Journal of Clinical Medicine, Год журнала: 2024, Номер 13(24), С. 7753 - 7753
Опубликована: Дек. 19, 2024
Atrial fibrillation (AF) and cancer are increasingly recognized as interrelated conditions, with patients showing elevated incidences of AF, there is evidence that AF may sometimes precede diagnoses. This comprehensive review investigates the epidemiology, pathophysiology, management challenges associated in patients. Epidemiologically, several cancers more closely related to increased rates including lung, colorectal, gastrointestinal, hematologic malignancies. Mechanistically, both share pathophysiological pathways centered on inflammation, oxidative stress, common cardiovascular risk factors, such hypertension, obesity, diabetes. The inflammatory microenvironment tumors, marked by cytokines growth promotes atrial remodeling susceptibility. Elevated reactive oxygen species (ROS) levels, driven metabolic demands cancer, further contribute fibrosis structural changes. Moreover, many anticancer treatments exacerbate risk. Management presents unique requires a multidisciplinary approach. Rate rhythm control strategies complicated potential drug–drug interactions limited data surrounding early implementation Interventional approaches catheter ablation, though effective maintaining sinus rhythm, carry significant perioperative malignancy. Stroke prevention anticoagulants essential but cautious administration avoid heightened bleeding risks, particularly undergoing chemotherapy. Further, applicability standard stratification tools like CHA2DS2-VASc this population complicate decisions regarding anticoagulation. highlights bidirectional relationship between difficulties management, critical need for research field.
Язык: Английский