Pharmacological Research, Год журнала: 2020, Номер 164, С. 105364 - 105364
Опубликована: Дек. 4, 2020
Язык: Английский
Cancers, Год журнала: 2020, Номер 12(12), С. 3532 - 3532
Опубликована: Ноя. 26, 2020
In recent years, advances in artificial intelligence (AI) technology have led to the rapid clinical implementation of devices with AI medical field. More than 60 AI-equipped already been approved by Food and Drug Administration (FDA) United States, active introduction is considered be an inevitable trend future medicine. field oncology, applications using are underway, mainly radiology, expected positioned as important core technology. particular, “precision medicine,” a treatment that selects most appropriate for each patient based on vast amount data such genome information, has become worldwide trend; utilized process extracting truly useful information from large applying it diagnosis treatment. this review, we would like introduce history current state AI, especially oncology field, well discuss possibilities challenges
Язык: Английский
Процитировано
158
Molecules, Год журнала: 2021, Номер 26(9), С. 2506 - 2506
Опубликована: Апрель 25, 2021
Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and experimental studies have documented that melatonin could inhibit different types of cancer in vitro vivo. Results showed the involvement anticancer mechanisms including apoptosis induction, cell proliferation inhibition, reduction tumor growth metastases, side effects associated chemotherapy radiotherapy, decreasing drug resistance therapy, augmentation therapeutic conventional therapies. Clinical trials revealed an effective adjuvant to all This review summarized biosynthesis, availability from natural sources, metabolism, bioavailability, melatonin, its use clinical trials, pharmaceutical formulation. Studies discussed this will provide solid foundation for researchers physicians design develop new therapies treat prevent using melatonin.
Язык: Английский
Процитировано
155
Cancers, Год журнала: 2020, Номер 12(5), С. 1232 - 1232
Опубликована: Май 14, 2020
The tumor microenvironment (TME) is a complex system composed of multiple cells, such as non-cancerous fibroblasts, adipocytes, immune and vascular well signal molecules mediators. Tumor cells recruit reprogram other to produce factors that maintain growth. Communication between cancerous surrounding two-way process engages diverse range mechanisms that, in consequence, can lead rapid proliferation, metastasis, drug resistance, or serve tumors-suppressor, e.g., through tumor–immune cell interaction. Cross-talk within the cancer be direct by cell-to-cell contact via adhesion molecules, electrical coupling, passage gap junctions, indirect classical paracrine signaling cytokines, growth factors, extracellular vesicles. Therapeutic approaches for modulation cell-cell communication may promising strategy combat tumors. In particular, integrative targeting combination with conventional chemotherapy seem reasonable. Currently, special attention paid suppressing formation open-ended channels blocking exosome production ablating their cargos. However, many aspects have yet clarified, and, more work needed regard bidirectional transfer. Finally, it seems some interactions TEM not only cancer-specific, but also patient-specific, recognition would help predict patient response therapy.
Язык: Английский
Процитировано
146
Cells, Год журнала: 2021, Номер 10(12), С. 3288 - 3288
Опубликована: Ноя. 24, 2021
G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling known to play a crucial role in various physiological functions, including tumor growth and metastasis. Various molecules such as hormones, lipids, peptides, neurotransmitters activate GPCRs that enable coupling these highly specialized transducer proteins, called G-proteins, initiate multiple pathways. Integration intricate networks cascades leads numerous biochemical responses involved diverse pathophysiological activities, cancer development. While several studies indicate controlling aspects progression growth, invasion, migration, survival, metastasis through its aberrant overexpression, mutations, or increased release agonists, explicit mechanisms involvement is still puzzling. This review provides an insight into mediated by development cancers, molecular novel pharmacological approaches currently preferred for treatment cancer. Thus, findings extend knowledge cells help identification therapeutics patients.
Язык: Английский
Процитировано
146
Pharmacological Research, Год журнала: 2020, Номер 164, С. 105364 - 105364
Опубликована: Дек. 4, 2020
Язык: Английский
Процитировано
143