Artificial sweeteners and Type 2 Diabetes Mellitus: A review of current developments and future research directions DOI

Francisca Obianuju Okoro,

Victor Markus

Journal of Diabetes and its Complications, Год журнала: 2025, Номер 39(2), С. 108954 - 108954

Опубликована: Янв. 22, 2025

Язык: Английский

Gut microbial metabolites in lung cancer development and immunotherapy: Novel insights into gut-lung axis DOI
Xinpei Li,

Shijie Shang,

Meng Wu

и другие.

Cancer Letters, Год журнала: 2024, Номер 598, С. 217096 - 217096

Опубликована: Июль 4, 2024

Язык: Английский

Процитировано

14

Mood and microbes: a comprehensive review of intestinal microbiota’s impact on depression DOI Creative Commons

Ameer Luqman,

Mei He, Adil Hassan

и другие.

Frontiers in Psychiatry, Год журнала: 2024, Номер 15

Опубликована: Фев. 9, 2024

Depression is considered a multifaceted and intricate mental disorder of growing concern due to its significant impact on global health issues. The human gut microbiota, also known as the “second brain,” has an important role in CNS by regulating it through chemical, immunological, hormonal, neurological processes. Various studies have found bidirectional link between brain gut, emphasizing onset depression therapies. biological molecular processes underlying microbiota are required, association may represent novel study. However, profound insights into stratification diversity still uncommon. This article investigates emerging evidence bacterial relationship brain’s system potential pathogenicity relevance. interplay immune system, nervous neurotransmitter synthesis, neuroplasticity transitions widely studied. consequences stress, dietary fibers, probiotics, prebiotics, antibiotics GB axis being Multiple revealed this led development effective microbiota-based drugs for both prevention treatment. Therefore, results support hypothesis that influences provide promising area research improved knowledge etiology disease future

Язык: Английский

Процитировано

11

Metabolic tug-of-war: Microbial metabolism shapes colonization resistance against enteric pathogens DOI

Katerina Jones,

Camila Bernardo de Brito, Mariana X. Byndloss

и другие.

Cell chemical biology, Год журнала: 2025, Номер 32(1), С. 46 - 60

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2

Steatotic Liver Disease in Younger Adults is Associated With Altered Gut Microbiology DOI Creative Commons

Yasmina Tashkent,

Jocelyn M. Choo,

Alyson Richard

и другие.

Liver International, Год журнала: 2025, Номер 45(3)

Опубликована: Фев. 25, 2025

ABSTRACT Background and Aims Steatotic liver disease (SLD) is a leading cause of chronic worldwide. As SLD pathogenesis has been linked to gut microbiome alterations, we aimed identify SLD‐associated features early in development by utilising highly characterised cohort community‐dwelling younger adults. Methods Results At age 27 years, 588 participants the Raine Study Generation 2 underwent cross‐sectional assessment. Hepatic steatosis was quantified using validated magnetic resonance imaging (MRI) volumetric fat fraction (VLFF) equation (HepaFat). Of participants, 488 (83%) were classified as having ‘no SLD’ (VLFF ≤ 3.55%), 76 (12.9%) with ‘mild–moderate’ (VLFF: 3.56%–13.4%) 24 (4.10%) ‘severe’ > 13.4%). Stool profiling identified an association between severe lower microbiota alpha diversity (observed [ p = 0.015], Pielou evenness 0.001] Shannon 0.002]) compared no SLD. Faecal composition differed significantly both mild–moderate ( 0.004) groups 0.001). There significant difference dispersion groups. Reduced relative abundance short‐chain fatty acid producing bacteria, higher levels proinflammatory bacterial taxa, associated q < 0.05). Conclusions adults reduced intestinal microbial pattern taxa depletion that consistent other inflammatory conditions. Our characterisation characteristics provides potential basis for risk identification reduction. Trial Registration The registered Australian New Zealand Clinical Trials Registry (ACTRN12617001599369)

Язык: Английский

Процитировано

2

The role of polysaccharides in immune regulation through gut microbiota: mechanisms and implications DOI Creative Commons
Ting Zhao, Congyue Wang, Yuhan Liu

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 31, 2025

Polysaccharides, as complex carbohydrates, play a pivotal role in immune modulation and interactions with the gut microbiota. The diverse array of dietary polysaccharides influences microbial ecology, impacting responses, metabolism, overall well-being. Despite their recognized benefits, there is limited understanding precise mechanisms by which modulate system through A comprehensive search Web Science, PubMed, Google Scholar, Embase up to May 2024 was conducted identify relevant studies. This study employs systematic approach explore interplay between microbiota, focusing on cytokine-mediated short-chain fatty acid (SCFA)-mediated pathways. findings underscore significant shaping composition function thereby influencing regulation metabolic processes. However, further research necessary elucidate detailed molecular translate these into clinical applications.

Язык: Английский

Процитировано

2

The role and mechanism of action of microbiota-derived short-chain fatty acids in neutrophils: From the activation to becoming potential biomarkers DOI Open Access

Qingzhu Yan,

Shengnan Jia,

Dongfu Li

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 169, С. 115821 - 115821

Опубликована: Ноя. 10, 2023

Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, have emerged critical mediators in the communication between human microbiota its host. As first responder to inflammatory site, neutrophils play an important role protecting host against bacterial infections. Recent investigations revealed that SCFAs generated from influence various neutrophil activities, including activation, migration, generation of processes. also been demonstrated exhibit potential therapeutic benefits a variety disorders related dysfunction, bowel disease, viral infectious disorders, cancer. This study aims examine molecular processes behind complicated link neutrophils, well their on neutrophil-driven disorders. In addition, we will provide in-depth review current research diagnostic value possible biomarkers for neutrophil-related diseases.

Язык: Английский

Процитировано

18

The role of gut microbiota in MP/NP-induced toxicity DOI

Yinping Pan,

Haojie Zhang, Liancai Zhu

и другие.

Environmental Pollution, Год журнала: 2024, Номер 359, С. 124742 - 124742

Опубликована: Авг. 15, 2024

Язык: Английский

Процитировано

9

Gut microbiota-dependent modulation of pre-metastatic niches by Jianpi Yangzheng decoction in the prevention of lung metastasis of gastric cancer DOI
Xiaofei Zhu, Xingxing Zhang,

Junyu Shen

и другие.

Phytomedicine, Год журнала: 2024, Номер 128, С. 155413 - 155413

Опубликована: Фев. 4, 2024

Язык: Английский

Процитировано

8

Host–microbe interaction-mediated resistance to DSS-induced inflammatory enteritis in sheep DOI Creative Commons

Shuo Yan,

Ruilin Du,

Wenna Yao

и другие.

Microbiome, Год журнала: 2024, Номер 12(1)

Опубликована: Окт. 21, 2024

The disease resistance phenotype is closely related to immunomodulatory function and immune tolerance has far-reaching implications in animal husbandry human health. Microbes play an important role the initiation, prevention, treatment of diseases, but mechanisms host-microbiota interactions disease-resistant phenotypes are poorly understood. In this study, we hope uncover explain microbes intestinal diseases their action identify new potential treatments.

Язык: Английский

Процитировано

8

Advances in bio-polymer coatings for probiotic microencapsulation: chitosan and beyond for enhanced stability and controlled release DOI Creative Commons
Great Iruoghene Edo, Alice Njolke Mafe,

Nawar. F. Razooqi

и другие.

Designed Monomers & Polymers, Год журнала: 2024, Номер 28(1), С. 1 - 34

Опубликована: Дек. 31, 2024

This review paper analyzes recent advancements in bio-polymer coatings for probiotic microencapsulation, with a particular emphasis on chitosan and its synergistic combinations other materials. Probiotic microencapsulation is essential protecting probiotics from environmental stresses, enhancing their stability, ensuring effective delivery to the gut. The begins an overview of highlighting significance safeguarding through processing, storage, gastrointestinal transit. Advances chitosan-based encapsulation are explored, including integration bio-polymers such as alginate, gelatin, pectin, well application nanotechnology innovative techniques like spray drying layer-by-layer assembly. Detailed mechanistic insights integrated, illustrating how influences gut microbiota by promoting beneficial bacteria suppressing pathogens, thus role prebiotic or synbiotic. Furthermore, delves into chitosan's immunomodulatory effects, particularly context inflammatory bowel disease (IBD) autoimmune diseases, describing immune signaling pathways influenced linking changes improvements systemic immunity. Recent clinical trials human studies assessing efficacy chitosan-coated presented, alongside discussion practical applications comparison vitro vivo findings highlight real-world relevance. sustainability sources impact addressed, along novel concept gut-brain axis. Finally, emphasizes future research needs, development personalized therapies exploration techniques.

Язык: Английский

Процитировано

8