BB group. Cell Counting Kit-8 method was performed evaluate viability aHSCs. Enzyme-linked immunosorbent assay used estimate levels reactive oxygen species (ROS), malondialdehyde, glutathione, iron concentration. Transmission electron microscopy applied observe autophagosomes ferroptosis features Quantitative real-time polymerase chain reaction Western blot analysis detect expression α-SMA, Collagen I, Fibronectin 1, LC3B, ATG5, Beclin PTGS2, SLC7A11, p62. RESULTS Taurine promoted death aHSCs reduced deposition ECM. Treatment could alleviate autophagy inhibit their activation, by decreasing autophagosome formation, downregulating LC3B 1 protein expression, upregulating p62 expression. Meanwhile, triggered ferritinophagy eliminate characterized overload, lipid ROS accumulation, glutathione depletion, peroxidation. Furthermore, bioinformatics demonstrated that had direct targeting nuclear receptor coactivator 4, exhibiting best average binding affinity -20.99 kcal/mol. CONCLUSION exerts effects via involve inhibition trigger

Язык: Английский

Процитировано

6