Coordinated changes in a cortical circuit sculpt effects of novelty on neural dynamics DOI Creative Commons
Shinya Ito, Alex T. Piet, Corbett Bennett

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Окт. 23, 2023

Abstract Recent studies have found dramatic cell-type specific responses to stimulus novelty, highlighting the importance of analyzing cortical circuitry at level granularity understand brain function. Although initial work classified and characterized activity for each cell type, alterations in circuitry—particularly when multiple novelty effects interact—remain unclear. To address this gap, we employed a large-scale public dataset electrophysiological recordings visual cortex awake, behaving mice using Neuropixels probes designed population network models investigate observed changes neural dynamics response combination distinct forms novelty. The model parameters were rigorously constrained by publicly available structural datasets, including multi-patch synaptic physiology electron microscopy data. Our systematic optimization approach identified tens thousands parameter sets that replicate activity. Analysis these solutions revealed generally weaker connections under novel stimuli, as well shift balance e between SST VIP populations. Along with this, PV populations experienced overall more excitatory influences compared results also highlight role neurons aspects processing altering gain saturation conditions. In sum, our findings provide characterization how circuit adapts combining rich datasets.

Язык: Английский

Top-down input modulates visual context processing through an interneuron-specific circuit DOI Creative Commons

Georgia Bastos,

Jacob T. Holmes,

Jordan M. Ross

и другие.

Cell Reports, Год журнала: 2023, Номер 42(9), С. 113133 - 113133

Опубликована: Сен. 1, 2023

Visual stimuli that deviate from the current context elicit augmented responses in primary visual cortex (V1). These heightened responses, known as "deviance detection," require local inhibition V1 and top-down input anterior cingulate area (ACa). Here, we investigated mechanisms by which ACa interact to support deviance detection. Local field potential recordings mice during an oddball paradigm showed ACa-V1 synchrony peaks theta/alpha band (≈10 Hz). Two-photon imaging revealed mainly pyramidal neurons exhibited detection, while contextually redundant increased vasoactive intestinal peptide (VIP)-positive interneuron (VIP) activity decreased somatostatin-positive (SST) activity. Optogenetic drive of inputs at 10 Hz activated V1-VIPs but inhibited V1-SSTs, mirroring dynamics present paradigm. Chemogenetic disrupted Aca-V1 detection V1. results outline temporal interneuron-specific modulation processing.

Язык: Английский

Процитировано

25
Cooperative thalamocortical circuit mechanism for sensory prediction errors DOI Creative Commons

Shohei Furutachi,

Alexis D. Franklin, Andreea M. Aldea

и другие.

Nature, Год журнала: 2024, Номер 633(8029), С. 398 - 406

Опубликована: Авг. 28, 2024

Abstract The brain functions as a prediction machine, utilizing an internal model of the world to anticipate sensations and outcomes our actions. Discrepancies between expected actual events, referred errors, are leveraged update guide attention towards unexpected events 1–10 . Despite importance prediction-error signals for various neural computations across brain, surprisingly little is known about circuit mechanisms responsible their implementation. Here we describe thalamocortical disinhibitory that required generating sensory in mouse primary visual cortex (V1). We show violating animals’ predictions by stimulus preferentially boosts responses layer 2/3 V1 neurons most selective stimulus. Prediction errors specifically amplify input, rather than representing non-specific surprise or difference how input deviates from animal’s predictions. This amplification implemented cooperative mechanism requiring thalamic pulvinar cortical vasoactive-intestinal-peptide-expressing (VIP) inhibitory interneurons. In response VIP inhibit specific subpopulation somatostatin-expressing interneurons gate excitatory V1, resulting pulvinar-driven stimulus-selective V1. Therefore, prioritizes unpredicted information selectively increasing salience features through synergistic interaction neocortical circuits.

Язык: Английский

Процитировано

17
Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory DOI Creative Commons
Suhel Tamboli, Sanjay Singh,

Dimitry Topolnik

и другие.

Cell Reports, Год журнала: 2024, Номер 43(4), С. 114115 - 114115

Опубликована: Апрель 1, 2024

In the CA1 hippocampus, vasoactive intestinal polypeptide-expressing interneurons (VIP-INs) play a prominent role in disinhibitory circuit motifs. However, specific behavioral conditions that lead to disinhibition remain uncertain. To investigate relevance of VIP-IN activity, we employed wireless technologies allowing us monitor and manipulate their function freely behaving mice. Our findings reveal that, during spatial exploration new environments, VIP-INs hippocampal region become highly active, facilitating rapid encoding novel information. Remarkably, both pyramidal neurons (PNs) exhibit increased activity when encountering changes environment, including context- object-related alterations. Concurrently, somatostatin- parvalbumin-expressing inhibitory populations show an inverse relationship with PN revealing occurs on timescale seconds. Thus, VIP-IN-mediated may constitute crucial element novelty acquisition recognition memory.

Язык: Английский

Процитировано

11
Behavioral strategy shapes activation of the Vip-Sst disinhibitory circuit in visual cortex DOI Creative Commons
Alex T. Piet,

Nick Ponvert,

Douglas R. Ollerenshaw

и другие.

Neuron, Год журнала: 2024, Номер 112(11), С. 1876 - 1890.e4

Опубликована: Март 5, 2024

In complex environments, animals can adopt diverse strategies to find rewards. How distinct differentially engage brain circuits is not well understood. Here, we investigate this question, focusing on the cortical Vip-Sst disinhibitory circuit between vasoactive intestinal peptide-postive (Vip) interneurons and somatostatin-positive (Sst) interneurons. We characterize behavioral used by mice during a visual change detection task. Using dynamic logistic regression model, that individual use mixtures of comparison strategy statistical timing strategy. Separately, also have periods task engagement disengagement. Two-photon calcium imaging shows large strategy-dependent differences in neural activity excitatory, Sst inhibitory, Vip inhibitory cells response both image changes omissions. contrast, has limited effects population activity. diversity correlates be understood parsimoniously as increased activation strategy, which facilitates task-appropriate responses.

Язык: Английский

Процитировано

10
Integrating multimodal data to understand cortical circuit architecture and function DOI
Anton Arkhipov, Nuno Maçarico da Costa, Saskia de Vries

и другие.

Nature Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Язык: Английский

Процитировано

1
Top–down modulation in canonical cortical circuits with short-term plasticity DOI Creative Commons
Felix Waitzmann, Yue Kris Wu, Julijana Gjorgjieva

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(16)

Опубликована: Апрель 9, 2024

Cortical dynamics and computations are strongly influenced by diverse GABAergic interneurons, including those expressing parvalbumin (PV), somatostatin (SST), vasoactive intestinal peptide (VIP). Together with excitatory (E) neurons, they form a canonical microcircuit exhibit counterintuitive nonlinear phenomena. One instance of such phenomena is response reversal, whereby SST neurons show opposite responses to top–down modulation via VIP depending on the presence bottom–up sensory input, indicating that network may function in different regimes under stimulation conditions. Combining analytical computational approaches, we demonstrate model networks multiple interneuron subtypes experimentally identified short-term plasticity mechanisms can implement reversal. Surprisingly, despite not directly affecting activity, PV-to-E depression has decisive impact We how reversal relates inhibition stabilization paradoxical effect several demonstrating coincides change indispensability for stabilization. In summary, our work suggests role generating makes testable predictions.

Язык: Английский

Процитировано

8
Simple synaptic modulations implement diverse novelty computations DOI Creative Commons
Kyle Aitken, Luke Campagnola, Marina Garrett

и другие.

Cell Reports, Год журнала: 2024, Номер 43(5), С. 114188 - 114188

Опубликована: Май 1, 2024

Detecting novelty is ethologically useful for an organism's survival. Recent experiments characterize how different types of over timescales from seconds to weeks are reflected in the activity excitatory and inhibitory neuron types. Here, we introduce a learning mechanism, familiarity-modulated synapses (FMSs), consisting multiplicative modulations dependent on presynaptic or pre/postsynaptic activity. With FMSs, network responses that encode emerge under unsupervised continual minimal connectivity constraints. Implementing FMSs within experimentally constrained model visual cortical circuit, demonstrate generalizability by simultaneously fitting absolute, contextual, omission effects. Our also reproduces functional diversity cell subpopulations, leading testable predictions about synaptic dynamics can produce both population-level heterogeneous individual signals. Altogether, our findings simple plasticity mechanisms circuit structure qualitatively distinct complex responses.

Язык: Английский

Процитировано

7
Surprise and novelty in the brain DOI Creative Commons
Alireza Modirshanechi, Sophia Becker, Johanni Brea

и другие.

Current Opinion in Neurobiology, Год журнала: 2023, Номер 82, С. 102758 - 102758

Опубликована: Авг. 22, 2023

Язык: Английский

Процитировано

15
Cooperative thalamocortical circuit mechanism for sensory prediction errors DOI Open Access

Shohei Furutachi,

Alexis D. Franklin, Thomas D. Mrsic‐Flogel

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июль 12, 2023

Abstract The brain functions as a prediction machine, utilizing an internal model of the world to anticipate sensations and outcomes our actions. Discrepancies between expected actual events, referred errors, are leveraged update guide attention towards unexpected events 1–10 . Despite importance error signals for various neural computations across multiple regions, surprisingly little is known about circuit mechanisms responsible their implementation. Here we describe thalamocortical disinhibitory required generating sensory errors in mouse primary visual cortex (V1). Using calcium imaging with optogenetic manipulations mice traverse familiar virtual environment, show that violation animals’ predictions by stimulus preferentially boosts responses layer 2/3 V1 neurons most selective stimulus. Prediction specifically amplify input, rather than representing non-specific surprise or difference signal how input deviates from predictions. Selective amplification implemented cooperative mechanism requiring thalamic pulvinar, cortical vasoactive-intestinal-peptide-expressing (VIP) inhibitory interneurons. In response VIP inhibit specific subpopulation somatostatin-expressing (SOM) interneurons gate excitatory pulvinar V1, resulting pulvinar-driven response-amplification stimulus-selective V1. Therefore, prioritizes unpredicted information selectively increasing salience features through synergistic interaction neocortical circuits.

Язык: Английский

Процитировано

13
Synthetic surprise as the foundation of the psychedelic experience DOI Creative Commons
Roberto De Filippo, Dietmar Schmitz

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 157, С. 105538 - 105538

Опубликована: Янв. 15, 2024

Psychedelic agents, such as LSD and psilocybin, induce marked alterations in consciousness via activation of the 5-HT

Язык: Английский

Процитировано

4