Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 2, 2023
Abstract
Aging
clocks
have
provided
one
of
the
most
significant
recent
breakthroughs
in
biology
aging.
Such
allow
determination
chronological
and
increasingly
also
biological
age,
which
is
a
prerequisite
for
assessing
effectiveness
interventions
aging
process
preventive
treatments
age-related
diseases.
The
advanced
are
based
on
age-dependent
changes
DNA
methylation
pattern.
reproducibility
such
over
life
course
has
reinvigorated
debate
whether
programmed
underlies
A
process,
however,
incompatible
with
evolutionary
theory
occurs
as
consequence
vanishing
force
selective
pressure
post-reproduction
no
fitness
benefit
by
immortality
soma.
In
fact,
stochastic
events
been
observed
to
occur
during
process.
Here,
we
test
could
be
built
entirely
variation.
We
find
that
accumulating
variation
sufficient
accurately
predict
age.
Moreover,
current
compatible
random
alterations
or
transcriptomic
patterns.
Our
analysis
unifies
clock
measure
predicts
any
set
data
ground
state
at
age
zero
used
building
accurate
clocks.
Human Genetics,
Год журнала:
2023,
Номер
142(8), С. 1293 - 1302
Опубликована: Апрель 1, 2023
Aging
is
a
progressive
multifaceted
functional
decline
of
biological
system.
Chronic
age-related
conditions
such
as
neurodegenerative
diseases
are
leading
causes
death
worldwide,
and
they
becoming
pressing
problem
for
our
society.
To
address
this
global
challenge,
there
need
novel,
safe,
effective
rejuvenation
therapies
aimed
at
reversing
phenotypes
improving
human
health.
With
gene
expression
being
key
determinant
cell
identity
function,
in
light
recent
studies
reporting
effects
through
genetic
perturbations,
we
propose
an
age
reversal
strategy
focused
on
reprogramming
the
transcriptome
to
youthful
state.
end,
suggest
using
transcriptomic
data
from
primary
cells
predict
targets
develop
high-throughput
aging
assays,
which
can
be
used
large
perturbation
screens.
We
neural
particularly
relevant
due
substantial
impact
neurodegeneration
frailty.
Of
all
types
brain,
argue
that
glutamatergic
neurons,
neuronal
stem
cells,
oligodendrocytes
represent
most
impactful
tractable
targets.
Lastly,
provide
experimental
designs
anti-aging
screens
will
likely
enable
development
therapies,
hold
promise
dramatically
Complexity
is
a
fundamental
feature
of
biological
systems.
Omics
techniques
like
lipidomics
can
simultaneously
quantify
many
thousands
molecules,
thereby
directly
capturing
the
underlying
complexity.
However,
this
approach
transfers
original
complexity
to
resulting
datasets,
posing
challenges
in
data
reduction
and
analysis.
Aging
prime
example
process
that
exhibits
complex
behaviour
across
multiple
scales
organisation.
The
aging
characterised
by
slow,
cumulative
detrimental
changes
are
driven
intrinsic
stochasticity
mediated
through
non-linear
interactions
feedback
within
between
these
levels
organization
(ranging
from
metabolites,
macromolecules,
organelles
cells
tissue
organs).
Only
collectively
over
long
timeframes
do
manifest
as
exponential
increases
morbidity
mortality
define
aging,
making
problem
more
difficult
study
than
aetiologies
specific
diseases.
But
aging's
time
dependence
also
be
exploited
extract
key
insights
into
its
biology.
Here
we
explore
idea
using
on
lipid
composition
lifespan
an
organism
construct
test
LipidClock
predict
age
nematode
ABSTRACT
During
aging,
animals
experience
a
decline
in
proteostasis
activity,
including
loss
of
stress-response
activation,
culminating
the
accumulation
misfolded
proteins
and
toxic
aggregates,
which
are
causal
onset
some
chronic
diseases.
Finding
genetic
pharmaceutical
treatments
that
can
increase
organismal
lengthen
life
is
an
ongoing
goal
current
research.
The
regulation
stress
responses
by
cell
non-autonomous
mechanisms
appears
to
be
potent
way
impact
healthspan.
In
this
Review,
we
cover
recent
findings
intersection
with
special
focus
on
articles
preprints
published
between
November
2021
October
2022.
A
significant
number
papers
during
time
increased
our
understanding
how
cells
communicate
each
other
proteotoxic
stress.
Finally,
also
draw
attention
emerging
datasets
explored
generate
new
hypotheses
explain
age-related
collapse.
The Journals of Gerontology Series A,
Год журнала:
2024,
Номер
79(10)
Опубликована: Янв. 11, 2024
Abstract
Widespread
interest
in
nondestructive
biomarkers
of
aging
has
led
to
a
multitude
biological
ages
that
each
proffers
“true”
health-adjusted
individual
age.
Although
measure
provides
salient
information
on
the
process,
they
are
univariate,
contrast
“hallmark”
and
“pillar”
theories
aging,
which
explicitly
multidimensional,
multicausal,
multiscale.
Fortunately,
multiple
can
be
systematically
combined
into
multidimensional
network
representation.
The
interaction
between
these
permits
analysis
effects
as
well
quantification
causal
influences
during
both
natural
and,
potentially,
after
anti-aging
intervention.
behavior
system
whole
then
explored
using
dynamical
stability
analysis,
identifies
new,
efficient
quantify
long-term
resilience
scores
timescale
measurements
(years).
We
demonstrate
this
approach
set
8
from
longitudinal
Swedish
Adoption/Twin
Study
Aging
(SATSA).
After
extracting
an
ages,
we
observed
physiological
age,
proxy
for
cardiometabolic
health,
serves
central
node
network,
implicating
it
key
vulnerability
slow,
age-related
decline.
furthermore
show
while
is
stable,
there
weakly
stable
direction
along
recovery
slow—on
human
lifespan.
This
slow
biomarker,
correlates
strongly
with
chronological
age
predicts
decline
health—suggesting
estimates
important
driver
changes.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2022,
Номер
unknown
Опубликована: Авг. 4, 2022
Abstract
Recent
studies
suggest
the
existence
of
a
natural
rejuvenation
event
during
early
embryonic
development
mice,
followed
by
epigenetic
aging.
Here,
profiling
DNA
methylation
in
African
clawed
frog,
Xenopus
laevis
,
we
found
that
entropy
basepoint
maps
to
gastrulation
stage
embryogenesis
and
corresponds
rapid
increase
embryo
transcript
abundance.
We
further
developed
frog
aging
clock,
revealing
this
species
epigenetically
ages.
Application
clock
developmental
stages
identified
decrease
age
embryogenesis,
with
minimal
reached
around
gastrulation.
By
examining
individual
trajectories
6,457
embryos,
is
also
accompanied
higher
incidence
disrupted
development.
Taken
together,
our
data
point
as
critical
for
rejuvenation,
characterized
lowest
age,
increased
mortality,
nadir
abundance,
defining
ground
zero
where
ends
process
begins.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 22, 2023
Background
Aging
involves
intricate
epigenetic
changes,
with
histone
modifications
playing
a
pivotal
role
in
dynamically
regulating
gene
expression.
Our
research
comprehensively
analyzes
seven
key
across
various
tissues
to
understand
their
behavior
during
human
aging
and
formulate
age
prediction
models.
Results
These
histone-centric
models
exhibit
remarkable
accuracy
resilience
against
experimental
artificial
noise.
They
showcase
comparable
efficacy
when
compared
DNA
methylation
predictors
through
simulation
experiments.
Intriguingly,
our
set
enrichment
analysis
pinpoints
vital
developmental
pathways
crucial
for
prediction.
Unlike
predictors,
genes
previously
recognized
animal
studies
as
integral
are
amongst
the
most
important
features
of
We
also
introduce
pan-histone-mark,
pan-tissue
predictor
that
operates
multiple
marks,
reinforcing
age-related
markers
not
restricted
particular
modifications.
Conclusion
findings
underscore
potential
marks
crafting
robust
shed
light
on
tapestry
alterations
aging.
Open Access Journal of Gerontology & Geriatric Medicine,
Год журнала:
2023,
Номер
7(2)
Опубликована: Март 31, 2023
A
brief
assessment
of
the
current
state
use
Hallmarks
aging
is
given
in
article.
It
noted
that
biological
clock
based
on
registration
DNA
methylation
process
only
a
statistical
indicator
and
has
no
direct
connection
to
known
mechanisms
aging,
reflecting
fact
genome
regulation
during
ontogenesis.
In
other
words,
not
leading
program,
but
rather
it
fixes
result
main
program
The
same
problems
are
inherent
markers
changes
RNA
synthesis
levels
different
genes.
our
opinion,
should
primarily
be
connected
with
or
directly
reflect
most
fundamental
bases
processes
which
universal
for
any
organisms.
arXiv (Cornell University),
Год журнала:
2023,
Номер
unknown
Опубликована: Янв. 1, 2023
Widespread
interest
in
non-destructive
biomarkers
of
aging
has
led
to
a
curse
plenty:
multitude
biological
ages
that
each
proffers
'true'
health-adjusted
age
an
individual.
While
measure
provides
salient
information
on
the
process,
they
are
univariate,
contrast
"hallmark"
and
"pillar"
theories
which
explicitly
multidimensional,
multicausal
multiscale.
Fortunately,
multiple
can
be
systematically
combined
into
multidimensional
network
representation.
The
interaction
between
these
permits
analysis
effects
aging,
as
well
quantification
causal
influences
during
both
natural
and,
potentially,
after
anti-aging
intervention.
behaviour
system
whole
then
explored
using
dynamical
stability
identifies
new,
efficient
quantify
long
term
resilience
scores
timescale
measurements
(years).
We
demonstrate
this
approach
set
8
from
longitudinal
Swedish
Adoption/Twin
Study
Aging
(SATSA).
After
extracting
ages,
we
observed
physiological
age,
proxy
for
cardiometabolic
health,
serves
central
node
network,
implicating
it
key
vulnerability
slow,
age-related
decline.
furthermore
show
while
is
stable,
there
weakly
stable
direction
along
recovery
slow
-
human
lifespan.
This
biomarker
correlates
strongly
with
chronological
predicts
decline
health
suggesting
estimates
important
driver
changes.
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 2, 2023
Abstract
Aging
clocks
have
provided
one
of
the
most
significant
recent
breakthroughs
in
biology
aging.
Such
allow
determination
chronological
and
increasingly
also
biological
age,
which
is
a
prerequisite
for
assessing
effectiveness
interventions
aging
process
preventive
treatments
age-related
diseases.
The
advanced
are
based
on
age-dependent
changes
DNA
methylation
pattern.
reproducibility
such
over
life
course
has
reinvigorated
debate
whether
programmed
underlies
A
process,
however,
incompatible
with
evolutionary
theory
occurs
as
consequence
vanishing
force
selective
pressure
post-reproduction
no
fitness
benefit
by
immortality
soma.
In
fact,
stochastic
events
been
observed
to
occur
during
process.
Here,
we
test
could
be
built
entirely
variation.
We
find
that
accumulating
variation
sufficient
accurately
predict
age.
Moreover,
current
compatible
random
alterations
or
transcriptomic
patterns.
Our
analysis
unifies
clock
measure
predicts
any
set
data
ground
state
at
age
zero
used
building
accurate
clocks.
