The link between space and time along the human cortical hierarchy

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 16, 2024

Abstract In humans, very few studies have directly tested the link between neural coding of time and space. Here we combined ultra-high field functional magnetic resonance imaging with neuronal-based modeling to investigate how where processing representation a visual stimulus duration is linked that its spatial location. Results show transition in response duration: from monotonic spatially-dependent early cortex, unimodal spatially-invariant frontal cortex. This begins extrastriate areas V3AB, it fully displays intraparietal sulcus (IPS), both responses are present neuronal populations selective either space, or both. IPS, space topographies specific relationship, although along cortical hierarchy maps compared ones smaller size, less clustered more variable across participants. These results help identify mechanisms through which humans perceive object location precisely characterize processing, highlighting importance space-time interactions shaping brain responses.

Язык: Английский

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In vivo cartography of state-dependent signal flow hierarchy in the human cerebral cortex

Опубликована: Окт. 21, 2024

Understanding the principle of information flow across distributed brain networks is paramount importance in neuroscience. Here, we introduce a novel neuroimaging framework, leveraging integrated effective connectivity (iEC) and unconstrained signal mapping for data-driven discovery human cerebral functional hierarchy. Simulation empirical validation demonstrated high fidelity iEC recovering connectome directionality its potential relationship with histologically defined feedforward feedback pathways. Notably, iEC-derived hierarchy displayed monotonously increasing level along axis where sensorimotor, association, paralimbic areas are sequentially ordered – pattern supported by Structural Model laminar connectivity. This was further to flexibly reorganize according states, flattening during an externally oriented condition, evidenced reduced slope hierarchy, steepening internally focused reflecting heightened engagement interoceptive regions. Our study highlights unique role macroscale directed uncovering neurobiologically grounded, state-dependent

Язык: Английский

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Neural correlates of audiovisual integration in schizophrenia – an ERP study

Frontiers in Psychiatry, Год журнала: 2024, Номер 15

Опубликована: Дек. 10, 2024

Multisensory integration (MSI) enhances perception by combining information from different sensory modalities. In schizophrenia, individuals often exhibit impaired audiovisual processing, resulting in broader temporal binding windows (TBWs) which appear to be associated with symptom severity. Since the underlying mechanisms of these aberrations are not yet fully understood, present study aims investigate multisensory processing schizophrenia more detail.

Язык: Английский

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Inferring community architectures of multisensory pathways inDrosophilavia unsupervised network embedding

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 22, 2024

Abstract Understanding the complex architecture and functions of neural circuits is central to unraveling mechanisms multisensory integration. In this study, we analyzed structural properties Drosophila adult brain infer community structures within pathways. We adopt a network embedding method developed by ourselves, Bidirectional Heterogeneous Graph Neural Network with Random Teleport (BHGNN-RT), designed generate vector representations neurons in directed, heterogeneous connectome. This approach takes advantage both connectivity heterogeneity features, enabling effective clustering revealing hierarchical architectures olfactory broader systems. applied BHGNN-RT fly connectome examine connectivity-based organization major neuronal classes along pathways, distinct groups unique patterns antennal lobe, lateral horn, mushroom body, other regions. Further analysis showed how different contribute integration sensory information also investigated bilateral symmetry pathway, shedding light on signals are processed ipsilateral contralateral connections ensure robust perception. Our findings demonstrate utility graph representation learning analyzing The insights gained from provide deeper understanding comprehension underlying

Язык: Английский

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The neural link between stimulus duration and spatial location in the human visual hierarchy

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Дек. 27, 2024

Integrating spatial and temporal information is essential for our sensory experience. While psychophysical evidence suggests dependencies in duration perception, few studies have directly tested the neural link between processing. Using ultra-high-field functional MRI neuronal-based modeling, we investigated how where processing representation of a visual stimulus linked to that its location. Our results show transition coding: from monotonic spatially-dependent early cortex unimodal spatially-invariant frontal cortex. Along dorsal stream, particularly intraparietal sulcus (IPS), neuronal populations common selective responses both information. In IPS, topographic organizations are also linked, although maps smaller, less clustered, more variable across participants. These findings help identify mechanisms underlying human perception characterize time space processing, highlighting importance their interactions shaping brain responses. Common organizational principles not fully understood. This study shows coding brief events transforms along cortical hierarchy, interact through representations.

Язык: Английский

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