Evolutionary conservation and metabolic significance of autophagy in algae.
PubMed,
Год журнала:
2024,
Номер
379(1914), С. 20230368 - 20230368
Опубликована: Ноя. 18, 2024
Autophagy
is
a
highly
conserved
'self-digesting'
mechanism
used
in
eukaryotes
to
degrade
and
recycle
cellular
components
by
enclosing
them
double
membrane
compartment
delivering
lytic
organelles
(lysosomes
or
vacuoles).
Extensive
studies
plants
have
revealed
how
autophagy
intricately
linked
essential
aspects
of
metabolism
growth,
both
normal
stress
conditions,
including
organelle
homeostasis,
nutrient
recycling,
development,
responses
biotic
abiotic
stresses,
senescence
cell
death.
However,
knowledge
regarding
autophagic
processes
other
photosynthetic
organisms
remains
limited.
In
this
review,
we
attempt
summarize
the
current
understanding
algae
from
metabolic,
molecular
evolutionary
perspective.
We
focus
on
composition
conservation
machinery
discuss
role
metabolic
regulation,
homeostasis
adaptation
algae.
This
article
part
theme
issue
'The
evolution
plant
metabolism'.
Язык: Английский
Integrative Human Genetic and Cellular Analysis of the Pathophysiological Roles of AnxA2 in Alzheimer’s Disease
Antioxidants,
Год журнала:
2024,
Номер
13(10), С. 1274 - 1274
Опубликована: Окт. 21, 2024
Alzheimer's
disease
(AD)
is
an
intractable
and
progressive
neurodegenerative
disease.
Amyloid
beta
(Aβ)
aggregation
the
hallmark
of
AD.
Aβ
induces
neurotoxicity
through
a
variety
mechanisms,
including
interacting
with
membrane
receptors
to
alter
downstream
signaling,
damaging
cellular
or
organelle
membranes,
interfering
protein
degradation
synthesis,
inducing
excessive
immune-inflammatory
response,
all
which
lead
neuronal
death
other
pathological
changes
associated
In
this
study,
we
extracted
gene
expression
profiles
from
GSE5281
GSE97760
microarray
datasets
in
GEO
(Gene
Expression
Omnibus)
database,
as
well
Human
Gene
Database.
We
identified
differentially
expressed
genes
brain
tissues
AD
patients
healthy
persons.
Through
GO,
KEGG,
ROC
analyses,
annexin
A2
(AnxA2)
was
putative
target
gene.
Notably,
accumulating
evidence
suggests
that
intracellular
AnxA2
key
regulator
various
biological
processes,
endocytosis,
transmembrane
transport,
neuroinflammation,
apoptosis.
Thus,
conducted
series
cell
biology
experiments
explore
function
The
results
indicate
knockdown
primarily
affects
oxidative
phosphorylation,
cycle,
AD,
processing
endoplasmic
reticulum,
SNARE
interactions
vesicular
autophagy.
SH-SY5Y
cells
secreting
Aβ42,
exacerbated
Aβ42-induced
cytotoxicity,
death,
ROS
levels,
senescence,
altered
reduced
ATP
suggesting
its
critical
role
mitochondrial
maintenance.
also
inhibitory
effect
Aβ42
on
migration.
overexpression
inflammatory
response
induced
by
while
absence
increased
pro-inflammatory
decreased
anti-inflammatory
responses.
Furthermore,
facilitated
apoptosis
These
indicated
potential
pathophysiological
roles
Язык: Английский
Current and future perspectives for enhancing our understanding of the evolution of plant metabolism
Philosophical Transactions of the Royal Society B Biological Sciences,
Год журнала:
2024,
Номер
379(1914)
Опубликована: Сен. 29, 2024
The
special
issue
‘The
evolution
of
plant
metabolism’
has
brought
together
original
research,
reviews
and
opinions
that
cover
various
aspects
from
the
full
breath
metabolism
including
its
interaction
with
environment
other
species.
Here,
we
briefly
summarize
these
efforts
attempts
to
extract
a
consensus
opinion
best
manner
in
which
tackle
this
subject
both
now
future.
This
article
is
part
theme
metabolism’.
Язык: Английский