The feasibility of artificial consciousness through the lens of neuroscience

Trends in Neurosciences, Год журнала: 2023, Номер 46(12), С. 1008 - 1017

Опубликована: Окт. 18, 2023

Язык: Английский

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Thalamic contributions to the state and contents of consciousness

Neuron, Год журнала: 2024, Номер 112(10), С. 1611 - 1625

Опубликована: Май 1, 2024

Consciousness can be conceptualized as varying along at least two dimensions: the global state of consciousness and content conscious experience. Here, we highlight cellular systems-level contributions thalamus to then argue for thalamic content, including integrated, segregated, continuous nature our We underscore vital, yet distinct roles core- matrix-type neurons. Through reciprocal interactions with deep-layer cortical neurons, matrix neurons support wakefulness determine perceptual thresholds, whereas core maintain enable constancy. further propose that integration, segregation, continuity depend on convergent corticothalamic projections enabling dimensionality reduction, a reticular nucleus-mediated divisive normalization-like process, sustained coherent activity in thalamocortical loops, respectively. Overall, conclude plays central topological role brain structures controlling

Язык: Английский

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The non-specific matrix thalamus facilitates the cortical information processing modes relevant for conscious awareness

Cell Reports, Год журнала: 2023, Номер 42(8), С. 112844 - 112844

Опубликована: Июль 25, 2023

The neurobiological mechanisms of arousal and anesthesia remain poorly understood. Recent evidence highlights the key role interactions between cerebral cortex diffusely projecting matrix thalamic nuclei. Here, we interrogate these processes in a whole-brain corticothalamic neural mass model endowed with targeted thalamocortical nuclei inferred from empirical data. This captures features seen propofol anesthesia, including diminished network integration, lowered state diversity, impaired susceptibility to perturbation, decreased corticocortical coherence. Collectively, signatures reflect suppression information transfer across cortex. We recover conscious by selectively stimulating thalamus, recapitulating results macaque, as well wake-like processing states that modulation large-scale cortical attractor dynamics. Our highlight projections shaping many complex dynamics facilitate unique communication supporting awareness.

Язык: Английский

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Correlation between brain activity and comfort at different illuminances based on electroencephalogram signals during reading

Building and Environment, Год журнала: 2024, Номер 261, С. 111694 - 111694

Опубликована: Июнь 7, 2024

Язык: Английский

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A thalamocortical substrate for integrated information via critical synchronous bursting

Proceedings of the National Academy of Sciences, Год журнала: 2023, Номер 120(46)

Опубликована: Ноя. 8, 2023

Understanding the neurobiological mechanisms underlying consciousness remains a significant challenge. Recent evidence suggests that coupling between distal–apical and basal–somatic dendrites in thick-tufted layer 5 pyramidal neurons (L5 PN ), regulated by nonspecific-projecting thalamus, is crucial for consciousness. Yet, it uncertain whether this thalamocortical mechanism can support emergent signatures of consciousness, such as integrated information. To address question, we constructed biophysical network dual-compartment L5 , with dendrosomatic controlled thalamic inputs. Our findings demonstrate information maximized when nonspecific inputs drive system into regime time-varying synchronous bursting. Here, exhibits variable spiking dynamics broad pairwise correlations, supporting enhanced Further, observed peak aligns criticality empirically bursting rates. These results suggest core mammalian brain may be evolutionarily configured to optimize effective processing, providing potential neuronal integrates microscale theories macroscale

Язык: Английский

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Causal evidence for cholinergic stabilization of attractor landscape dynamics

Cell Reports, Год журнала: 2024, Номер 43(6), С. 114359 - 114359

Опубликована: Июнь 1, 2024

There is substantial evidence that neuromodulatory systems critically influence brain state dynamics; however, most work has been purely descriptive. Here, we quantify, using data combining local inactivation of the basal forebrain with simultaneous measurement resting-state fMRI activity in macaque, causal role long-range cholinergic input to stabilization states cerebral cortex. Local nucleus basalis Meynert (nbM) leads a decrease energy barriers required for an transition cortical ongoing activity. Moreover, particular nbM sub-regions predominantly affects information transfer regions known receive direct anatomical projections. We demonstrate these results simple neurodynamical model impact on neuronal firing rates and slow hyperpolarizing adaptation currents. conclude system plays critical stabilizing macroscale dynamics.

Язык: Английский

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The effect of the preferred illuminance on dynamic features of the brain activity during reading

Journal of Building Engineering, Год журнала: 2025, Номер 103, С. 112064 - 112064

Опубликована: Фев. 7, 2025

Язык: Английский

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Context‐Sensitive Conscious Interpretation and Layer‐5 Pyramidal Neurons in Multistable Perception

Brain and Behavior, Год журнала: 2025, Номер 15(3)

Опубликована: Март 1, 2025

There appears to be a fundamental difference between the two ways of how an object becomes perceptually experienced. One occurs when preconscious object-specifying sensory data processing crosses certain threshold so that constituents depiction become consciously The other already experienced features interpreted as belonging visual category. Surprisingly, experimental facts about neural markers conscious access gathered far do not allow us distinguish mechanisms responsible for these varieties. A cortical multicompartment layer-5 pyramidal neuron-based generic model is presented in order conceptualize possible mechanistic solution explanatory cul-de-sac. To support argument, review pertinent research compiled associated with from studies where physically invariant perceptual stimuli have underwent alternative interpretation(s) by brain. Recent developments newly emerging field cellular psycho(physio)logy are introduced, offering hypothetical distinguishing subserving content experience and interpretation. single cell-based approach brain process correlates perception added value beyond traditional inter-areal connectivity-based theoretical stances.

Язык: Английский

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The brain that controls itself

Current Opinion in Behavioral Sciences, Год журнала: 2025, Номер 63, С. 101499 - 101499

Опубликована: Март 12, 2025

Язык: Английский

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Beyond Mechanism—Extending Our Concepts of Causation in Neuroscience

European Journal of Neuroscience, Год журнала: 2025, Номер 61(5)

Опубликована: Март 1, 2025

ABSTRACT In neuroscience, the search for causes of behaviour is often just taken to be neural mechanisms. This view typically involves three forms causal reduction: first, from ontological level cognitive processes that mechanisms; second, activity whole brain isolated parts; and third, a consideration temporally extended, historical focus on synchronic states. While modern neuroscience has made impressive progress in identifying mechanisms, providing unprecedented real‐time control behaviour, we contend this does not amount full explanation. particular, there an attendant danger eliminating our explanatory framework, even organism itself. To fully understand need what happens when different neurons are activated, but why those things happen . paper, introduce range well‐developed, non‐reductive, extended notions causality philosophy, which neuroscientists may able draw order build more complete explanations behaviour. These include concepts criterial causation, triggering versus structuring causes, constraints, macroscopic historicity, semantic causation—all which, argue, can used undergird naturalistic understanding mental causation agent causation. can, collectively, help bring cognition itself back into picture, as unto itself, while still grounding respectable scientific terms.

Язык: Английский

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