The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease DOI Creative Commons
Agnes Carolin, David M. Frazer, Kexin Yan

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 29, 2024

Abstract The severity of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often dictated a range comorbidities. A considerable literature suggests iron deficiency and overload may contribute to increased infection, inflammation severity, although direct causal relationships have been difficult establish. Here we generate deficient loaded C57BL/6J mice feeding low high diets, with on normal diet representing controls. All were infected primary omicron XXB SARS-CoV-2 isolate lung inflammatory responses analyzed histology, immunohistochemistry RNA-Seq. Compared controls, showed no significant changes in viral loads or histopathology, whereas, slightly, but significantly, reduced histopathology. Transcriptional modest, illustrated widespread dysregulation signatures for both vs. Some these could be associated detrimental outcomes, whereas others would viewed as beneficial. Diet-associated thus induced modest modulations signatures, histopathologically detectable exacerbations. Author summary can lead anemia, problem worldwide. excessive less common, consumption supplements. We investigate herein using mouse model, whether diets predispose outcomes lungs after infection SARS-CoV-2. promote inflammation. However, found, modulations, unaffected slightly reduced, histopathology was either indicated disease. These findings do not support view that represent comorbidities predisposing overt COVID-19

Язык: Английский

Microplastics dysregulate innate immunity in the SARS-CoV-2 infected lung DOI Creative Commons

Cameron R. Bishop,

Kexin Yan, Wilson Nguyen

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Май 13, 2024

Introduction Global microplastic (MP) pollution is now well recognized, with humans and animals consuming inhaling MPs on a daily basis, growing body of concern surrounding the potential impacts human health. Methods Using mouse model mild COVID-19, we describe herein effects azide-free 1 μm polystyrene MP beads, co-delivered into lungs SARS-CoV-2 omicron BA.5 inoculum. The effect host response to infection was analysed using histopathology RNA-Seq at 2 6 days post-infection (dpi). Results Although reduced clearance from lung, virus titres viral RNA levels were not significantly affected by MPs, overt MP-associated clinical or histopathological changes observed. However, infected revealed that exposure suppressed innate immune responses dpi increased pro-inflammatory signatures dpi. cytokine profile showed significant correlation ‘cytokine release syndrome’ signature observed in some COVID-19 patients. Discussion findings are consistent recent finding can inhibit phagocytosis apoptotic cells via binding Tim4. They also add literature suggesting dysregulate inflammatory processes specific disease settings.

Язык: Английский

Процитировано

10
The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease DOI Creative Commons
Agnes Carolin, David M. Frazer, Kexin Yan

и другие.

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Сен. 4, 2024

The severity of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often dictated a range comorbidities. A considerable literature suggests iron deficiency and overload may contribute to increased infection, inflammation severity, although direct causal relationships have been difficult establish.

Язык: Английский

Процитировано

1
The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease DOI Creative Commons
Agnes Carolin, David M. Frazer, Kexin Yan

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 29, 2024

Abstract The severity of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often dictated a range comorbidities. A considerable literature suggests iron deficiency and overload may contribute to increased infection, inflammation severity, although direct causal relationships have been difficult establish. Here we generate deficient loaded C57BL/6J mice feeding low high diets, with on normal diet representing controls. All were infected primary omicron XXB SARS-CoV-2 isolate lung inflammatory responses analyzed histology, immunohistochemistry RNA-Seq. Compared controls, showed no significant changes in viral loads or histopathology, whereas, slightly, but significantly, reduced histopathology. Transcriptional modest, illustrated widespread dysregulation signatures for both vs. Some these could be associated detrimental outcomes, whereas others would viewed as beneficial. Diet-associated thus induced modest modulations signatures, histopathologically detectable exacerbations. Author summary can lead anemia, problem worldwide. excessive less common, consumption supplements. We investigate herein using mouse model, whether diets predispose outcomes lungs after infection SARS-CoV-2. promote inflammation. However, found, modulations, unaffected slightly reduced, histopathology was either indicated disease. These findings do not support view that represent comorbidities predisposing overt COVID-19

Язык: Английский

Процитировано

0