Large scale serum proteomics identifies proteins associated with performance decline and clinical milestones in Duchenne muscular dystrophy DOI Creative Commons

N. Ikelaar,

A. M. Barnard,

S.W.M. Eng

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 7, 2024

Serum biomarkers are promising minimally invasive outcome measures in clinical studies Duchenne muscular dystrophy (DMD). However, strongly associated with progression and predicting performance decline lacking. In this study we aimed to identify serum able predict milestones DMD. Towards aim present a retrospective multi-center cohort including samples data collected research participants DMD as part of natural history at the University Florida (UF) real-world observations Leiden Medical Center (LUMC) between 2009-2022. The 7K SomaScan

Language: Английский

Rotator cuff tears DOI
Asheesh Bedi, Julie Y. Bishop, Jay D. Keener

et al.

Nature Reviews Disease Primers, Journal Year: 2024, Volume and Issue: 10(1)

Published: Feb. 8, 2024

Language: Английский

Citations

51
Fork in the road: therapeutic and pathological actions for fibro‐adipogenic progenitors following musculoskeletal injury DOI Open Access
Allison M. Owen, Sara Gonzalez‐Velez, Alexander R. Keeble

et al.

The Journal of Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Abstract Musculoskeletal injuries are a substantial source of global disability through weakness and loss function, which can be attributable, in part, to deficits skeletal muscle quality. Poor quality, resulting from fibrotic pathology or fatty infiltration, strongly predicts lower rates patient recovery following injury higher re‐injury. The cellular sources fibrosis infiltration within mesenchymal fibro‐adipogenic progenitors (FAPs), central effectors support homeostasis, regeneration growth. However, acute chronic musculoskeletal injury, FAPs promote fibro/fatty that is likely limit repair. Given their indispensable role muscle, have emerged as compelling target tissue injury. This review provides insight into the aetiology FAP activity various injuries, addition signalling components effect differentiation. Contrasting with therapeutic potential, disease‐ injury‐specific activation further cements crucial improve function enhance outcomes. image

Language: Английский

Citations

0
Large scale serum proteomics identifies proteins associated with performance decline and clinical milestones in Duchenne muscular dystrophy DOI Creative Commons

N. Ikelaar,

A. M. Barnard,

S.W.M. Eng

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 7, 2024

Serum biomarkers are promising minimally invasive outcome measures in clinical studies Duchenne muscular dystrophy (DMD). However, strongly associated with progression and predicting performance decline lacking. In this study we aimed to identify serum able predict milestones DMD. Towards aim present a retrospective multi-center cohort including samples data collected research participants DMD as part of natural history at the University Florida (UF) real-world observations Leiden Medical Center (LUMC) between 2009-2022. The 7K SomaScan

Language: Английский

Citations

0