Journal of Diabetes and its Complications, Год журнала: 2025, Номер 39(2), С. 108954 - 108954
Опубликована: Янв. 22, 2025
Язык: Английский
Cancer Letters, Год журнала: 2024, Номер 598, С. 217096 - 217096
Опубликована: Июль 4, 2024
Язык: Английский
Процитировано
14
Frontiers in Psychiatry, Год журнала: 2024, Номер 15
Опубликована: Фев. 9, 2024
Depression is considered a multifaceted and intricate mental disorder of growing concern due to its significant impact on global health issues. The human gut microbiota, also known as the “second brain,” has an important role in CNS by regulating it through chemical, immunological, hormonal, neurological processes. Various studies have found bidirectional link between brain gut, emphasizing onset depression therapies. biological molecular processes underlying microbiota are required, association may represent novel study. However, profound insights into stratification diversity still uncommon. This article investigates emerging evidence bacterial relationship brain’s system potential pathogenicity relevance. interplay immune system, nervous neurotransmitter synthesis, neuroplasticity transitions widely studied. consequences stress, dietary fibers, probiotics, prebiotics, antibiotics GB axis being Multiple revealed this led development effective microbiota-based drugs for both prevention treatment. Therefore, results support hypothesis that influences provide promising area research improved knowledge etiology disease future
Язык: Английский
Процитировано
11
Cell chemical biology, Год журнала: 2025, Номер 32(1), С. 46 - 60
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
Liver International, Год журнала: 2025, Номер 45(3)
Опубликована: Фев. 25, 2025
ABSTRACT Background and Aims Steatotic liver disease (SLD) is a leading cause of chronic worldwide. As SLD pathogenesis has been linked to gut microbiome alterations, we aimed identify SLD‐associated features early in development by utilising highly characterised cohort community‐dwelling younger adults. Methods Results At age 27 years, 588 participants the Raine Study Generation 2 underwent cross‐sectional assessment. Hepatic steatosis was quantified using validated magnetic resonance imaging (MRI) volumetric fat fraction (VLFF) equation (HepaFat). Of participants, 488 (83%) were classified as having ‘no SLD’ (VLFF ≤ 3.55%), 76 (12.9%) with ‘mild–moderate’ (VLFF: 3.56%–13.4%) 24 (4.10%) ‘severe’ > 13.4%). Stool profiling identified an association between severe lower microbiota alpha diversity (observed [ p = 0.015], Pielou evenness 0.001] Shannon 0.002]) compared no SLD. Faecal composition differed significantly both mild–moderate ( 0.004) groups 0.001). There significant difference dispersion groups. Reduced relative abundance short‐chain fatty acid producing bacteria, higher levels proinflammatory bacterial taxa, associated q < 0.05). Conclusions adults reduced intestinal microbial pattern taxa depletion that consistent other inflammatory conditions. Our characterisation characteristics provides potential basis for risk identification reduction. Trial Registration The registered Australian New Zealand Clinical Trials Registry (ACTRN12617001599369)
Язык: Английский
Процитировано
2
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Март 31, 2025
Polysaccharides, as complex carbohydrates, play a pivotal role in immune modulation and interactions with the gut microbiota. The diverse array of dietary polysaccharides influences microbial ecology, impacting responses, metabolism, overall well-being. Despite their recognized benefits, there is limited understanding precise mechanisms by which modulate system through A comprehensive search Web Science, PubMed, Google Scholar, Embase up to May 2024 was conducted identify relevant studies. This study employs systematic approach explore interplay between microbiota, focusing on cytokine-mediated short-chain fatty acid (SCFA)-mediated pathways. findings underscore significant shaping composition function thereby influencing regulation metabolic processes. However, further research necessary elucidate detailed molecular translate these into clinical applications.
Язык: Английский
Процитировано
2
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 169, С. 115821 - 115821
Опубликована: Ноя. 10, 2023
Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, have emerged critical mediators in the communication between human microbiota its host. As first responder to inflammatory site, neutrophils play an important role protecting host against bacterial infections. Recent investigations revealed that SCFAs generated from influence various neutrophil activities, including activation, migration, generation of processes. also been demonstrated exhibit potential therapeutic benefits a variety disorders related dysfunction, bowel disease, viral infectious disorders, cancer. This study aims examine molecular processes behind complicated link neutrophils, well their on neutrophil-driven disorders. In addition, we will provide in-depth review current research diagnostic value possible biomarkers for neutrophil-related diseases.
Язык: Английский
Процитировано
18
Environmental Pollution, Год журнала: 2024, Номер 359, С. 124742 - 124742
Опубликована: Авг. 15, 2024
Язык: Английский
Процитировано
9
Phytomedicine, Год журнала: 2024, Номер 128, С. 155413 - 155413
Опубликована: Фев. 4, 2024
Язык: Английский
Процитировано
8
Microbiome, Год журнала: 2024, Номер 12(1)
Опубликована: Окт. 21, 2024
The disease resistance phenotype is closely related to immunomodulatory function and immune tolerance has far-reaching implications in animal husbandry human health. Microbes play an important role the initiation, prevention, treatment of diseases, but mechanisms host-microbiota interactions disease-resistant phenotypes are poorly understood. In this study, we hope uncover explain microbes intestinal diseases their action identify new potential treatments.
Язык: Английский
Процитировано
8
Designed Monomers & Polymers, Год журнала: 2024, Номер 28(1), С. 1 - 34
Опубликована: Дек. 31, 2024
This review paper analyzes recent advancements in bio-polymer coatings for probiotic microencapsulation, with a particular emphasis on chitosan and its synergistic combinations other materials. Probiotic microencapsulation is essential protecting probiotics from environmental stresses, enhancing their stability, ensuring effective delivery to the gut. The begins an overview of highlighting significance safeguarding through processing, storage, gastrointestinal transit. Advances chitosan-based encapsulation are explored, including integration bio-polymers such as alginate, gelatin, pectin, well application nanotechnology innovative techniques like spray drying layer-by-layer assembly. Detailed mechanistic insights integrated, illustrating how influences gut microbiota by promoting beneficial bacteria suppressing pathogens, thus role prebiotic or synbiotic. Furthermore, delves into chitosan's immunomodulatory effects, particularly context inflammatory bowel disease (IBD) autoimmune diseases, describing immune signaling pathways influenced linking changes improvements systemic immunity. Recent clinical trials human studies assessing efficacy chitosan-coated presented, alongside discussion practical applications comparison vitro vivo findings highlight real-world relevance. sustainability sources impact addressed, along novel concept gut-brain axis. Finally, emphasizes future research needs, development personalized therapies exploration techniques.
Язык: Английский
Процитировано
8