Ferroptosis: mechanisms and therapeutic targets
MedComm,
Год журнала:
2024,
Номер
5(12)
Опубликована: Ноя. 20, 2024
Ferroptosis
is
a
nonapoptotic
form
of
cell
death
characterized
by
iron-dependent
lipid
peroxidation
in
membrane
phospholipids.
Since
its
identification
2012,
extensive
research
has
unveiled
involvement
the
pathophysiology
numerous
diseases,
including
cancers,
neurodegenerative
disorders,
organ
injuries,
infectious
autoimmune
conditions,
metabolic
and
skin
diseases.
Oxidizable
lipids,
overload
iron,
compromised
antioxidant
systems
are
known
as
critical
prerequisites
for
driving
overwhelming
peroxidation,
ultimately
leading
to
plasma
rupture
ferroptotic
death.
However,
precise
regulatory
networks
governing
ferroptosis
ferroptosis-targeted
therapy
these
diseases
remain
largely
undefined,
hindering
development
pharmacological
agonists
antagonists.
In
this
review,
we
first
elucidate
core
mechanisms
summarize
epigenetic
modifications
(e.g.,
histone
modifications,
DNA
methylation,
noncoding
RNAs,
N6-methyladenosine
modification)
nonepigenetic
genetic
mutations,
transcriptional
regulation,
posttranslational
modifications).
We
then
discuss
association
between
disease
pathogenesis
explore
therapeutic
approaches
targeting
ferroptosis.
also
introduce
potential
clinical
monitoring
strategies
Finally,
put
forward
several
unresolved
issues
which
progress
needed
better
understand
hope
review
will
offer
promise
application
therapies
context
human
health
disease.
Язык: Английский
Skin Metabolic Signatures of Psoriasis and Psoriasis Concurrent with Metabolic Syndrome
Journal of Inflammation Research,
Год журнала:
2025,
Номер
Volume 18, С. 505 - 517
Опубликована: Янв. 1, 2025
Purpose:
Psoriasis
is
a
complex
inflammatory
skin
disorder
that
closely
associated
with
metabolic
syndrome
(MetS).
Limited
information
available
on
changes
in
psoriasis;
the
effect
of
concurrent
MetS
psoriatic
metabolite
levels
unknown.
We
aimed
to
expand
this
through
metabolomic
analysis.
Patients
and
Methods:
Untargeted
metabolomics
was
conducted
using
samples
from
38
patients
psoriasis
vulgaris
(PVMS),
23
without
(PVNMS),
10
healthy
controls
(HC).
Data
analyses,
including
multivariate
statistical
analysis,
KEGG
pathway
enrichment
correlation
receiver
operating
characteristic
curve
were
performed.
Results:
Significant
discrepancies
found
between
metabolites
HC
PVNMS
groups,
particularly
those
involved
nucleotide
glycerophospholipid
metabolism.
Fifteen
these
positively
correlated
severity.
Furthermore,
affect
profiles
psoriasis.
There
some
consistent
alterations
both
PVNMS/HC
PVMS/PVNMS
comparisons.
Conclusion:
This
study
may
provide
new
insights
into
link
metabolism
inflammation
mechanism
underlying
interaction
MetS.
Keywords:
psoriasis,
syndrome,
metabolomics,
metabolism,
Язык: Английский
Emerging role of ferroptosis in ultraviolet radiation-driven skin photoaging: a narrative review
Photochemical & Photobiological Sciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Язык: Английский
Targeting regulated cell death: Apoptosis, necroptosis, pyroptosis, ferroptosis, and cuproptosis in anticancer immunity
Journal of Translational Internal Medicine,
Год журнала:
2025,
Номер
13(1), С. 10 - 32
Опубликована: Фев. 1, 2025
In
the
evolving
landscape
of
cancer
treatment,
strategic
manipulation
regulated
cell
death
(RCD)
pathways
has
emerged
as
a
crucial
component
effective
anti-tumor
immunity.
Evidence
suggests
that
tumor
cells
undergoing
RCD
can
modify
immunogenicity
microenvironment
(TME),
potentially
enhancing
its
ability
to
suppress
progression
and
metastasis.
this
review,
we
first
explore
mechanisms
apoptosis,
necroptosis,
pyroptosis,
ferroptosis,
cuproptosis,
along
with
crosstalk
between
these
modalities.
We
then
discuss
how
processes
activate
antigen-presenting
cells,
facilitate
cross-priming
CD8+
T
trigger
immune
responses,
highlighting
complex
effects
novel
forms
on
TME
biology.
Furthermore,
summarize
potential
drugs
nanoparticles
induce
or
inhibit
emerging
their
therapeutic
roles
in
treatment.
Finally,
put
forward
existing
challenges
future
prospects
for
targeting
anti-cancer
Overall,
review
enhances
our
understanding
molecular
biological
impacts
RCD-based
therapies,
providing
new
perspectives
strategies
Язык: Английский
Targeting LINC00707 by vitamin D3 attenuates nitrogen mustard-caused dermal toxicity through inhibiting ferroptosis
Redox Biology,
Год журнала:
2025,
Номер
unknown, С. 103628 - 103628
Опубликована: Апрель 1, 2025
Nitrogen
mustard
(NM)
causes
severe
skin
injury
that
is
lack
of
effective
and
targeted
therapies.
Vitamin
D3
(VD3)
emerges
as
a
promising
treatment
option
for
NM-caused
dermal
toxicity;
however,
the
underlying
mechanisms
are
currently
unclear.
Herein,
we
identified
NM
markedly
promoted
ferroptosis
by
measurement
decreased
cell
viability,
glutathione,
glutathione
peroxidase
4
solute
carrier
family
7
member
11
levels,
increased
ROS,
lipid
iron/Fe2+
malondialdehyde
contents
in
vitro
vivo.
Ferrostin-1
(Fer-1,
inhibitor)
attenuated
death
keratinocytes.
Meanwhile,
significantly
inhibited
phosphorylation
AKT1
glycogen
synthase
kinase
3β
(GSK3β)
nuclear
factor
erythroid
2-related
2
(Nrf2)
translocation,
LINC00707
expression.
Furthermore,
NM-induced
keratinocytes
was
abolished
with
agonists
Nrf2
(tBHQ)
(SC79),
inhibitor
GSK3β
(AR-A014418),
overexpression
or
knockdown.
Mechanistically,
directly
bound
protein
domain
suppressed
its
activated
thereby
inactivating
Nrf2,
subsequently
inducing
NM-treated
Moreover,
VD3
notably
expression,
inactivated
GSK3β,
translocation
cytotoxicity
induced
The
protective
effects
against
toxicity
were
blocked
erastin
(a
inducer),
siRNA,
enhanced
knockdown
Fer-1
In
conclusion,
ameliorated
inhibiting
ferroptosis,
which
partially
mediated
through
LINC00707-AKT1-GSK3β-Nrf2
signaling
pathway.
Язык: Английский
Unveiling ferroptosis: a new frontier in skin disease research
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 4, 2024
Ferroptosis,
a
form
of
regulated
cell
death
distinct
from
apoptosis,
necrosis,
and
autophagy,
is
increasingly
recognized
for
its
role
in
skin
disease
pathology.
Characterized
by
iron
accumulation
lipid
peroxidation,
ferroptosis
has
been
implicated
the
progression
various
conditions,
including
psoriasis,
photosensitive
dermatitis,
melanoma.
This
review
provides
an
in-depth
analysis
molecular
mechanisms
underlying
compares
cellular
effects
with
other
forms
context
health
disease.
We
systematically
examine
five
specific
diseases,
ichthyosis,
polymorphous
light
eruption
(PMLE),
vitiligo,
melanoma,
detailing
influence
on
pathogenesis
progression.
Moreover,
we
explore
current
clinical
landscape
ferroptosis-targeted
therapies,
discussing
their
potential
managing
treating
diseases.
Our
aim
to
shed
therapeutic
modulating
research
practice.
Язык: Английский