COVID’s future: mini-waves rather than seasonal surges
Nature,
Год журнала:
2023,
Номер
617(7960), С. 229 - 230
Опубликована: Май 1, 2023
Язык: Английский
Continued evasion of neutralizing antibody response by Omicron XBB.1.16
Cell Reports,
Год журнала:
2023,
Номер
42(10), С. 113193 - 113193
Опубликована: Сен. 30, 2023
The
evolution
of
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
continues
to
challenge
the
efficacy
vaccination
efforts
against
disease
2019
(COVID-19).
Omicron
XBB
lineage
SARS-CoV-2
has
presented
dramatic
evasion
neutralizing
antibodies
stimulated
by
mRNA
and
COVID-19
convalescence.
XBB.1.16,
characterized
two
mutations
relative
dominating
variant
XBB.1.5,
i.e.,
E180V
K478R,
been
on
rise
globally.
In
this
study,
we
compare
immune
escape
XBB.1.16
with
alongside
ancestral
variants
D614G,
BA.2,
BA.4/5.
We
demonstrate
that
is
strongly
evasive,
extent
comparable
XBB.1.5
in
bivalent-vaccinated
healthcare
worker
sera,
3-dose-vaccinated
BA.4/5-wave
convalescent
sera.
Interestingly,
spike
less
fusogenic
than
phenotype
requires
both
K478R
manifest.
Overall,
our
findings
emphasize
importance
continued
surveillance
need
for
updated
vaccine
formulations.
Язык: Английский
What do we know about the Arcturus XBB.1.16 subvariant?
BMJ,
Год журнала:
2023,
Номер
unknown, С. p1074 - p1074
Опубликована: Май 16, 2023
COVID-19What
do
we
know
about
the
Arcturus
XBB.1.16subvariant?The
"Arcturus"
subvariant
of
SARS-CoV-2
has
been
making
headlines
for
weeks.Mun-Keat
Looi
reports
what
so
far
Mun-Keat
LooiWhat
is
XBB.1.16?
XBB.1.16is
yet
another
in
line
omicron
subvariants
that
began
with
BA.2.It
follows
on
from
XBB
and
XBB.1
related
to
XBB.1.5subvariant
("Kraken")
dominate
at
start
year.
1
Some
have
nicknamed
this
new
(meaning
"Guardian
Bear"
Greek)
distinguish
it
confusing
number
other
versions.The
X
signifies
these
came
through
a
recombination
two
or
more
sublineages
(in
case
BA.2.10.1.1
BA.2.75.3.1.1.1).
Язык: Английский
COV2Var, a function annotation database of SARS-CoV-2 genetic variation
Nucleic Acids Research,
Год журнала:
2023,
Номер
52(D1), С. D701 - D713
Опубликована: Окт. 28, 2023
The
COVID-19
pandemic,
caused
by
the
coronavirus
SARS-CoV-2,
has
resulted
in
loss
of
millions
lives
and
severe
global
economic
consequences.
Every
time
SARS-CoV-2
replicates,
viruses
acquire
new
mutations
their
genomes.
Mutations
genomes
led
to
increased
transmissibility,
disease
outcomes,
evasion
immune
response,
changes
clinical
manifestations
reducing
efficacy
vaccines
or
treatments.
To
date,
multiple
resources
provide
lists
detected
without
key
functional
annotations.
There
is
a
lack
research
examining
relationship
between
various
factors
such
as
severity,
pathogenicity,
patient
age,
gender,
cross-species
transmission,
viral
escape,
response
level,
transmission
capability,
evolution,
host
adaptability,
protein
structure,
function,
stability
concurrent
mutations.
Deep
understanding
mutation
sites
these
crucial
for
advancing
our
knowledge
developing
effective
responses.
fill
this
gap,
we
built
COV2Var,
function
annotation
database
genetic
variation,
available
at
http://biomedbdc.wchscu.cn/COV2Var/.
COV2Var
aims
identify
common
variants
assess
effects,
providing
valuable
resource
intensive
annotations
among
variants.
Язык: Английский
Key Essentials during the Transition from the Acute Phase of the COVID-19 Pandemic
Опубликована: Авг. 17, 2023
The
COVID-19
pandemic
has
been
met
with
an
unprecedented
response
from
the
scientific
community
leading
to
development,
study,
and
authorization
of
vaccines
antivirals,
ultimately
reducing
impact
SARS-CoV-2
on
global
public
health.
However,
is
far
being
eradicated,
continues
evolve,
causes
substantial
health
economic
burdens.
In
this
paper,
we
posit
essential
points
its
management
during
transition
acute
phase
pandemic.
As
discussed,
despite
Omicron
(sub)variant(s)
causing
clinically
milder
infections,
a
negligible
pathogen.
It
requires
continued
genomic
surveillance,
particularly
if
one
considers
that
future
(sub)lineages
do
not
necessarily
have
be
milder.
Antivirals
remain
elements
in
management.
former
could
benefit
further
development
improvements
dosing,
while
seasonal
administration
latter
simplification
increase
interest
tackle
vaccine
hesitancy.
also
ensure
accessibility
pharmaceuticals
low-income
countries
improve
understanding
their
use
context
long-term
goals
Regardless
location,
primary
role
awareness
education
must
played
by
healthcare
workers
who
directly
communicate
patients
serve
as
models
for
healthy
behaviors.
Язык: Английский
Unraveling the Dynamics of Omicron (BA.1, BA.2, and BA.5) Waves and Emergence of the Deltacron Variant: Genomic Epidemiology of the SARS-CoV-2 Epidemic in Cyprus (Oct 2021–Oct 2022)
Viruses,
Год журнала:
2023,
Номер
15(9), С. 1933 - 1933
Опубликована: Сен. 15, 2023
Commencing
in
December
2019
with
the
emergence
of
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
three
years
disease
(COVID-19)
pandemic
have
transpired.
The
virus
has
consistently
demonstrated
a
tendency
for
evolutionary
adaptation,
resulting
mutations
that
impact
both
immune
evasion
and
transmissibility.
This
ongoing
process
led
to
successive
waves
infections.
study
offers
comprehensive
assessment
spanning
genetic,
phylogenetic,
phylodynamic,
phylogeographic
dimensions,
focused
on
trajectory
SARS-CoV-2
epidemic
Cyprus.
Based
dataset
comprising
4700
viral
genomic
sequences
obtained
from
affected
individuals
between
October
2021
2022,
our
analysis
is
presented.
Over
this
timeframe,
total
167
distinct
lineages
sublineages
emerged,
including
variants
such
as
Delta
Omicron
(1,
2,
5).
Notably,
during
fifth
wave
infections,
subvariants
1
gained
prominence,
followed
by
ascendancy
5
subsequent
sixth
wave.
Additionally,
(December
2021-January
2022),
unique
set
genetic
associated
variant
1,
dubbed
"Deltacron",
was
identified.
phenomenon
initially
evoked
skepticism,
characterized
concerns
primarily
centered
around
contamination
or
coinfection
plausible
etiological
contributors.
These
hypotheses
were
predominantly
disseminated
through
unsubstantiated
assertions
within
realms
social
mass
media,
lacking
concurrent
scientific
evidence
validate
their
claims.
Nevertheless,
exhaustive
molecular
analyses
presented
occurrences
would
likely
lead
frameshift
mutation-a
aberration
conspicuously
absent
provided
sequences.
substantiates
accuracy
initial
assertion
while
refuting
potential
etiologies.
Comparable
observations
global
scale
dispelled
doubt,
eventually
leading
recognition
Delta-Omicron
community
monitoring
World
Health
Organization
(WHO).
As
investigation
delved
deeper
into
intricate
dynamics
Cyprus,
discernible
pattern
highlighting
major
role
international
connections
shaping
virus's
local
trajectory.
United
States
Kingdom
central
conduits
governing
entry
exit
Moreover,
notable
migratory
routes
included
nations
Greece,
South
Korea,
France,
Germany,
Brazil,
Spain,
Australia,
Denmark,
Sweden,
Italy.
empirical
findings
underscore
spread
Cyprus
markedly
influenced
influx
new,
highly
transmissible
variants,
triggering
infection.
elucidates
new
infection
advent
contagious
notably
an
abundance
localized
spike
protein.
discovery
decisively
contradicts
hitherto
hypothesis
seasonal
fluctuations
epidemiological
dynamics.
emphasizes
importance
meticulously
examining
genetics
alongside
migration
patterns
specific
region.
Past
experiences
also
emphasize
substantial
viruses
SARS-CoV-2,
underscoring
need
sustained
vigilance.
However,
pandemic's
continue
evolve,
balanced
approach
caution
resilience
becomes
paramount.
ethos
encourages
founded
informed
prudence
self-preservation,
guided
public
health
authorities,
rather
than
enduring
apprehension.
Such
empowers
societies
adapt
progress,
fostering
poised
confidence
rooted
well-founded
adaptation.
Язык: Английский
SARS‐CoV‐2 XBB.1.16 variant: India in focus?
Journal of Medical Virology,
Год журнала:
2023,
Номер
95(5)
Опубликована: Май 1, 2023
Язык: Английский
The mPOC Framework: An Autonomous Outbreak Prediction and Monitoring Platform Based on Wearable IoMT Approach
Future Internet,
Год журнала:
2023,
Номер
15(8), С. 257 - 257
Опубликована: Июль 30, 2023
This
paper
presents
the
mHealth
Predictive
Outbreak
for
COVID-19
(mPOC)
framework,
an
autonomous
platform
based
on
wearable
Internet
of
Medical
Things
(IoMT)
devices
outbreak
prediction
and
monitoring.
It
utilizes
real-time
physiological
environmental
data
to
assess
user
risk.
The
framework
incorporates
analysis
psychological
user-centric
data,
adopting
a
combination
top-down
bottom-up
approaches.
mPOC
mechanism
bidirectional
Mobile
Health
(mHealth)
Disaster
Recovery
System
(mDRS)
employs
intelligent
algorithm
calculate
Exposure
Index
(PEI)
Deterioration
Risk
(DRI).
These
indices
trigger
warnings
users
adaptive
threshold
criteria
provide
updates
Tracking
Center
(OTC).
provides
comprehensive
description
framework’s
mechanisms
algorithms,
complemented
by
performance
accuracy
evaluation.
By
leveraging
IoMT
devices,
showcases
its
potential
in
disease
prevention
control
during
pandemics,
offering
timely
alerts
vital
information
healthcare
professionals
individuals
mitigate
outbreaks’
impact.
Язык: Английский
Genomic surveillance of SARS-CoV-2 and emergence of XBB.1.16 variant in Rajasthan
Indian Journal of Medical Microbiology,
Год журнала:
2024,
Номер
50, С. 100659 - 100659
Опубликована: Июль 1, 2024
Genomic
surveillance
of
positive
SARS-CoV-2
samples
is
important
to
monitor
the
genetic
changes
occurring
in
virus,
this
was
enhanced
after
WHO
designation
XBB.1.16
as
a
variant
under
monitoring
March
2023.
From
5th
February
till
May
6,
2023
all
were
monitored
for
changes.
A
total
1757
having
Ct
value
<25
(for
E
and
ORF
gene)
from
different
districts
Rajasthan
processed
Next
Generation
Sequencing
(NGS).
The
FASTA
files
obtained
on
sequencing
used
lineage
determination
using
Nextclade
phylogenetic
tree
construction.
identification
done
1624
samples.
predominant
1413
(87.0%)
cases
while
rest
other
XBB
(207,
12.74%)
lineages
(4,
0.2%).
Of
cases,
57.47%
males
42.53%
females.
Majority
(66.53%)
belonged
19–59
year
age.
84.15%
infected
first
time.
Hospitalization
required
only
2.2%
death
reported
5
(0.35%)
patients.
Most
symptomatic
commonest
symptoms
fever,
cough
rhinorrhea.
Co-morbidities
present
414
(29.3%)
cases.
Enhanced
genomic
helped
rapidly
identify
spread
Rajasthan.
This
turn
take
control
measures
prevent
virus
estimate
public
health
risks
new
relative
previously
circulating
lineages.
found
but
produced
milder
disease.
Язык: Английский
MMS19 and IFIH1 Host Genetic Variants Associate with SARS-CoV-2 Infection in Elderly Residents of Long-Term Care Facilities
COVID,
Год журнала:
2024,
Номер
4(8), С. 1245 - 1252
Опубликована: Авг. 7, 2024
The
coronavirus
disease
2019
(COVID-19)
pandemic
has
significantly
affected
older
adults.
Identifying
host
COVID-19
susceptibility
genes
in
elderly
populations
remains
a
challenge.
Here,
we
aimed
to
identify
genetic
factors
influencing
the
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
infection.
We
genotyped
12
single-nucleotide
polymorphisms
(SNPs)
previously
associated
with
innate
immune
response
total
of
97
(age
>
65
years)
residents
three
long-term
care
facilities
located
Barcelona,
Spain.
Individuals
were
PCR-tested
during
SARS-CoV-2
outbreaks
between
September
and
November
2020.
PCR
tests
revealed
infections
81
residents.
Importantly,
16
uninfected
remained
seronegative
until
vaccination
(January
February
2021).
After
adjusting
for
sex
age,
found
that
two
SNPs
infection
susceptibility—MMS19
nucleotide
excision
repair
protein
homolog
(MMS19)/rs2236575
(p
=
0.029)
interferon-induced
helicase
C
domain-containing
1
(IFIH1)/rs1990760
0.034).
No
association
was
10
additional
SNPs,
which
included
4
on
chromosome
gene
encoding
oligoadenylate
synthetase
(OAS).
Our
results
indicate
MMS19/rs2236575_A
IFIH1/rs1990760_TC
variants
resistance
cohort
institutionalized
seniors.
Язык: Английский