Metabolomics, Journal Year: 2024, Volume and Issue: 20(5)
Published: Sept. 6, 2024
Language: Английский
Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 9, 2024
Depression is considered a multifaceted and intricate mental disorder of growing concern due to its significant impact on global health issues. The human gut microbiota, also known as the “second brain,” has an important role in CNS by regulating it through chemical, immunological, hormonal, neurological processes. Various studies have found bidirectional link between brain gut, emphasizing onset depression therapies. biological molecular processes underlying microbiota are required, association may represent novel study. However, profound insights into stratification diversity still uncommon. This article investigates emerging evidence bacterial relationship brain’s system potential pathogenicity relevance. interplay immune system, nervous neurotransmitter synthesis, neuroplasticity transitions widely studied. consequences stress, dietary fibers, probiotics, prebiotics, antibiotics GB axis being Multiple revealed this led development effective microbiota-based drugs for both prevention treatment. Therefore, results support hypothesis that influences provide promising area research improved knowledge etiology disease future
Language: Английский
Citations
11
Cancer Letters, Journal Year: 2024, Volume and Issue: 598, P. 217096 - 217096
Published: July 4, 2024
Language: Английский
Citations
11
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8250 - 8250
Published: July 28, 2024
The intricate relationship between the gastrointestinal (GI) microbiome and progression of chronic non-communicable diseases underscores significance developing strategies to modulate GI microbiota for promoting human health. administration probiotics prebiotics represents a good strategy that enhances population beneficial bacteria in intestinal lumen post-consumption, which has positive impact on In addition, dietary fibers serve as significant energy source inhabiting cecum colon. Research articles reviews sourced from various global databases were systematically analyzed using specific phrases keywords investigate these relationships. There is clear association fiber intake improved colon function, gut motility, reduced colorectal cancer (CRC) risk. Moreover, state health reflected reciprocal bidirectional relationships among food, antioxidants, inflammation, body composition. They are known their antioxidant properties ability inhibit angiogenesis, metastasis, cell proliferation. Additionally, they promote survival, immune inflammatory responses, inactivate pro-carcinogens. These actions collectively contribute role prevention. different investigations, supplements containing vitamins have been shown lower risk types. contrast, some evidence suggests taking can increase cancer. Ultimately, collaborative efforts immunologists, clinicians, nutritionists, dietitians imperative designing well-structured nutritional trials corroborate clinical efficacy therapy managing inflammation preventing carcinogenesis. This review seeks explore interrelationships fiber, microbiome, with particular focus potential implications
Language: Английский
Citations
11
Metabolites, Journal Year: 2025, Volume and Issue: 15(1), P. 8 - 8
Published: Jan. 1, 2025
Background: Polysaccharides produced by the edible fungus Cordyceps cicadae can regulate blood sugar levels and may represent a suitable candidate for treatment of diabetes its complications. However, there is limited information available about mechanism how C. polysaccharide (CCP) might improve diabetic conditions. Methods: This study investigated effects on intestinal microbiota, mucosal barrier, inflammation in mice with type 2 mellitus (T2DM) induced streptozotocin, potential mechanisms. Results: Compared DC (diabetes model control group), CCPH oral significantly increased number beneficial bifidobacteria, lactobacilli (p < 0.01), restored diversity microorganisms mice, proportions Firmicutes Bacteroidetes (34.36%/54.65%) were lower than those (52.15%/32.09%). Moreover, reduced content endotoxin (lipopolysaccharide, LPS) D-lactic acid(D-LA) 0.05), activities antioxidant enzymes total capacity proinflammatory cytokines TNF-α, IL-6, IL-1β 42.05%, 51.28%, 52.79%, respectively, compared DC. The TLR4/NF-κB signaling pathway, as therapeutic target diseases, plays role regulating inflammatory response protecting barrier function. Molecular studies showed that down-regulated expression NF-κB, TLR-4, TNF-α genes 18.66%, 21.58%, 34.87%, while up-regulating ZO-1 occludin 32.70% 25.11%, respectively. regulates short-chain fatty acid levels, increases microbial diversity, ameliorates mouse colon lesions inhibiting pathway. Conclusions: In conclusion, it demonstrated this murine model, effectively microbiota imbalance, protect function, reduce vivo, suggesting natural product provide strategy T2D-induced gut dysbiosis health.
Language: Английский
Citations
1
Mycoses, Journal Year: 2025, Volume and Issue: 68(1)
Published: Jan. 1, 2025
ABSTRACT A niche in the context of microorganisms defines specific ecological role or habitat inhabited by microbial species within an ecosystem. For human commensal Malassezia , skin surface is considered its primary niche, where it adapts to environment utilising lipids as main carbon and energy source. However pathogenic characteristics include production allergens, immune modulation excessive lipid utilisation, which result several diseases such pityriasis versicolor, seborrheic dermatitis, folliculitis atopic dermatitis. Recent studies have revealed colonisation internal organs, including lungs, gut, genitourinary tract, eyes, ears breast milk. In these associated with linked respiratory conditions, neurological disorders, gastrointestinal genital infections. The system plays a critical shaping prevalence, factors like, suppressive drugs underlying health conditions influencing susceptibility. Accurate diagnosis ‐related disorders challenging due unique growth requirements, but molecular fingerprinting assays sequencing methods, particularly ITS sequencing, offer precise identification. Treatment involves antifungal drugs, corticosteroids phytocompounds, yet recurrent infections highlight need for more targeted therapeutic strategies addressing 's characteristics. Understanding complex interactions between host organs crucial diagnosis, treatment prevention exploring potentially beneficial roles disease. This review highlights current findings on intricate diverse ecosystem body, underscoring complexity associations emphasising their multifaceted
Language: Английский
Citations
1
Cell chemical biology, Journal Year: 2025, Volume and Issue: 32(1), P. 46 - 60
Published: Jan. 1, 2025
Language: Английский
Citations
1
Exploration of Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 19, 2025
The gut microbiota, a complex ecosystem of microorganisms, plays an essential role in maintaining immune and metabolic homeostasis. Disruption this microbial balance, known as dysbiosis, has been increasingly implicated the pathogenesis chronic inflammatory conditions, including cardiovascular, gastrointestinal, autoimmune diseases, well disorders such diabetes obesity. A crucial mechanism through which microbiota exerts its effects on host physiology is via production bioactive metabolites. These metabolites, short-chain fatty acids, bile tryptophan derivatives, are key modulating responses regulating functions. Dysbiosis disrupts function these thereby contributing to dysregulation, inflammation, disease progression. This review examines microbiota-derived metabolites with focus their immunomodulatory effects. deeper understanding mechanisms may open way for novel therapeutic strategies aimed at restoring homeostasis mitigating global burden diseases.
Language: Английский
Citations
1
Current Behavioral Neuroscience Reports, Journal Year: 2025, Volume and Issue: 12(1)
Published: Jan. 25, 2025
Language: Английский
Citations
1
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 169, P. 115821 - 115821
Published: Nov. 10, 2023
Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, have emerged critical mediators in the communication between human microbiota its host. As first responder to inflammatory site, neutrophils play an important role protecting host against bacterial infections. Recent investigations revealed that SCFAs generated from influence various neutrophil activities, including activation, migration, generation of processes. also been demonstrated exhibit potential therapeutic benefits a variety disorders related dysfunction, bowel disease, viral infectious disorders, cancer. This study aims examine molecular processes behind complicated link neutrophils, well their on neutrophil-driven disorders. In addition, we will provide in-depth review current research diagnostic value possible biomarkers for neutrophil-related diseases.
Language: Английский
Citations
18
Environmental Pollution, Journal Year: 2024, Volume and Issue: 359, P. 124742 - 124742
Published: Aug. 15, 2024
Language: Английский
Citations
8