The neural link between stimulus duration and spatial location in the human visual hierarchy DOI Creative Commons
Valeria Centanino, Gianfranco Fortunato, Domenica Bueti

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 27, 2024

Integrating spatial and temporal information is essential for our sensory experience. While psychophysical evidence suggests dependencies in duration perception, few studies have directly tested the neural link between processing. Using ultra-high-field functional MRI neuronal-based modeling, we investigated how where processing representation of a visual stimulus linked to that its location. Our results show transition coding: from monotonic spatially-dependent early cortex unimodal spatially-invariant frontal cortex. Along dorsal stream, particularly intraparietal sulcus (IPS), neuronal populations common selective responses both information. In IPS, topographic organizations are also linked, although maps smaller, less clustered, more variable across participants. These findings help identify mechanisms underlying human perception characterize time space processing, highlighting importance their interactions shaping brain responses. Common organizational principles not fully understood. This study shows coding brief events transforms along cortical hierarchy, interact through representations.

Language: Английский

Neural correlates of audiovisual integration in schizophrenia – an ERP study DOI Creative Commons
Anna Borgolte, Christopher Sinke,

L. Michalke

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 10, 2024

Multisensory integration (MSI) enhances perception by combining information from different sensory modalities. In schizophrenia, individuals often exhibit impaired audiovisual processing, resulting in broader temporal binding windows (TBWs) which appear to be associated with symptom severity. Since the underlying mechanisms of these aberrations are not yet fully understood, present study aims investigate multisensory processing schizophrenia more detail.

Language: Английский

Citations

0
Inferring community architectures of multisensory pathways inDrosophilavia unsupervised network embedding DOI Creative Commons
Xiyang Sun, Fumiyasu Komaki

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 22, 2024

Abstract Understanding the complex architecture and functions of neural circuits is central to unraveling mechanisms multisensory integration. In this study, we analyzed structural properties Drosophila adult brain infer community structures within pathways. We adopt a network embedding method developed by ourselves, Bidirectional Heterogeneous Graph Neural Network with Random Teleport (BHGNN-RT), designed generate vector representations neurons in directed, heterogeneous connectome. This approach takes advantage both connectivity heterogeneity features, enabling effective clustering revealing hierarchical architectures olfactory broader systems. applied BHGNN-RT fly connectome examine connectivity-based organization major neuronal classes along pathways, distinct groups unique patterns antennal lobe, lateral horn, mushroom body, other regions. Further analysis showed how different contribute integration sensory information also investigated bilateral symmetry pathway, shedding light on signals are processed ipsilateral contralateral connections ensure robust perception. Our findings demonstrate utility graph representation learning analyzing The insights gained from provide deeper understanding comprehension underlying

Language: Английский

Citations

0
Low vision aids and age are associated with Müller-Lyer illusion in congenital visually impaired children DOI Creative Commons
Na Lin,

Bichi Chen,

Maoyuan Yang

et al.

Frontiers in Psychology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 24, 2023

Background The correlation between visual impairment and Müller-Lyer illusion is not yet elucidated. This study aimed to explore the connection status, age, intensity of in congenitally visually impaired healthy children aged 4–17 years. Additionally, developmental trends were compared. Methods cross-sectional included 125 (age: 10.59 ± 4.05 years), among them, 53 had utilized low vision aids (LVAs) 133 controls 11.33 3.39 years). participants presented with stimuli via binocular engaged a two-alternative forced choice task quantify intensity. Pertinent factors including gender, residence, distant best-corrected acuity LVAs usage history, assessed. Results group exhibited significantly elevated compared (9.74 2.89% vs. 5.42 3.81%, p < 0.001), who used lower those (9.13 3.00% 10.19 2.74%, = 0.043). Multivariate generalized estimation equations revealed that [odds ratio (OR) 2.75, 0.001] age (OR 0.60, 0.001) associated all participants, while history 0.49, 0.045) 0.61, negatively correlated group. A negative was found years subgroups ( Y −0.54X + 15.06, R 2 0.56), −0.49X 15.24, 0.51), −0.50X 11.18, 0.21); -values 0.001. Conclusion Children afflicted congenital heightened normal counterparts, experience could reduce this higher trajectory declined consistently across three groups. abnormal experiences during early-life may adversely affect integration children, facilitate functional development.

Language: Английский

Citations

1
In vivo cartography of state-dependent signal flow hierarchy in the human cerebral cortex DOI
Seok‐Jun Hong, Young Lyun Oh,

Yejin Ann

et al.

Published: Oct. 21, 2024

Abstract Understanding the principle of information flow across distributed brain networks is paramount importance in neuroscience. Here, we introduce a novel neuroimaging framework, leveraging integrated effective connectivity (iEC) and unconstrained signal mapping for data-driven discovery human cerebral functional hierarchy. Simulation empirical validation demonstrated high fidelity iEC recovering connectome directionality its potential relationship with histologically defined feedforward feedback pathways. Notably, iEC-derived hierarchy displayed monotonously increasing level along axis where sensorimotor, association, paralimbic areas are sequentially ordered – pattern supported by Structural Model laminar connectivity. This was further to flexibly reorganize according states, flattening during an externally oriented condition, evidenced reduced slope hierarchy, steepening internally focused reflecting heightened engagement interoceptive regions. Our study highlights unique role macroscale directed uncovering neurobiologically grounded, state-dependent

Language: Английский

Citations

0
The neural link between stimulus duration and spatial location in the human visual hierarchy DOI Creative Commons
Valeria Centanino, Gianfranco Fortunato, Domenica Bueti

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 27, 2024

Integrating spatial and temporal information is essential for our sensory experience. While psychophysical evidence suggests dependencies in duration perception, few studies have directly tested the neural link between processing. Using ultra-high-field functional MRI neuronal-based modeling, we investigated how where processing representation of a visual stimulus linked to that its location. Our results show transition coding: from monotonic spatially-dependent early cortex unimodal spatially-invariant frontal cortex. Along dorsal stream, particularly intraparietal sulcus (IPS), neuronal populations common selective responses both information. In IPS, topographic organizations are also linked, although maps smaller, less clustered, more variable across participants. These findings help identify mechanisms underlying human perception characterize time space processing, highlighting importance their interactions shaping brain responses. Common organizational principles not fully understood. This study shows coding brief events transforms along cortical hierarchy, interact through representations.

Language: Английский

Citations

0