The effect of model structure and data availability on Usutu virus dynamics at three biological scales
Royal Society Open Science,
Год журнала:
2024,
Номер
11(2)
Опубликована: Фев. 1, 2024
Understanding
the
epidemiology
of
emerging
pathogens,
such
as
Usutu
virus
(USUV)
infections,
requires
systems
investigation
at
each
scale
involved
in
host-virus
transmission
cycle,
from
individual
bird
to
bird-to-vector
transmissions,
and
USUV
incidence
vector
populations.
For
new
pathogens
field
data
are
sparse,
predictions
can
be
aided
by
use
laboratory-type
inoculation
experiments
combined
with
dynamical
mathematical
modelling.
In
this
study,
we
investigated
dynamics
two
strains
constructing
models
for
within-host
scale,
vector-borne
epidemiological
scale.
We
used
infectious
per
cent
mosquito
infection
predict
birds
mosquitoes.
addressed
dependence
on
model
structure,
uncertainty
experimental
design.
found
that
one
change
predicted
results
another
proposed
Язык: Английский
Identifiability investigation of within-host models of acute virus infection
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 10, 2024
Abstract
Uncertainty
in
parameter
estimates
from
fitting
within-host
models
to
empirical
data
limits
the
model’s
ability
uncover
mechanisms
of
infection,
disease
progression,
and
guide
pharmaceutical
interventions.
Understanding
effect
model
structure
availability
on
predictions
is
important
for
informing
development
experimental
design.
To
address
sources
uncertainty
estimation,
we
use
four
mathematical
influenza
A
infection
with
increased
degrees
biological
realism.
We
test
each
reveal
its
parameters
presence
unlimited
by
performing
structural
identifiability
analyses.
then
refine
results
predicting
practical
under
daily
virus
titers
alone
or
together
adaptive
immune
cell
data.
Using
these
approaches,
present
insight
into
estimation
provide
guidelines
types
assumptions,
optimal
design,
information
needed
improved
predictions.
Author
summary
Within-host
infections
fitted
have
our
understanding
allowed
us
Given
their
predictive
power,
it
essential
that
properly
estimation.
Here,
focus
unknown
parameters.
questions,
analysis.
insights
estimations
Язык: Английский
Assessing the role of model choice in parameter identifiability of cancer treatment efficacy
Frontiers in Applied Mathematics and Statistics,
Год журнала:
2025,
Номер
11
Опубликована: Март 24, 2025
Several
mathematical
models
are
commonly
used
to
describe
cancer
growth
dynamics.
Fitting
of
these
experimental
data
has
not
yet
determined
which
particular
model
best
describes
growth.
Unfortunately,
choice
is
known
drastically
alter
the
predictions
both
future
tumor
and
effectiveness
applied
treatment.
Since
there
growing
interest
in
using
help
predict
chemotherapy,
we
need
determine
if
affects
estimates
chemotherapy
efficacy.
Here,
simulate
an
vitro
study
by
creating
synthetic
treatment
each
seven
fit
sets
other
(“wrong”)
models.
We
estimate
ε
max
(the
maximum
efficacy
drug)
IC
50
drug
concentration
at
half
effect
achieved)
effort
whether
use
incorrect
changes
parameters.
find
that
largely
weakly
practically
identifiable
no
matter
generate
or
data.
The
more
likely
be
identifiable,
but
sensitive
model,
showing
poor
identifiability
when
Bertalanffy
either
Язык: Английский
A novel within-host model of HIV and nutrition
Mathematical Biosciences & Engineering,
Год журнала:
2024,
Номер
21(4), С. 5577 - 5603
Опубликована: Янв. 1, 2024
<abstract><p>In
this
paper
we
develop
a
four
compartment
within-host
model
of
nutrition
and
HIV.
We
show
that
the
has
two
equilibria:
an
infection-free
equilibrium
infection
equilibrium.
The
free
is
locally
asymptotically
stable
when
basic
reproduction
number
$
\mathcal{R}_0
<
1
$,
unstable
>
$.
if
additional
condition
holds.
HIV
structured
to
reveal
its
parameters
from
observations
viral
load,
CD4
cell
count
total
protein
data.
then
estimate
for
these
3
data
sets.
have
also
studied
practical
identifiability
by
performing
Monte
Carlo
simulations,
found
rate
clearance
virus
immunoglobulins
practically
unidentifiable,
rest
are
only
weakly
identifiable
given
experimental
Furthermore,
how
frequency
impacts
parameters.</p></abstract>
Язык: Английский
Incorporating Intracellular Processes in Virus Dynamics Models
Microorganisms,
Год журнала:
2024,
Номер
12(5), С. 900 - 900
Опубликована: Апрель 30, 2024
In-host
models
have
been
essential
for
understanding
the
dynamics
of
virus
infection
inside
an
infected
individual.
When
used
together
with
biological
data,
they
provide
insight
into
viral
life
cycle,
intracellular
and
cellular
virus–host
interactions,
role,
efficacy,
mode
action
therapeutics.
In
this
review,
we
present
standard
model
highlight
situations
where
added
complexity
accounting
processes
is
needed.
We
several
examples
from
acute
chronic
infections
such
inclusion
in
explicit
implicit
manner
has
led
to
improvement
parameter
estimates,
unification
conclusions,
guidance
targeted
therapeutics,
crossover
among
systems.
also
discuss
trade-offs
between
realism
predictive
power
need
increased
data
collection
at
finer
scale
resolution
better
validate
complex
models.
Язык: Английский
Validation of a Multi-Strain HIV Within-Host Model with AIDS Clinical Studies
Mathematics,
Год журнала:
2024,
Номер
12(16), С. 2583 - 2583
Опубликована: Авг. 21, 2024
We
used
a
previously
introduced
HIV
within-host
model
with
sensitive
and
resistant
strains
validated
it
two
data
sets.
The
first
set
is
from
clinical
study
that
investigated
multi-drug
treatments
measured
the
total
CD4+
cell
count
viral
load.
All
nine
patients
in
this
experienced
virologic
failure.
second
includes
unique
patient
who
was
treated
drug
for
whom
both
were
as
well
cells.
studied
structural
identifiability
of
respect
to
each
set.
With
set,
structurally
identifiable
when
production
rate
strain
fixed
distinct
strain.
always
identifiable.
fit
using
nonlinear
mixed
effect
modeling
Monolix
estimated
population-level
parameters.
inferred
average
time
emergence
844
days
after
treatment
starts.
found
out
all
parameters
except
mutation
practically
Язык: Английский
Usutu virus, an emerging arbovirus with One Health importance
Advances in virus research,
Год журнала:
2024,
Номер
unknown, С. 39 - 75
Опубликована: Янв. 1, 2024
Язык: Английский
A mathematical model for the role of vaccination and treatment in measles transmission in Turkey
Journal of Computational and Applied Mathematics,
Год журнала:
2024,
Номер
457, С. 116308 - 116308
Опубликована: Окт. 11, 2024
Язык: Английский
Identifiability investigation of within-host models of acute virus infection
Mathematical Biosciences & Engineering,
Год журнала:
2024,
Номер
21(10), С. 7394 - 7420
Опубликована: Янв. 1, 2024
<p>Uncertainty
in
parameter
estimates
from
fitting
within-host
models
to
empirical
data
limits
the
model's
ability
uncover
mechanisms
of
infection,
disease
progression,
and
guide
pharmaceutical
interventions.
Understanding
effect
model
structure
availability
on
predictions
is
important
for
informing
development
experimental
design.
To
address
sources
uncertainty
estimation,
we
used
four
mathematical
influenza
A
infection
with
increased
degrees
biological
realism.
We
tested
each
reveal
its
parameters
presence
unlimited
by
performing
structural
identifiability
analyses.
then
refined
results
predicting
practical
under
daily
virus
titers
alone
or
together
adaptive
immune
cell
data.
Using
these
approaches,
presented
insight
into
estimation
provided
guidelines
types
assumptions,
optimal
design,
information
needed
improved
predictions.</p>
Язык: Английский