THE EFFECT OF NANOPLASTICS AND MICROPLASTICS ON LUNG MORPHOLOGY AND PHYSIOLOGY: A SYSTEMATIC REVIEW DOI Creative Commons

Y.V. Rybalchenko

The Medical and Ecological Problems, Год журнала: 2024, Номер 28(3), С. 42 - 60

Опубликована: Дек. 30, 2024

Airborne microplastic (NP) and nanoplastic (MP) pollution has emerged as a pressing environmental concern with significant implications for human health. While MPs are present both indoors outdoors, indoor concentrations generally higher due to the abrasion of household materials, furniture, other domestic sources. NPs, when inhaled, accumulate in various lung regions, exerting toxic effects potentially leading respiratory diseases. This systematic review, conducted according PRISMA guidelines, evaluates recent experimental studies on pathogenic impact nanomicroplastics (NMPs) tissues using vivo vitro models. The review included 10 analyzing MP accumulation 90 examining pathogenetic mechanisms exposure. Research data indicates predominance polymeric fibers such polypropylene, polyethylene terephthalate, polytetrafluoroethylene, accounting nearly half structures. NMPs exhibit size- composition-dependent accumulation, smaller positively charged particles showing translocation potential systemic circulation organs. highlights synergistic heavy metals pollutants, interaction pulmonary surfactant, role exacerbating Current analysis underscores growing interest NMP-related health risks identifies knowledge gaps, including need standardization NMP toxicity testing further exploration biological systems. findings emphasize importance mitigating exposure safeguard pave way future research long-term impacts airborne

Язык: Английский

The alarming link between environmental microplastics and health hazards with special emphasis on cancer DOI

Sohini Goswami,

Satadal Adhikary, Suchandra Bhattacharya

и другие.

Life Sciences, Год журнала: 2024, Номер 355, С. 122937 - 122937

Опубликована: Авг. 3, 2024

Язык: Английский

Процитировано

27
Degradation of Polymer Materials in the Environment and Its Impact on the Health of Experimental Animals: A Review DOI Open Access
X. Zhang, Zhenxing Yin,

Songbai Xiang

и другие.

Polymers, Год журнала: 2024, Номер 16(19), С. 2807 - 2807

Опубликована: Окт. 3, 2024

The extensive use of polymeric materials has resulted in significant environmental pollution, prompting the need for a deeper understanding their degradation processes and impacts. This review provides comprehensive analysis environment impact on health experimental animals. It identifies common polymers, delineates pathways, describes resulting products under different conditions. covers physical, chemical, biological mechanisms, highlighting complex interplay factors influencing these processes. Furthermore, it examines implications products, using animals as proxies assessing potential risks to human health. By synthesizing current research, focuses studies related small organisms (primarily rodents invertebrates, supplemented by fish mollusks) explore effects polymer living underscores urgency developing implementing effective waste management strategies. These strategies are crucial mitigating adverse impacts degradation, thus promoting more sustainable interaction between activities natural environment.

Язык: Английский

Процитировано

15
Mechanisms of exacerbation of Th2-mediated eosinophilic allergic asthma induced by plastic pollution derivatives (PPD): A molecular toxicological study involving lung cell ferroptosis and metabolomics DOI

Huaqin Wei,

Surui Lu,

Mingqing Chen

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 946, С. 174482 - 174482

Опубликована: Июль 3, 2024

Язык: Английский

Процитировано

10
Tracking inflammation resolution signatures in lungs after SARS-CoV-2 omicron BA.1 infection of K18-hACE2 mice DOI Creative Commons
Agnes Carolin, Kexin Yan, Cameron Bishop

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 13, 2024

Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus Disease 2019 (COVID-19), which can result in disease, often characterised by a ‘cytokine storm’ and the associated distress syndrome. However, many infections with SARS-CoV-2 are mild or asymptomatic throughout course of infection. Although blood biomarkers disease well studied, less understood inflammatory signatures lung tissues silent infections, wherein infection inflammation rapidly resolved leading to sequelae-free recovery. Herein we described RNA-Seq histological analyses lungs over time an omicron BA.1/K18-hACE2 mouse model, displays these latter features. robust was evident at days post (dpi), viral RNA largely cleared 10 dpi. Acute showed slightly different pattern cytokine compared models, where much diminished 30 dpi absent 66 Cellular deconvolution identified significantly increased abundance scores for number anti-inflammatory pro-resolution cell types 5/10 These included type II innate lymphoid cells, T regulatory interstitial macrophages. Genes whose expression trended downwards – were pathways. upward during this period recovery ciliated AT2 AT1 transition, reticular fibroblasts indicating return homeostasis. Very few differentially expressed host genes dpi, suggesting near complete parallels between subclinical humans those observed model discussed reference concept “protective inflammation”.

Язык: Английский

Процитировано

3
Elevated Micro- and Nanoplastics Detected in Preterm Human Placentae DOI Creative Commons
Michael D. Jochum,

Marcus Garcia,

Alexandra Hammerquist

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Abstract Recent analytical advancements have uncovered increasing micro- and nanoplastics (MNPs) in environmental, dietary, biological domains, raising concerns about their health impacts. Preterm birth (PTB), a leading cause of maternal neonatal morbidity mortality, may be influenced by MNP exposure, yet this relationship remains unexplored. This study quantified 12 polymers placentae from term (n=87) preterm (n=71) deliveries using pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS). Cumulative concentrations were 28% higher PTB (mean ±SD: 224.7 ± 180.7 µg/g vs. 175.5 137.9 µg/g; p=0.038). Polyvinyl chloride (PVC), polyethylene terephthalate (PET), polyurethane (PU), polycarbonate (PC) significantly elevated PTB, PET, PU, PC inversely correlated with gestational age weight. Logistic regression identified PVC as independent predictors PTB. These findings suggest total specific MNPs are associated providing actionable insights emphasizing the importance minimizing exposure during pregnancy.

Язык: Английский

Процитировано

0
Organ-specific accumulation and toxicity analysis of orally administered polyethylene terephthalate microplastics DOI Creative Commons
Dong-Seon Kim, Dongmin Kim, Hee-Kyung Kim

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 24, 2025

Microplastics (MPs), plastic particles with a diameter of < 5 mm, are intentionally produced or formed by the breakdown variety larger plastics. Polyethylene terephthalate (PET) is common source MPs and PET-MPs prevalent in environment. Owing to their persistence, can enter ecosystems, air, food sources, posing significant health risks. This study aimed investigate toxicological effects vivo accumulation smaller than 10 µm. To track biodistribution, fluorescently labeled were prepared. Particle size morphology confirmed using physical chemical characterization. Following oral administration ICR (CD-1®) outbred mice, occurred predominantly lungs, as IVIS spectrum CT analysis ex imaging. Toxicity assays revealed development granulomatous inflammation lungs at medium high doses, indicating concentration-dependent response. The recorded no-observed-adverse-effect levels 1.75 mg/kg for males 7 females. highlights potential induce persistent respiratory tissues reveals need further research support regulatory standards long-term MP exposure.

Язык: Английский

Процитировано

0
Air pollution and its impacts on health: Focus on microplastics and nanoplastics DOI
Yung‐Li Wang, Y. Lin, Wen‐Chih Liu

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 299, С. 118402 - 118402

Опубликована: Май 26, 2025

Язык: Английский

Процитировано

0
Unveiling the impact of microplastics: a perspective on size, shape, and composition in human health DOI
Ok‐Hyeon Kim, Eric L. Chang, Hana Kang

и другие.

Molecular & Cellular Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Май 26, 2025

Язык: Английский

Процитировано

0
The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease DOI Creative Commons
Agnes Carolin, David M. Frazer, Kexin Yan

и другие.

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Сен. 4, 2024

The severity of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often dictated a range comorbidities. A considerable literature suggests iron deficiency and overload may contribute to increased infection, inflammation severity, although direct causal relationships have been difficult establish.

Язык: Английский

Процитировано

1
The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease DOI Creative Commons
Agnes Carolin, David M. Frazer, Kexin Yan

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 29, 2024

Abstract The severity of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often dictated a range comorbidities. A considerable literature suggests iron deficiency and overload may contribute to increased infection, inflammation severity, although direct causal relationships have been difficult establish. Here we generate deficient loaded C57BL/6J mice feeding low high diets, with on normal diet representing controls. All were infected primary omicron XXB SARS-CoV-2 isolate lung inflammatory responses analyzed histology, immunohistochemistry RNA-Seq. Compared controls, showed no significant changes in viral loads or histopathology, whereas, slightly, but significantly, reduced histopathology. Transcriptional modest, illustrated widespread dysregulation signatures for both vs. Some these could be associated detrimental outcomes, whereas others would viewed as beneficial. Diet-associated thus induced modest modulations signatures, histopathologically detectable exacerbations. Author summary can lead anemia, problem worldwide. excessive less common, consumption supplements. We investigate herein using mouse model, whether diets predispose outcomes lungs after infection SARS-CoV-2. promote inflammation. However, found, modulations, unaffected slightly reduced, histopathology was either indicated disease. These findings do not support view that represent comorbidities predisposing overt COVID-19

Язык: Английский

Процитировано

0