Gut Bacteroides species in health and disease

Gut Microbes, Год журнала: 2021, Номер 13(1)

Опубликована: Янв. 1, 2021

The functional diversity of the mammalian intestinal microbiome far exceeds that host organism, and microbial genes contribute substantially to well-being host. However, beneficial gut organisms can also be pathogenic when present in or other locations body. Among dominant bacteria are several species

Язык: Английский

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Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Июнь 25, 2022

Abstract Pseudomonas aeruginosa ( P. ) is a Gram-negative opportunistic pathogen that infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive pulmonary disorder (COPD), cancer, and severe infection requiring ventilation, such as COVID-19. also widely-used model bacterium for all biological areas. In addition to continued, intense efforts in understanding bacterial pathogenesis of including virulence factors (LPS, quorum sensing, two-component systems, 6 type secretion outer membrane vesicles (OMVs), CRISPR-Cas their regulation), rapid progress has been made further studying host-pathogen interaction, particularly host immune networks involving autophagy, inflammasome, non-coding RNAs, cGAS, etc . Furthermore, numerous technologic advances, bioinformatics, metabolomics, scRNA-seq, nanoparticles, drug screening, phage therapy, have used improve our defense. Nevertheless, much remains be uncovered about interactions between responses, mechanisms resistance by known or unannotated well mammalian cell signaling pathways. The widespread use antibiotics the slow development effective antimicrobials present daunting challenges necessitate new theoretical practical platforms screen develop mechanism-tested novel drugs treat intractable infections, especially those caused multi-drug strains. Benefited from advancing research tools technology, dissecting this pathogen’s feature entered into molecular mechanistic details dynamic holistic views. Herein, we comprehensively review discuss current status biophysical traits, behaviors, factors, invasive regulators, defense patterns against its infection, which point out directions future investigation add design and/or alternative therapeutics combat clinically significant pathogen.

Язык: Английский

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A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing

Nature, Год журнала: 2020, Номер 583(7817), С. 631 - 637

Опубликована: Июль 8, 2020

Язык: Английский

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Bacterial defences: mechanisms, evolution and antimicrobial resistance

Nature Reviews Microbiology, Год журнала: 2023, Номер 21(8), С. 519 - 534

Опубликована: Апрель 24, 2023

Язык: Английский

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Microbiome manipulation by a soil-borne fungal plant pathogen using effector proteins

Nature Plants, Год журнала: 2020, Номер 6(11), С. 1365 - 1374

Опубликована: Ноя. 2, 2020

Язык: Английский

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Mechanisms underlying gut microbiota–host interactions in insects

Journal of Experimental Biology, Год журнала: 2021, Номер 224(2)

Опубликована: Янв. 15, 2021

ABSTRACT Insects are the most diverse group of animals and colonize almost all environments on our planet. This diversity is reflected in structure function microbial communities inhabiting insect digestive system. As mammals, gut microbiota insects can have important symbiotic functions, complementing host nutrition, facilitating dietary breakdown or providing protection against pathogens. There an increasing number models that experimentally tractable, mechanistic studies microbiota–host interactions. In this Review, we will summarize recent findings advanced understanding molecular mechanisms underlying symbiosis between their microbiota. We open article with a general introduction to then turn towards discussion particular processes governing colonization environment as well beneficial roles mediated by The Review highlights that, although active field research implications for fundamental applied science, still early stage mechanisms. However, expanding capability culture microbiomes manipulate microbe–host interactions promises new insights from symbioses.

Язык: Английский

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Metabolic exchanges are ubiquitous in natural microbial communities

Nature Microbiology, Год журнала: 2023, Номер 8(12), С. 2244 - 2252

Опубликована: Ноя. 23, 2023

Язык: Английский

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Rhizosphere bacterial interactions and impact on plant health

Current Opinion in Microbiology, Год журнала: 2023, Номер 73, С. 102297 - 102297

Опубликована: Март 30, 2023

The rhizosphere is a chemically complex environment that harbors strikingly diverse microbial community. past few decades have seen rapid growth in the body of literature on plant–microbe–microbe interactions and plant health. Thus, aim this paper to review current knowledge (specifically bacteria) how these influence microbiomes impact This article discusses (i) recruits beneficial bacteria ii) competition between mechanisms/weapons employed bacteria–bacteria shapes microbiome turn affects heath. discussion mainly focuses interference competition, characterized by production specialized metabolites (antibacterial compounds) exploitative where bacterial strain restricts competitor's access nutrients such as through secretion siderophores could allude cooperation. Understanding mechanisms plant–bacteria provide insights into manipulate for improved agricultural outcomes.

Язык: Английский

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TypeVIsecretion system effector proteins: Effective weapons for bacterial competitiveness

Cellular Microbiology, Год журнала: 2020, Номер 22(9)

Опубликована: Июнь 27, 2020

The Type VI secretion system (T6SS) is a protein translocation nanomachine widespread among Gram-negative bacteria and used as means to deliver effectors directly into target bacterial or eukaryotic cells. These have wide variety of functions within cells that ultimately help the secreting cell gain competitive fitness advantage. Here, we discuss different ways in which these can be delivered by T6SS diverse mechanisms they exert their noxious action upon recipient We also highlight existence roles for beyond simply killing neighbouring

Язык: Английский

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Structure and Activity of the Type VI Secretion System

Microbiology Spectrum, Год журнала: 2019, Номер 7(4)

Опубликована: Июль 12, 2019

ABSTRACT The type VI secretion system (T6SS) is a multiprotein machine that uses spring-like mechanism to inject effectors into target cells. injection apparatus composed of baseplate on which built contractile tail tube/sheath complex. inner tube, topped by the spike complex, propelled outside cell contraction sheath. anchored envelope and oriented towards exterior trans-envelope Effectors delivered T6SS are loaded within tube or complex can prokaryotic and/or eukaryotic Here we summarize structure, assembly, action T6SS. We also review function their mode recruitment delivery.

Язык: Английский

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