Diverse Colonisation and Disease Associations of the Human Commensal Malassezia: Our Body's Secret Tenant DOI Open Access
Jayaprakash Sasikumar,

Rumaisa Ali Ebrahim,

Shankar Das

и другие.

Mycoses, Год журнала: 2025, Номер 68(1)

Опубликована: Янв. 1, 2025

ABSTRACT A niche in the context of microorganisms defines specific ecological role or habitat inhabited by microbial species within an ecosystem. For human commensal Malassezia , skin surface is considered its primary niche, where it adapts to environment utilising lipids as main carbon and energy source. However pathogenic characteristics include production allergens, immune modulation excessive lipid utilisation, which result several diseases such pityriasis versicolor, seborrheic dermatitis, folliculitis atopic dermatitis. Recent studies have revealed colonisation internal organs, including lungs, gut, genitourinary tract, eyes, ears breast milk. In these associated with linked respiratory conditions, neurological disorders, gastrointestinal genital infections. The system plays a critical shaping prevalence, factors like, suppressive drugs underlying health conditions influencing susceptibility. Accurate diagnosis ‐related disorders challenging due unique growth requirements, but molecular fingerprinting assays sequencing methods, particularly ITS sequencing, offer precise identification. Treatment involves antifungal drugs, corticosteroids phytocompounds, yet recurrent infections highlight need for more targeted therapeutic strategies addressing 's characteristics. Understanding complex interactions between host organs crucial diagnosis, treatment prevention exploring potentially beneficial roles disease. This review highlights current findings on intricate diverse ecosystem body, underscoring complexity associations emphasising their multifaceted

Язык: Английский

Mood and microbes: a comprehensive review of intestinal microbiota’s impact on depression DOI Creative Commons

Ameer Luqman,

Mei He, Adil Hassan

и другие.

Frontiers in Psychiatry, Год журнала: 2024, Номер 15

Опубликована: Фев. 9, 2024

Depression is considered a multifaceted and intricate mental disorder of growing concern due to its significant impact on global health issues. The human gut microbiota, also known as the “second brain,” has an important role in CNS by regulating it through chemical, immunological, hormonal, neurological processes. Various studies have found bidirectional link between brain gut, emphasizing onset depression therapies. biological molecular processes underlying microbiota are required, association may represent novel study. However, profound insights into stratification diversity still uncommon. This article investigates emerging evidence bacterial relationship brain’s system potential pathogenicity relevance. interplay immune system, nervous neurotransmitter synthesis, neuroplasticity transitions widely studied. consequences stress, dietary fibers, probiotics, prebiotics, antibiotics GB axis being Multiple revealed this led development effective microbiota-based drugs for both prevention treatment. Therefore, results support hypothesis that influences provide promising area research improved knowledge etiology disease future

Язык: Английский

Процитировано

11
Metabolic tug-of-war: Microbial metabolism shapes colonization resistance against enteric pathogens DOI

Katerina Jones,

Camila Bernardo de Brito, Mariana X. Byndloss

и другие.

Cell chemical biology, Год журнала: 2025, Номер 32(1), С. 46 - 60

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2
Steatotic Liver Disease in Younger Adults is Associated With Altered Gut Microbiology DOI Creative Commons

Yasmina Tashkent,

Jocelyn M. Choo,

Alyson Richard

и другие.

Liver International, Год журнала: 2025, Номер 45(3)

Опубликована: Фев. 25, 2025

ABSTRACT Background and Aims Steatotic liver disease (SLD) is a leading cause of chronic worldwide. As SLD pathogenesis has been linked to gut microbiome alterations, we aimed identify SLD‐associated features early in development by utilising highly characterised cohort community‐dwelling younger adults. Methods Results At age 27 years, 588 participants the Raine Study Generation 2 underwent cross‐sectional assessment. Hepatic steatosis was quantified using validated magnetic resonance imaging (MRI) volumetric fat fraction (VLFF) equation (HepaFat). Of participants, 488 (83%) were classified as having ‘no SLD’ (VLFF ≤ 3.55%), 76 (12.9%) with ‘mild–moderate’ (VLFF: 3.56%–13.4%) 24 (4.10%) ‘severe’ > 13.4%). Stool profiling identified an association between severe lower microbiota alpha diversity (observed [ p = 0.015], Pielou evenness 0.001] Shannon 0.002]) compared no SLD. Faecal composition differed significantly both mild–moderate ( 0.004) groups 0.001). There significant difference dispersion groups. Reduced relative abundance short‐chain fatty acid producing bacteria, higher levels proinflammatory bacterial taxa, associated q < 0.05). Conclusions adults reduced intestinal microbial pattern taxa depletion that consistent other inflammatory conditions. Our characterisation characteristics provides potential basis for risk identification reduction. Trial Registration The registered Australian New Zealand Clinical Trials Registry (ACTRN12617001599369)

Язык: Английский

Процитировано

2
The role of polysaccharides in immune regulation through gut microbiota: mechanisms and implications DOI Creative Commons
Ting Zhao, Congyue Wang, Yuhan Liu

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 31, 2025

Polysaccharides, as complex carbohydrates, play a pivotal role in immune modulation and interactions with the gut microbiota. The diverse array of dietary polysaccharides influences microbial ecology, impacting responses, metabolism, overall well-being. Despite their recognized benefits, there is limited understanding precise mechanisms by which modulate system through A comprehensive search Web Science, PubMed, Google Scholar, Embase up to May 2024 was conducted identify relevant studies. This study employs systematic approach explore interplay between microbiota, focusing on cytokine-mediated short-chain fatty acid (SCFA)-mediated pathways. findings underscore significant shaping composition function thereby influencing regulation metabolic processes. However, further research necessary elucidate detailed molecular translate these into clinical applications.

Язык: Английский

Процитировано

2
Oxidative Stress, Gut Microbiota, and Extracellular Vesicles: Interconnected Pathways and Therapeutic Potentials DOI Open Access
Bo Ma, Muttiah Barathan, Min Hwei Ng

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3148 - 3148

Опубликована: Март 28, 2025

Oxidative stress (OS) and gut microbiota are crucial factors influencing human health, each playing a significant role in the development progression of chronic diseases. This review provides comprehensive analysis complex interplay between these two factors, focusing on how an imbalance reactive oxygen species (ROS) antioxidants leads to OS, disrupting cellular homeostasis contributing range conditions, including metabolic disorders, cardiovascular diseases, neurological cancer. The microbiota, diverse community microorganisms residing gastrointestinal tract, is essential for regulating immune responses, pathways, overall health. Dysbiosis, composition, closely associated with inflammation, dysfunction, various highlights influences influenced by complicating pathophysiology many conditions. Furthermore, emerging evidence has identified extracellular vesicles (EVs) as critical facilitators crosstalk OS microbiota. EVs also play signaling host tissues, modulating processes. function holds promise targeted therapies aimed at restoring microbial balance mitigating OS. Personalized therapeutic approaches, probiotics, antioxidants, fecal transplantation-based strategies, can be used address OS-related diseases improve health outcomes. Nonetheless, further research needed study molecular mechanisms underlying interactions potential innovative interventions offer novel strategies managing enhancing

Язык: Английский

Процитировано

2
Effects of Cordyceps cicadae Polysaccharide on Gut Microbiota, the Intestinal Mucosal Barrier, and Inflammation in Diabetic Mice DOI Creative Commons
Liangdan Sun,

Huaibo Yuan,

Huiqing Ma

и другие.

Metabolites, Год журнала: 2025, Номер 15(1), С. 8 - 8

Опубликована: Янв. 1, 2025

Background: Polysaccharides produced by the edible fungus Cordyceps cicadae can regulate blood sugar levels and may represent a suitable candidate for treatment of diabetes its complications. However, there is limited information available about mechanism how C. polysaccharide (CCP) might improve diabetic conditions. Methods: This study investigated effects on intestinal microbiota, mucosal barrier, inflammation in mice with type 2 mellitus (T2DM) induced streptozotocin, potential mechanisms. Results: Compared DC (diabetes model control group), CCPH oral significantly increased number beneficial bifidobacteria, lactobacilli (p < 0.01), restored diversity microorganisms mice, proportions Firmicutes Bacteroidetes (34.36%/54.65%) were lower than those (52.15%/32.09%). Moreover, reduced content endotoxin (lipopolysaccharide, LPS) D-lactic acid(D-LA) 0.05), activities antioxidant enzymes total capacity proinflammatory cytokines TNF-α, IL-6, IL-1β 42.05%, 51.28%, 52.79%, respectively, compared DC. The TLR4/NF-κB signaling pathway, as therapeutic target diseases, plays role regulating inflammatory response protecting barrier function. Molecular studies showed that down-regulated expression NF-κB, TLR-4, TNF-α genes 18.66%, 21.58%, 34.87%, while up-regulating ZO-1 occludin 32.70% 25.11%, respectively. regulates short-chain fatty acid levels, increases microbial diversity, ameliorates mouse colon lesions inhibiting pathway. Conclusions: In conclusion, it demonstrated this murine model, effectively microbiota imbalance, protect function, reduce vivo, suggesting natural product provide strategy T2D-induced gut dysbiosis health.

Язык: Английский

Процитировано

1
The Role of Gut Microbiota-derived Short Chain Fatty Acids in Amyotrophic Lateral Sclerosis DOI
Mohamed J. Saadh, Shahad Mohammed Dhiaa, Pooja Bansal

и другие.

Current Behavioral Neuroscience Reports, Год журнала: 2025, Номер 12(1)

Опубликована: Янв. 25, 2025

Язык: Английский

Процитировано

1
High Altitude Microbiome: Insight into Yak Gut Microbiota and its Nutritional and Functional Involvement for Food Systems DOI
Muhammad Fakhar‐e‐Alam Kulyar, Quan Mo, Shah Nawaz

и другие.

Trends in Food Science & Technology, Год журнала: 2025, Номер unknown, С. 104897 - 104897

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Deciphering the Structural and Functional Paradigms of Clostridioides difficile Toxins TcdA and TcdB DOI Creative Commons

Mohammad Qutub,

Amol Tatode, Ujban Hussain

и другие.

Bacteria, Год журнала: 2025, Номер 4(2), С. 21 - 21

Опубликована: Апрель 3, 2025

Clostridioides difficile Infection (CDI) continues to be a major cause of antibiotic-associated diarrhea and pseudomembranous colitis, fueled in large measure by virulence factors TcdA TcdB. These giant glucosyltransferase toxins interfere with host cytoskeletal integrity inflammatory signaling inhibiting Rho GTPase; however, the detailed structural dynamics, receptor selectivity, subcellular trafficking mechanisms remain part unspecified. This review integrates recent insights from cryo-electron microscopy (cryo-EM) X-ray crystallography describe quaternary architecture TcdA/B, emphasizing conformational changes key pore formation endosomal escape. We also examine genomic heterogeneity hypervirulent C. strains (e.g., ribotype 027), correlating toxin gene polymorphisms tcdC mutations) increased production virulence. Mechanistic explanations toxin-driven inflammasome activation epithelial barrier dysfunction are situated within immune evasion mechanisms, including microbiota-derived bile acid regulation stability. Subsequent innovative therapeutic strategies, encompassing utilization engineered neutralizing antibodies that specifically target autoprocessing domain alongside structure-guided small-molecule inhibitors, subjected rigorous evaluation. By integrating biology, systems-level omics, clinical epidemiology, this establishes comprehensive framework for understanding pathogenesis guiding next-generation precision antimicrobials.

Язык: Английский

Процитировано

1
The role and mechanism of action of microbiota-derived short-chain fatty acids in neutrophils: From the activation to becoming potential biomarkers DOI Open Access

Qingzhu Yan,

Shengnan Jia,

Dongfu Li

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 169, С. 115821 - 115821

Опубликована: Ноя. 10, 2023

Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, have emerged critical mediators in the communication between human microbiota its host. As first responder to inflammatory site, neutrophils play an important role protecting host against bacterial infections. Recent investigations revealed that SCFAs generated from influence various neutrophil activities, including activation, migration, generation of processes. also been demonstrated exhibit potential therapeutic benefits a variety disorders related dysfunction, bowel disease, viral infectious disorders, cancer. This study aims examine molecular processes behind complicated link neutrophils, well their on neutrophil-driven disorders. In addition, we will provide in-depth review current research diagnostic value possible biomarkers for neutrophil-related diseases.

Язык: Английский

Процитировано

18