Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial

BMJ, Год журнала: 2021, Номер unknown, С. n1448 - n1448

Опубликована: Июнь 30, 2021

Abstract Objective To determine whether dietary interventions that increase n-3 fatty acids with and without reduction in n-6 linoleic acid can alter circulating lipid mediators implicated headache pathogenesis, decrease adults migraine. Design Three arm, parallel group, randomized, modified double blind, controlled trial. Setting Ambulatory, academic medical center the United States over 16 weeks. Participants 182 participants (88% women, mean age 38 years) migraines on 5-20 days per month (67% met criteria for chronic migraine). Interventions diets designed eicosapentaenoic (EPA), docosahexaenoic (DHA), altered as variables: H3 diet (n=61)—increase EPA+DHA to 1.5 g/day maintain at around 7% of energy; H3-L6 ≤1.8% control (n=60)—maintain <150 mg/day energy. All received foods accounting two thirds daily food energy continued usual care. Main outcome measures The primary endpoints (week 16) were antinociceptive mediator 17-hydroxydocosahexaenoic (17-HDHA) blood impact test (HIT-6), a six item questionnaire assessing quality life. Headache frequency was assessed an electronic diary. Results In intention-to-treat analyses (n=182), increased 17-HDHA (log ng/mL) compared (baseline-adjusted difference 0.6, 95% confidence interval 0.2 0.9; 0.7, 0.4 1.1, respectively). observed improvement HIT-6 scores groups not statistically significant (−1.6, −4.2 1.0, −1.5, 1.2, Compared diet, decreased total hours day (−1.7, −2.5 −0.9, −1.3, −2.1 −0.5, respectively), moderate severe (−0.8, −1.2 −0.4, −0.7, −1.1 −0.3, (−4.0, −5.2 −2.7, −2.0, −3.3 more than (−2.0, −3.2 −0.8), suggesting additional benefit from lowering acid. several their nociceptive oxylipin derivatives plasma, serum, erythrocytes or immune cells, but did classic calcitonin gene related peptide prostaglandin E2. Conclusions bioactive pathogenesis severity headaches, significantly improve Trial registration ClinicalTrials.gov NCT02012790

Язык: Английский

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Post-Traumatic Headache: A Review of Prevalence, Clinical Features, Risk Factors, and Treatment Strategies

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(13), С. 4233 - 4233

Опубликована: Июнь 23, 2023

Post-traumatic headache (PTH) is a common and debilitating consequence of mild traumatic brain injury (mTBI) that can occur over one year after the head impact event. Thus, better understanding underlying pathophysiology risk factors could facilitate early identification management PTH. There are several influence reporting PTH prevalence, including definition concussion The main for PTHs include history migraines or headaches, female gender, younger age, greater severity injury, co-occurring psychological symptoms, such as anxiety depression. clinical profiles vary based on onset, duration, severity: tension-type headache, migraine cervicogenic occipital neuralgia, new daily persistent headache. Pharmacological treatments often consist analgesics non-steroidal anti-inflammatory drugs, tricyclic antidepressants, antiepileptic medication. Cognitive behavioral therapy, relaxation techniques, biofeedback, physical therapy also be used treatment. Our work highlighted need more rigorous studies to describe importance identifying patient-centered evaluate effectiveness existing treatment options. Clinicians should consider multidisciplinary approach managing PTH, pharmacotherapy, cognitive lifestyle changes.

Язык: Английский

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Regulatory lipid vicinal diols counteract the biological activity of epoxy fatty acids and can act as biomarkers and mechanisms for disease progression

Pharmacology & Therapeutics, Год журнала: 2023, Номер 248, С. 108454 - 108454

Опубликована: Июнь 1, 2023

Язык: Английский

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Circulating polyunsaturated fatty acids, pressure pain thresholds, and nociplastic pain conditions

Prostaglandins Leukotrienes and Essential Fatty Acids, Год журнала: 2022, Номер 184, С. 102476 - 102476

Опубликована: Июль 23, 2022

Язык: Английский

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Levels of Arachidonic Acid–Derived Oxylipins and Anandamide Are Elevated Among Military APOE ɛ4 Carriers With a History of Mild Traumatic Brain Injury and Post-Traumatic Stress Disorder Symptoms

Neurotrauma Reports, Год журнала: 2023, Номер 4(1), С. 643 - 654

Опубликована: Сен. 1, 2023

Currently approved blood biomarkers detect intracranial lesions in adult patients with mild to moderate traumatic brain injury (TBI) acutely post-injury. However, are still needed help a differential diagnosis of TBI (mTBI) and post-traumatic stress disorder (PTSD) at chronic post-injury time points. Owing the association between phospholipid (PL) dysfunction consequences TBI, we hypothesized that examining bioactive PL metabolites (oxylipins ethanolamides) would identify long-term lipid changes associated mTBI PTSD. Lipid extracts plasma from active-duty soldiers deployed Iraq/Afghanistan wars (control = 52, 21, PTSD 34, + 13) were subjected liquid chromatography/mass spectrometry analysis examine oxylipins ethanolamides. Linear regression analyses followed by post hoc comparisons performed assess these lipids diagnostic classifications. Significant differences found derived arachidonic acid (AA) controls mTBI, PTSD, groups. Levels AA-derived through cytochrome P450 pathways anandamide significantly elevated among who carriers apolipoprotein E E4 allele. These studies demonstrate may be unique Further, AA indicative an underlying inflammatory process warrants further investigation. Future validation larger cohorts required determine potential application this approach providing clinical setting.

Язык: Английский

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Adjunctive dietary intervention for bipolar disorder: a randomized, controlled, parallel‐group, modified double‐blinded trial of a high n‐3 plus low n‐6 diet

Bipolar Disorders, Год журнала: 2021, Номер 24(2), С. 171 - 184

Опубликована: Июль 4, 2021

To investigate the preliminary efficacy of a high n-3 plus low n-6 (H3-L6) dietary intervention in improving mood stability Bipolar Disorder (BD) when compared to with usual U.S. levels and polyunsaturated fatty acid (PUFA) intakes (control diet, CD).This 2-arm, parallel-group, randomized, modified double-blind, controlled 48-week study 12-week intensive diet subjects BD was conducted at single suburban-rural site mid-Atlantic region. Participants DSM-IV TR I or II hypomanic depressive symptoms were stratified on gender (N = 82). The included provision group-specific foods counseling. Variability measured by twice-daily, ecological momentary analysis (EMA) paradigm, group differences analyzed using multilevel models. Circulating acids baseline after 4, 8, 12 weeks exposure.All 82 randomized participants biochemical analyses. Seventy completed least 2 EMA surveys primary mood, energy, irritability, pain as reduced H3-L6 CD group. No significant mean ratings symptoms, any other symptom measures, detected. effect target PUFAs significantly differed over time.A adjunctive care showed variability BD.ClinicalTrials.Gov NCT02272010.

Язык: Английский

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Associations between Plasma Lipid Mediators and Chronic Daily Headache Outcomes in Patients Randomized to a Low Linoleic Acid Diet with or without Added Omega-3 Fatty Acids

Metabolites, Год журнала: 2023, Номер 13(6), С. 690 - 690

Опубликована: Май 25, 2023

A previous report showed that 12-week lowering of dietary omega-6 linoleic acid (LA) coupled with increased omega-3 polyunsaturated fatty (PUFA) intake (H3-L6 diet) reduced headache frequency and improved quality life in patients chronic daily headaches (CDHs) compared to LA reduction alone (L6 diet). The trial also targeted manipulation alters PUFA-derived lipid mediators endocannabinoids. However, several additional classes associated pain preclinical models were not measured. current secondary analysis investigated whether the clinical benefits H3-L6 diet related changes plasma unesterified known be involved nociception, including prostanoids. Lipid measured by ultra-high-pressure liquid chromatography tandem mass-spectrometry. Compared baseline, or without added acids did alter n-6 mediators, although species derived from LA, di-homo-gamma-linolenic acid, arachidonic positively intensity, as well mental health burden. Alpha-linolenic (ALA)-derived metabolites they change baseline either group. docosahexaenoic (DHA)-derived epoxides more elevated group L6 Diet-induced elevations DHA-epoxides frequency, better physical health, (p < 0.05). Prostanoids detected, except for PGF2-alpha, which was any outcomes. This study demonstrates diet-induced headaches, whereas PUFA ALA nociception. mediator associations paralleled management outcomes this population. findings point a network multiple diet-modifiable targets individuals CDHs.

Язык: Английский

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Excessive dietary linoleic acid promotes plasma accumulation of pronociceptive fatty acyl lipid mediators

Scientific Reports, Год журнала: 2022, Номер 12(1)

Опубликована: Окт. 25, 2022

Various fatty acyl lipid mediators are derived from dietary polyunsaturated acids (PUFAs) and modulate nociception. The modern diet is rich in linoleic acid, which associated with nociceptive hypersensitivities may present a risk factor for developing pain conditions. Although recommendations about acid intake exist some diseases (e.g. cardiovascular disease), the role of promoting disorders not completely understood. To determine how content influences accumulation pro- anti-nociceptive mediators, we created novel rodent diets using custom triglyceride blends either or oleic acid. We quantified lipidome plasma male female rats fed these time weaning through nine weeks age. Dietary composition determined circulating content. Exposure to was arachidonic acid-derived pro-nociceptive reduction omega-3 PUFAs. Our findings provide mechanistic insights into exaggerated hypersensitivity excessive highlight potential biomarkers stratification.

Язык: Английский

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Effects of Omega-3 Polyunsaturated Fatty Acids on the Formation of Adipokines, Cytokines, and Oxylipins in Retroperitoneal Adi-Pose Tissue of Mice

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(18), С. 9904 - 9904

Опубликована: Сен. 13, 2024

Oxylipins and specialized pro-resolving lipid mediators (SPMs) derived from polyunsaturated fatty acids (PUFAs) are that coordinate an active process of inflammation resolution. While these have potential as circulating biomarkers for several disease states with inflammatory components, the source plasma oxylipins/SPMs remains a matter debate but may involve white adipose tissue (WAT). Here, we aimed to investigate what extent high or low omega (n)-3 PUFA enrichment affects production cytokines adipokines (RT-PCR), well (liquid chromatography-tandem mass spectrometry) in WAT mice during lipopolysaccharide (LPS)-induced systemic (intraperitoneal injection, 2.5 mg/kg, 24 h). For this purpose, n-3 genetically enriched (FAT-1), which endogenously synthesize PUFAs, were compared wild-type (WT) combined PUFA-sufficient deficient diets. LPS-induced resulted decreased expression most interleukin-6 WAT, whereas n-3-sufficient diet increased them diet. The n-6 arachidonic acid was FAT-1 mice, while PUFAs (eicosapentaenoic acid, docosahexaenoic acid) their metabolites (oxylipins/SPMs) by genetic nutritional enrichment. Several LPS treatment PBS-treated controls mice. Overall, show significantly contribute oxylipin production. Moreover, n-3-deficient diets alter adipokine precise interplay between cytokines, adipokines, oxylipins be further investigated.

Язык: Английский

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Omega-3 Fatty Acids and Traumatic Injury in the Adult and Immature Brain

Nutrients, Год журнала: 2024, Номер 16(23), С. 4175 - 4175

Опубликована: Ноя. 30, 2024

Traumatic brain injury (TBI) can lead to substantial disability and health loss. Despite its importance impact worldwide, no treatment options are currently available help protect or preserve structure function following injury. In this review, we discuss the potential benefits of using omega-3 polyunsaturated fatty acids (O3 PUFAs) as therapeutic agents in context TBI paediatric adult populations.

Язык: Английский

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