Rotator cuff tears
Nature Reviews Disease Primers,
Год журнала:
2024,
Номер
10(1)
Опубликована: Фев. 8, 2024
Язык: Английский
Fork in the road: therapeutic and pathological actions for fibro‐adipogenic progenitors following musculoskeletal injury
The Journal of Physiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 11, 2025
Abstract
Musculoskeletal
injuries
are
a
substantial
source
of
global
disability
through
weakness
and
loss
function,
which
can
be
attributable,
in
part,
to
deficits
skeletal
muscle
quality.
Poor
quality,
resulting
from
fibrotic
pathology
or
fatty
infiltration,
strongly
predicts
lower
rates
patient
recovery
following
injury
higher
re‐injury.
The
cellular
sources
fibrosis
infiltration
within
mesenchymal
fibro‐adipogenic
progenitors
(FAPs),
central
effectors
support
homeostasis,
regeneration
growth.
However,
acute
chronic
musculoskeletal
injury,
FAPs
promote
fibro/fatty
that
is
likely
limit
repair.
Given
their
indispensable
role
muscle,
have
emerged
as
compelling
target
tissue
injury.
This
review
provides
insight
into
the
aetiology
FAP
activity
various
injuries,
addition
signalling
components
effect
differentiation.
Contrasting
with
therapeutic
potential,
disease‐
injury‐specific
activation
further
cements
crucial
improve
function
enhance
outcomes.
image
Язык: Английский
Large scale serum proteomics identifies proteins associated with performance decline and clinical milestones in Duchenne muscular dystrophy
N. Ikelaar,
A. M. Barnard,
S.W.M. Eng
и другие.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 7, 2024
Serum
biomarkers
are
promising
minimally
invasive
outcome
measures
in
clinical
studies
Duchenne
muscular
dystrophy
(DMD).
However,
strongly
associated
with
progression
and
predicting
performance
decline
lacking.
In
this
study
we
aimed
to
identify
serum
able
predict
milestones
DMD.
Towards
aim
present
a
retrospective
multi-center
cohort
including
samples
data
collected
research
participants
DMD
as
part
of
natural
history
at
the
University
Florida
(UF)
real-world
observations
Leiden
Medical
Center
(LUMC)
between
2009-2022.
The
7K
SomaScan
Язык: Английский