PARPs and ADP-ribosylation-mediated biomolecular condensates: determinants, dynamics, and disease implications
Trends in Biochemical Sciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Exosomal insights into ovarian cancer stem cells: revealing the molecular hubs
Journal of Ovarian Research,
Год журнала:
2025,
Номер
18(1)
Опубликована: Янв. 31, 2025
Ovarian
cancer
is
a
deadly
disease,
often
diagnosed
at
advanced
stages
due
to
lack
of
reliable
biomarkers.
Exosomes,
which
carry
variety
molecules
such
as
proteins,
lipids,
DNA,
and
non-coding
RNAs,
have
recently
emerged
promising
tools
for
early
detection.
While
exosomes
been
studied
in
various
types,
comprehensive
network
analyses
exosome
proteins
ovarian
remain
limited.
In
this
study,
we
used
protein-protein
interaction
(PPI)
network.
Using
the
Clustermaker2
app
MCODE
algorithm,
identified
six
significant
clusters
within
network,
highlighting
regions
involved
functional
pathways.
A
four-fold
algorithmic
approach,
including
MCC,
DMNC,
Degree,
EPC,
12
common
hub
genes.
STRING
analysis
visualization
techniques
provided
detailed
understanding
biological
processes
associated
with
these
Notably,
91.7%
genes
were
translational
processes,
showing
an
important
role
protein
synthesis
regulation
cancer.
addition,
miRNAs
LncRNAs
carried
by
exosomes.
These
findings
highlight
potential
biomarkers
detection
therapeutic
targets.
Язык: Английский
Stress granules in cancer: Adaptive dynamics and therapeutic implications
iScience,
Год журнала:
2024,
Номер
27(8), С. 110359 - 110359
Опубликована: Июнь 22, 2024
Stress
granules
(SGs),
membrane-less
cellular
organelles
formed
via
liquid-liquid
phase
separation,
are
central
to
how
cells
adapt
various
stress
conditions,
including
endoplasmic
reticulum
stress,
nutrient
scarcity,
and
hypoxia.
Recent
studies
have
underscored
a
significant
link
between
SGs
the
process
of
tumorigenesis,
highlighting
that
proteins,
associated
components,
signaling
pathways
facilitate
SG
formation
often
upregulated
in
cancer.
play
key
role
enhancing
tumor
cell
proliferation,
invasion,
migration,
while
also
inhibiting
apoptosis,
facilitating
immune
evasion,
driving
metabolic
reprogramming
through
multiple
mechanisms.
Furthermore,
been
identified
as
crucial
elements
development
resistance
against
chemotherapy,
immunotherapy,
radiotherapy
across
variety
cancer
types.
This
review
delves
into
complex
resistance,
bringing
together
latest
progress
field
exploring
new
avenues
for
therapeutic
intervention.
Язык: Английский
ADP-ribose hydrolases: biological functions and potential therapeutic targets
Expert Reviews in Molecular Medicine,
Год журнала:
2024,
Номер
26
Опубликована: Янв. 1, 2024
ADP-ribosylation
(ADPRylation),
which
encompasses
poly(ADP-ribosyl)ation
and
mono(ADP-ribosyl)ation,
is
an
important
post-translational
modification
catalysed
by
the
poly(ADP-ribose)
polymerase
(PARP)
enzyme
superfamily.
The
process
involves
writers
(PARPs)
erasers
(ADP-ribose
hydrolases),
work
together
to
precisely
regulate
diverse
cellular
molecular
responses.
Although
PARP-mediated
synthesis
of
ADP-ribose
(ADPr)
has
been
well
studied,
ADPr
degradation
degrading
enzymes
deserves
further
investigation.
Nonetheless,
recent
studies
have
provided
new
insights
into
biology
functions
hydrolases.
Notably,
research
illuminated
significance
pathway
its
activation
coordinated
actions
glycohydrolase
other
hydrolases,
identified
as
key
components
ADPRylation
signalling
networks.
proposed
play
crucial
roles
in
processes,
such
DNA
damage
repair,
chromatin
dynamics,
transcriptional
regulation
cell
death.
A
deep
understanding
these
erasing
provides
biological
human
health
disease
aetiology
paves
road
for
development
novel
therapeutic
strategies.
This
review
article
a
summary
current
knowledge
about
biochemical
their
physiological
implications
pathology.
Язык: Английский
Development and Characterization of Recombinant ADP-Ribose Binding Reagents that Allow Simultaneous Detection of Mono and Poly ADP-Ribose
Journal of Biological Chemistry,
Год журнала:
2024,
Номер
300(9), С. 107609 - 107609
Опубликована: Июль 27, 2024
Язык: Английский
Ribosomal rodeo: wrangling translational machinery in gynecologic tumors
Cancer and Metastasis Reviews,
Год журнала:
2024,
Номер
44(1)
Опубликована: Дек. 2, 2024
Gynecologic
cancers
are
a
significant
cause
of
morbidity
and
mortality
among
women
worldwide.
Despite
advancements
in
diagnosis
treatment,
the
molecular
mechanisms
underlying
development
progression
these
remain
poorly
understood.
Recent
studies
have
implicated
translational
machinery
(ribosomal
proteins
(RPs)
translation
factors
(TFs))
as
potential
drivers
oncogenic
processes
various
cancer
types,
including
gynecologic
cancers.
RPs
essential
components
ribosome,
which
is
responsible
for
protein
synthesis.
In
this
review
paper,
we
aim
to
explore
role
Specifically,
will
investigate
by
contribute
evaluate
feasibility
targeting
therapeutic
strategy.
By
doing
so,
hope
provide
broader
view
pathogenesis
highlight
their
novel
targets
management
challenging
diseases.
Язык: Английский