Genetic, Environmental, and Stochastic Components of Lifespan Variability: The Drosophila Paradigm

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(8), С. 4482 - 4482

Опубликована: Апрель 19, 2024

Lifespan is a complex quantitative trait involving genetic and non-genetic factors as well the peculiarities of ontogenesis. As with all traits, lifespan shows considerable variation within populations between individuals. Drosophila, favourite object geneticists, has greatly advanced our understanding how different forms variability affect lifespan. This review considers role heritable variability, phenotypic plasticity stochastic in controlling Drosophila melanogaster. We discuss major historical milestones development approach to study lifespan, breeding long-lived lines, advances QTL mapping, environmental that have greatest influence on laboratory maintained flies, mechanisms, by which individual affects longevity. The interplay approaches ageing limitation will also be discussed. Particular attention paid interaction types control

Язык: Английский

Invigorating discovery and clinical translation of aging biomarkers

Nature Aging, Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

Язык: Английский