Male cuticular pheromones stimulate removal of the mating plug and promote re-mating through pC1 neurons in Drosophila females DOI Creative Commons
Minsik Yun, Do‐Hyoung Kim, Tal Soo Ha

и другие.

eLife, Год журнала: 2024, Номер 13

Опубликована: Сен. 10, 2024

In birds and insects, the female uptakes sperm for a specific duration post-copulation known as ejaculate holding period (EHP) before expelling unused mating plug through ejection. this study, we found that Drosophila melanogaster females shortens EHP when incubated with males or mated shortly after first mating. This phenomenon, which termed m ale- i nduced E HP s hortening (MIES), requires Or47b+ olfactory ppk23+ gustatory neurons, activated by 2-methyltetracosane 7-tricosene, respectively. These odorants raise cAMP levels in pC1 responsible processing male courtship cues regulating receptivity. Elevated neurons reduce reinstate their responsiveness to cues, promoting re-mating faster study established MIES genetically tractable model of sexual plasticity conserved neural mechanism.

Язык: Английский

A searchable image resource of Drosophila GAL4 driver expression patterns with single neuron resolution DOI Creative Commons
Geoffrey W. Meissner, Aljoscha Nern, Zachary Dorman

и другие.

eLife, Год журнала: 2023, Номер 12

Опубликована: Фев. 23, 2023

Precise, repeatable genetic access to specific neurons via GAL4/UAS and related methods is a key advantage of

Язык: Английский

Процитировано

83
Converting an allocentric goal into an egocentric steering signal DOI Creative Commons
Peter Mussells Pires, Lingwei Zhang,

Victoria Parache

и другие.

Nature, Год журнала: 2024, Номер 626(8000), С. 808 - 818

Опубликована: Фев. 7, 2024

Neuronal signals that are relevant for spatial navigation have been described in many species

Язык: Английский

Процитировано

45
Transforming descending input into behavior: The organization of premotor circuits in the Drosophila Male Adult Nerve Cord connectome DOI Open Access
Han SJ Cheong, Katharina Eichler, Tomke Stürner

и другие.

Опубликована: Март 18, 2024

In most animals, a relatively small number of descending neurons (DNs) connect higher brain centers in the animal’s head to circuits and motor (MNs) nerve cord body that effect movement limbs. To understand how signals generate behavior, it is critical these pathways are organized onto MNs. fly, Drosophila melanogaster , MNs controlling muscles leg, wing, other systems reside ventral (VNC), analogous mammalian spinal cord. companion papers, we introduced densely-reconstructed connectome Male Adult Nerve Cord (MANC, Takemura et al., 2023), including cell type developmental lineage annotation (Marin which provides complete VNC connectivity at synaptic resolution. Here, present first look organization networks connecting DNs based on this new information. We proofread curated all ensure accuracy reliability, then systematically matched DN axon terminals MN dendrites with light microscopy data link their morphology inputs or muscle targets. report both broad organizational patterns entire network fine-scale analysis selected interest. discover direct DN-MN connections infrequent identify communities intrinsic linked control different systems, putative for walking, dorsal flight steering power generation, intermediate lower tectulum coordinated action wings legs. Our generates hypotheses future functional experiments and, together MANC connectome, empowers others investigate richer mechanistic detail.

Язык: Английский

Процитировано

22
Nested neural circuits generate distinct acoustic signals during Drosophila courtship DOI Creative Commons
Joshua L. Lillvis, Kaiyu Wang, Hiroshi Shiozaki

и другие.

Current Biology, Год журнала: 2024, Номер 34(4), С. 808 - 824.e6

Опубликована: Янв. 30, 2024

Many motor control systems generate multiple movements using a common set of muscles. How are premotor circuits able to flexibly diverse movement patterns? Here, we characterize the neuronal that drive distinct courtship songs Drosophila melanogaster. Male flies vibrate their wings toward females produce two different song modes—pulse and sine song—which signal species identity male quality. Using cell-type-specific genetic reagents connectome, provide cellular synaptic map in ventral nerve cord these examine how activating or inhibiting each cell type within affects song. Our data reveal circuit is organized into nested feedforward pathways with extensive reciprocal feedback connections. The larger network produces pulse song, more complex ancestral form. A subset this simpler recent Such organization may be feature which evolution has layered increasing flexibility onto basic pattern.

Язык: Английский

Процитировано

21
Descending control and regulation of spontaneous flight turns in Drosophila DOI
Ivo G. Ros, Jaison J. Omoto, Michael H. Dickinson

и другие.

Current Biology, Год журнала: 2024, Номер 34(3), С. 531 - 540.e5

Опубликована: Янв. 15, 2024

Язык: Английский

Процитировано

17
Connectomics and the neural basis of behaviour DOI Creative Commons
Dana S. Galili, Gregory S.X.E. Jefferis, Marta Costa

и другие.

Current Opinion in Insect Science, Год журнала: 2022, Номер 54, С. 100968 - 100968

Опубликована: Сен. 13, 2022

Methods to acquire and process synaptic-resolution electron-microscopy datasets have progressed very rapidly, allowing production annotation of larger, more complete connectomes. More accurate neuronal matching techniques are enriching cell type data with gene expression, neuron activity, behaviour developmental information, providing ways test hypotheses circuit function. In a variety behaviours such as learned innate olfaction, navigation sexual behaviour, connectomics has already revealed interconnected modules hierarchical structure, recurrence integration sensory streams. Comparing individual connectomes determine which features robust variable is one key research area; new work in comparative across development, experience, sex species will establish strong links between connectivity brain

Язык: Английский

Процитировано

43
Virtual Fly Brain—An interactive atlas of the Drosophila nervous system DOI Creative Commons
Robert Court, Marta Costa, Clare Pilgrim

и другие.

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Янв. 26, 2023

As a model organism,

Язык: Английский

Процитировано

38
Transforming descending input into behavior: The organization of premotor circuits in theDrosophilaMale Adult Nerve Cord connectome DOI Creative Commons
Han SJ Cheong, Katharina Eichler, Tomke Stürner

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июнь 7, 2023

Abstract In most animals, a relatively small number of descending neurons (DNs) connect higher brain centers in the animal’s head to circuits and motor (MNs) nerve cord body that effect movement limbs. To understand how signals generate behavior, it is critical these pathways are organized onto MNs. fly, Drosophila melanogaster , MNs controlling muscles leg, wing, other systems reside ventral (VNC), analogous mammalian spinal cord. companion papers, we introduced densely-reconstructed connectome Male Adult Nerve Cord (MANC, Takemura et al., 2023), including cell type developmental lineage annotation (Marin which provides complete VNC connectivity at synaptic resolution. Here, present first look organization networks connecting DNs based on this new information. We proofread curated all ensure accuracy reliability, then systematically matched DN axon terminals MN dendrites with light microscopy data link their morphology inputs or muscle targets. report both broad organizational patterns entire network fine-scale analysis selected interest. discover direct DN-MN connections infrequent identify communities intrinsic linked control different systems, putative for walking, dorsal flight steering power generation, intermediate lower tectulum coordinated action wings legs. Our generates hypotheses future functional experiments and, together MANC connectome, empowers others investigate richer mechanistic detail.

Язык: Английский

Процитировано

37
Comparative connectomics of the descending and ascending neurons of theDrosophilanervous system: stereotypy and sexual dimorphism DOI Creative Commons
Tomke Stürner, P. D. Brooks, Laia Serratosa Capdevila

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 6, 2024

In most complex nervous systems there is a clear anatomical separation between the nerve cord, which contains of final motor outputs necessary for behaviour, and brain. insects, neck connective both physical information bottleneck connecting brain ventral cord (VNC, spinal analogue) comprises diverse populations descending (DN), ascending (AN) sensory neurons, are crucial sensorimotor signalling control. Integrating three separate EM datasets, we now provide complete connectomic description neurons female system

Язык: Английский

Процитировано

12
Transforming descending input into behavior: The organization of premotor circuits in the Drosophila Male Adult Nerve Cord connectome DOI Open Access
Han SJ Cheong, Katharina Eichler, Tomke Stürner

и другие.

Опубликована: Март 18, 2024

In most animals, a relatively small number of descending neurons (DNs) connect higher brain centers in the animal’s head to circuits and motor (MNs) nerve cord body that effect movement limbs. To understand how signals generate behavior, it is critical these pathways are organized onto MNs. fly, Drosophila melanogaster , MNs controlling muscles leg, wing, other systems reside ventral (VNC), analogous mammalian spinal cord. companion papers, we introduced densely-reconstructed connectome Male Adult Nerve Cord (MANC, Takemura et al., 2023), including cell type developmental lineage annotation (Marin which provides complete VNC connectivity at synaptic resolution. Here, present first look organization networks connecting DNs based on this new information. We proofread curated all ensure accuracy reliability, then systematically matched DN axon terminals MN dendrites with light microscopy data link their morphology inputs or muscle targets. report both broad organizational patterns entire network fine-scale analysis selected interest. discover direct DN-MN connections infrequent identify communities intrinsic linked control different systems, putative for walking, dorsal flight steering power generation, intermediate lower tectulum coordinated action wings legs. Our generates hypotheses future functional experiments and, together MANC connectome, empowers others investigate richer mechanistic detail.

Язык: Английский

Процитировано

9