Marine transmissible cancer navigates urbanized waters, threatening spillover
Proceedings of the Royal Society B Biological Sciences,
Год журнала:
2024,
Номер
291(2017)
Опубликована: Фев. 21, 2024
Inter-individual
transmission
of
cancer
cells
represents
a
unique
form
microparasites
increasingly
reported
in
marine
bivalves.
In
this
study,
we
sought
to
understand
the
ecology
propagation
Mytilus
trossulus
Bivalve
Transmissible
Neoplasia
2
(MtrBTN2),
transmissible
affecting
four
mussel
species
worldwide.
We
investigated
prevalence
MtrBTN2
mosaic
hybrid
zone
M.
edulis
and
galloprovincialis
along
French
Atlantic
coast,
sampling
contrasting
natural
anthropogenic
habitats.
observed
similar
both
species,
probably
due
spatial
proximity
two
region.
Our
results
showed
that
ports
had
higher
MtrBTN2,
with
possible
hotspot
at
shuttle
landing
dock.
No
was
found
beds
except
for
sites
close
hotspot,
suggesting
spillover.
Ports
may
provide
favourable
conditions
such
as
high
density,
stressful
conditions,
sheltered
confined
shores
or
buffered
temperatures.
Ships
also
spread
disease
through
biofouling.
suggest
serve
epidemiological
hubs,
maritime
routes
providing
artificial
gateways
propagation.
This
highlights
importance
preventing
biofouling
on
docks
ship
hulls
limit
pathogens
hosted
by
fouling
species.
Язык: Английский
Epidemiological insight into disseminated neoplasia in Mytilus chilensis from southern Chile
Journal of Invertebrate Pathology,
Год журнала:
2025,
Номер
209, С. 108273 - 108273
Опубликована: Янв. 20, 2025
Язык: Английский
De novo evolution of transmissible tumours in hydra
Proceedings of the Royal Society B Biological Sciences,
Год журнала:
2024,
Номер
291(2031)
Опубликована: Сен. 1, 2024
While
most
cancers
are
not
transmissible,
there
rare
cases
where
cancer
cells
can
spread
between
individuals
and
even
across
species,
leading
to
epidemics.
Despite
their
significance,
the
origins
of
such
remain
elusive
due
late
detection
in
host
populations.
Using
Hydra
oligactis
,
which
exhibits
spontaneous
tumour
development
that
some
strains
became
vertically
transmitted,
this
study
presents
first
experimental
observation
evolution
a
transmissible
tumour.
Specifically,
we
assessed
initial
vertical
transmission
rate
tumours
explored
potential
for
optimizing
through
artificial
selection.
One
hydra
strains,
evolved
over
five
generations,
was
characterized
by
analysis
cell
type
bacteriome,
assessment
life-history
traits.
Our
findings
indicate
be
immediate
enhanced
The
resulting
overproliferation
large
interstitial
stem
associated
with
specific
bacteriome.
Furthermore,
despite
only
generations
transmission,
these
induced
notable
alterations
traits,
hinting
at
compensatory
response.
This
work,
therefore,
makes
contribution
understanding
conditions
emergence
short-term
consequences
host.
Язык: Английский
De novoevolution of transmissible tumors in Hydra
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 14, 2024
Abstract
While
most
cancers
are
not
transmissible,
there
rare
cases
where
cancer
cells
have
acquired
the
ability
to
spread
vertically
or
horizontally
other
individuals,
and
sometimes
species,
causing
epidemics
in
their
hosts.
However,
as
these
transmissible
usually
detected
once
they
relatively
well
disseminated
host
populations,
conditions
associated
with
origin
remain
poorly
understood.
Using
freshwater
cnidarian
Hydra
oligactis
,
which
exhibits
spontaneous
tumor
development
that
some
strains
became
transmitted,
this
study
presents
first
experimental
observation
of
evolution
a
tumor.
Specifically,
we
assessed
initial
vertical
transmission
rate
tumors
explored
potential
for
optimizing
through
artificial
selection.
One
hydra
strains,
evolved
over
five
generations,
was
characterized
by
analysis
cell
type
microbiome,
assessment
life-history
traits.
Our
findings
indicate
can
be
immediate
enhanced
The
resulting
overproliferation
large
interstitial
stem
and,
contrast
on
Hydra,
specific
microbiome.
Furthermore,
although
has
only
been
established
5
it
sufficient
alter
traits
host,
suggesting
compensatory
response.
This
work,
therefore,
makes
contribution
understanding
emergence
short-term
consequences
host.
Язык: Английский
The widespread vulnerability of Hydra oligactis to tumourigenesis confirms its value as a model for studying the effects of tumoural processes on the ecology and evolution of species
The Science of The Total Environment,
Год журнала:
2024,
Номер
951, С. 175785 - 175785
Опубликована: Авг. 24, 2024
Tumoural
processes,
ubiquitous
phenomena
in
multicellular
organisms,
influence
evolutionary
trajectories
of
all
species.
To
gain
a
holistic
understanding
their
impact
on
species'
biology,
suitable
laboratory
models
are
required.
Such
characterised
by
widespread
availability,
ease
cultivation,
and
reproducible
tumour
induction.
It
is
especially
important
to
explore,
through
experimental
approaches,
how
tumoural
processes
alter
ecosystem
functioning.
The
cnidarian
Hydra
oligactis
currently
emerging
as
promising
model
due
its
development
both
transmissible
non-transmissible
tumours
the
wide
breadth
experiments
that
can
be
conducted
with
this
species
(at
individual,
population,
mechanistic,
levels).
However,
hydras
are,
so
far,
only
documented
Europe,
it
not
clear
if
phenomenon
local
or
widespread.
In
study
we
demonstrate
Australian
from
two
independent
river
networks
develop
consisting
interstitial
stem
cells
display
phenotypic
alterations
(supernumerary
tentacles)
akin
European
counterparts.
This
finding
confirms
value
for
ecological
research
host-tumour
interactions.
•
Tumoral
biology
dynamics
There
need
good
context
increased
oncogenic
pressures
We
show
has
geographical
vulnerabilities
tumorigenesis
thus
great
effect
functioning
discuss
implications
using
future
comparative
studies
Язык: Английский
Novel PCR assay for the identification of two transmissible cancers in Cerastoderma edule
Journal of Invertebrate Pathology,
Год журнала:
2024,
Номер
207, С. 108232 - 108232
Опубликована: Ноя. 1, 2024
Transmissible
cancers
are
a
rare
phenomenon
in
which
cancer
cells
passed
between
individuals,
leading
to
the
development
of
neoplasia
host
organism.
have
been
identified
three
independent
clonal
lineages
mammals
and
eight
different
bivalves.
This
study
focused
on
multiplex
PCR
assay
for
detection
two
types
bivalve
transmissible
neoplasias
(BTN)
cockles
Cerastoderma
edule
(CedBTN1
CedBTN2).
The
diagnostic
sensitivity
(Se)
specificity
(Sp)
new
hemolymph
samples
were
assessed
using
maximum
likelihood
estimation
88
compared
diagnoses
obtained
by
histology
confirmed
with
genomic
analyses.
results
showed
Se
100
%
Sp
98.1
CedBTN1,
CedBTN2.
analytical
tested
DNA
extractions
from
infected
non-infected
C.
other
bivalves
affected
BTN.
demonstrated
high
specificity,
detecting
down
0.4
circulating
CedBTN1
at
concentration
0.05
ng/µL
sample
cockle
85.7
cells.
was
type-specific
CedBTN
capable
both
simultaneously.
Overall,
this
is
reliable
tool
will
facilitate
diagnosis
monitoring
disease.
Язык: Английский
Adaptive alien genes are maintained amid a vanishing introgression footprint in a sea squirt
Evolution Letters,
Год журнала:
2024,
Номер
8(4), С. 600 - 609
Опубликована: Апрель 27, 2024
Abstract
Human
transport
of
species
across
oceans
disrupts
natural
dispersal
barriers
and
facilitates
hybridization
between
previously
allopatric
species.
The
recent
introduction
the
North
Pacific
sea
squirt,
Ciona
robusta,
into
native
range
Atlantic
intestinalis,
is
a
good
example
this
outcome.
Recent
studies
have
revealed
an
adaptive
introgression
in
single
chromosomal
region
from
introduced
Here,
we
monitored
over
time,
examining
both
frequency
alleles
at
core
hitchhiking
footprint
shoulders
island
by
studying
thousand
spp.
individuals
collected
22
ports
contact
zone,
14
which
were
sampled
20
generations
apart.
For
that
purpose,
developed
KASP
multiplex
genotyping
approach,
proved
effective
identifying
native,
nonindigenous
hybrid
detecting
introgressed
haplotypes.
We
found
no
early
generation
hybrids
entire
sample,
field
observations
suggest
decline
At
sweep,
where
C.
robusta
highest
local
adaptation
genes
must
be,
observed
stable
frequencies
alien
space
time.
In
contrast,
erosion
ancestry
tracts
flanking
on
edges
core,
consistent
with
second
phase
sweep
purge
hitchhiked
incompatible
mutations.
hypothesize
may
modified
competition
relationships
invasive
human-altered
environments.
Язык: Английский
Approaches and methods to study wildlife cancer
Journal of Animal Ecology,
Год журнала:
2024,
Номер
93(10), С. 1410 - 1428
Опубликована: Авг. 27, 2024
Abstract
The
last
few
years
have
seen
a
surge
of
interest
from
field
ecologists
and
evolutionary
biologists
to
study
neoplasia
cancer
in
wildlife.
This
contributes
the
One
Health
Approach,
which
investigates
health
issues
at
intersection
people,
wild
domestic
animals,
together
with
their
changing
environments.
Nonetheless,
emerging
wildlife
is
currently
constrained
by
methodological
limitations
detecting
using
non‐invasive
sampling.
In
addition,
suspected
differential
susceptibility
resistance
species
often
make
choice
unique
model
difficult
for
biologists.
Here,
we
provide
an
overview
importance
pursuing
non‐model
organisms
review
available
methods
detect,
measure
quantify
wild,
as
well
be
overcome
develop
novel
approaches
inspired
diagnostic
techniques
used
human
medicine.
methodology
propose
here
will
help
understand
hopefully
fight
this
major
disease
generating
general
knowledge
about
cancer,
variation
its
rates,
tumour‐suppressor
mechanisms
across
link
life
history
physiological
characters.
Moreover,
expected
key
information
wildlife,
top
priority
due
accelerated
anthropogenic
change
past
decades
that
might
favour
progression
populations.
Язык: Английский
Oncogenic processes: a neglected parameter in the evolutionary ecology of animals
Comptes Rendus Biologies,
Год журнала:
2024,
Номер
347(G1), С. 137 - 157
Опубликована: Ноя. 7, 2024
Cancer
is
a
biological
process
that
emerged
at
the
end
of
Precambrian
era
with
rise
multicellular
organisms.
Traditionally,
cancer
has
been
viewed
primarily
as
disease
relevant
to
human
and
domesticated
animal
health,
attracting
attention
mainly
from
oncologists.
In
recent
years,
however,
community
ecologists
evolutionary
biologists
recognized
pivotal
role
cancer-related
issues
in
paths
various
species,
influencing
multiple
facets
their
biology.
It
become
evident
overlooking
these
untenable
for
comprehensive
understanding
species
evolution
ecosystem
functioning.
this
article,
we
highlight
some
significant
advancements
field,
also
underscoring
pressing
need
consider
reciprocal
interactions
not
only
between
cells
hosts
but
all
entities
comprising
holobiont.
This
reflection
gains
particular
relevance
ecosystems
face
increasing
pollution
mutagenic
substances,
resulting
resurgence
cases
wildlife.
Le
est
un
processus
biologique
qui
émergé
à
la
fin
de
l'ère
précambrienne
avec
l'apparition
des
organismes
multicellulaires.
Traditionnellement,
le
été
principalement
perçu
comme
une
maladie
touchant
santé
humaine
et
celle
animaux
domestiques,
attirant
l'attention
oncologues.
Cependant,
ces
dernières
années,
communauté
écologistes
biologistes
évolutionnistes
reconnu
rôle
central
questions
liées
au
dans
les
trajectoires
évolutives
diverses
espèces,
influençant
multiples
aspects
leur
biologie.
Il
devenu
évident
que
négliger
enjeux
intenable
pour
compréhension
exhaustive
l'évolution
espèces
du
fonctionnement
écosystèmes.
Dans
cet
nous
mettons
en
lumière
certaines
avancées
significatives
ce
domaine,
soulignant
également
nécessité
pressante
considérer
réciproques
non
seulement
entre
cellules
cancéreuses
leurs
hôtes,
mais
aussi
toutes
entités
constituant
l'holobionte.
Cette
réflexion
prend
pertinence
particulière
alors
écosystèmes
sont
confrontés
croissante
par
substances
mutagènes,
entraînant
résurgence
cas
faune
sauvage.