Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

Cell, Год журнала: 2019, Номер 179(2), С. 312 - 339

Опубликована: Сен. 26, 2019

Язык: Английский

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The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

Neuron, Год журнала: 2014, Номер 82(4), С. 756 - 771

Опубликована: Май 1, 2014

Язык: Английский

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Alzheimer’s and Parkinson’s diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein

Science, Год журнала: 2015, Номер 349(6248)

Опубликована: Авг. 6, 2015

Converging paradigms in neurodegeneration Parkinson's disease and Alzheimer's are progressive neurodegenerative diseases with increasing prevalence our aging populations. Recent evidence suggests that some of the molecular mechanisms involved pathology these have similarities to those observed infectious prion such as bovine spongiform encephalopathy (mad cow disease). Goedert reviews how spread a variety pathological protein aggregates is disease. Science , this issue p. 10.1126/science.1255555

Язык: Английский

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Amyloid β Protein and Alzheimer’s Disease: When Computer Simulations Complement Experimental Studies

Chemical Reviews, Год журнала: 2015, Номер 115(9), С. 3518 - 3563

Опубликована: Март 19, 2015

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTAmyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental StudiesJessica Nasica-Labouze†, Phuong H. Nguyen†, Fabio Sterpone†, Olivia Berthoumieu‡, Nicolae-Viorel Buchete§, Sébastien Coté∥, Alfonso De Simone⊥, Andrew J. Doig#, Peter Faller‡, Angel Garcia∇, Alessandro Laio○, Mai Suan Li◆¶, Simone Melchionna⬠, Normand Mousseau§, Yuguang Mu▲, Anant Paravastu◇⊕, Samuela Pasquali†, David Rosenman●, Birgit Strodel△, Bogdan Tarus†, John Viles▼, Tong Zhang†▲, Chunyu Wang◇, Philippe Derreumaux*†□View Author Information† Laboratoire de Biochimie Théorique, Institut Biologie Physico-Chimique (IBPC), UPR9080 CNRS, Université Paris Diderot, Sorbonne Cité, 13 rue Pierre et Marie Curie, 75005 Paris, France‡ LCC (Laboratoire Chimie Coordination), Toulouse, Paul Sabatier (UPS), National Polytechnique Toulouse (INPT), 205 route Narbonne, BP 44099, F-31077 Cedex 4, France§ School of Physics & Complex Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin Ireland∥ Département Physique Groupe recherche sur les protéines membranaires (GEPROM), Montréal, C.P. 6128, succursale Centre-ville, Québec H3C 3T5, Canada⊥ Department Life Sciences, Imperial London, London SW7 2AZ, United Kingdom# Manchester Institute Biotechnology, Manchester, 131 Princess Street, M1 7DN, Kingdom● ∇Department Physics, Applied Astronomy, ●Department Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, States○ The International for Advanced Studies (SISSA), Via Bonomea 265, 34136 Trieste, Italy◆ Polish Academy Al. Lotnikow 32/46, 02-668 Warsaw, Poland¶ Computational Science Technology, SBI Building, Quang Trung Software City, Tan Chanh Hiep Ward, District 12, Ho Chi Minh Vietnam⬠ Instituto Processi Chimico-Fisici, CNR-IPCF, Consiglio Nazionale delle Ricerche, 00185 Roma, Italy▲ Biological Nanyang Technological University, 60 Drive, 637551 Singapore◇ Chemical Biomedical Engineering, Florida A&M University-Florida State (FAMU-FSU) 2525 Pottsdamer Tallahassee, 32310, States⊕ High Magnetic Field 1800 East Dirac States△ Systems: Structural Biochemistry (ICS-6), Forschungszentrum Jülich GmbH, 52425 Jülich, Germany▼ Queen Mary E1 4NS, Kingdom□ Universitaire France, France*Phone: 33 1 58 41 51 72. E-mail: [email protected]Cite this: Chem. Rev. 2015, 115, 9, 3518–3563Publication Date (Web):March 19, 2015Publication History Received7 November 2014Published online19 March 2015Published inissue May 2015https://pubs.acs.org/doi/10.1021/cr500638nhttps://doi.org/10.1021/cr500638nreview-articleACS PublicationsCopyright © 2015 American SocietyRequest reuse permissionsArticle Views10948Altmetric-Citations502LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chemical structure,Monomers,Nanofibers,Oligomers,Peptides proteins Get e-Alerts

Язык: Английский

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Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

Nature Communications, Год журнала: 2015, Номер 6(1)

Опубликована: Янв. 29, 2015

In Alzheimer’s disease (AD), β-amyloid (Aβ) plaques are tightly enveloped by microglia processes, but the significance of this phenomenon is unknown. Here we show that constitute a barrier with profound impact on plaque composition and toxicity. Using high-resolution confocal in vivo two-photon imaging AD mouse models, demonstrate prevents outward expansion leads to compact microregions low Aβ42 affinity. Areas uncovered less have high affinity, leading formation protofibrillar hotspots associated more severe axonal dystrophy. ageing, coverage reduced enlarged neuritic CX3CR1 gene deletion or anti-Aβ immunotherapy causes Failure accumulation neurotoxic Aβ may novel therapeutic clinical targets for AD. authors used vivotwo-photon models revealed seems prevent β-amyloid.

Язык: Английский

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Biochemistry of Amyloid -Protein and Amyloid Deposits in Alzheimer Disease

Cold Spring Harbor Perspectives in Medicine, Год журнала: 2012, Номер 2(6), С. a006262 - a006262

Опубликована: Фев. 21, 2012

Colin L. Masters1 and Dennis J. Selkoe2 The Mental Health Research Institute, University of Melbourne, Parkville 3010, Australia Center for Neurologic Diseases, Harvard Medical School Brigham Women's Hospital, Boston, Massachusetts 02115 Correspondence: c.masters{at}unimelb.edu.au

Язык: Английский

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Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease

Cell Death and Differentiation, Год журнала: 2021, Номер 28(5), С. 1548 - 1562

Опубликована: Янв. 4, 2021

Abstract Iron homeostasis disturbance has been implicated in Alzheimer’s disease (AD), and excess iron exacerbates oxidative damage cognitive defects. Ferroptosis is a nonapoptotic form of cell death dependent upon intracellular iron. However, the involvement ferroptosis pathogenesis AD remains elusive. Here, we report that ferroportin1 (Fpn), only identified mammalian nonheme exporter, was downregulated brains APPswe/PS1dE9 mice as an mouse model patients. Genetic deletion Fpn principal neurons neocortex hippocampus by breeding fl/fl with NEX-Cre led to AD-like hippocampal atrophy memory deficits. Interestingly, canonical morphological molecular characteristics were observed both fl/fl/NEXcre mice. Gene set enrichment analysis (GSEA) ferroptosis-related RNA-seq data showed differentially expressed genes highly enriched gene sets associated AD. Furthermore, administration specific inhibitors effectively reduced neuronal impairments induced Aβ aggregation vitro vivo. In addition, restoring ameliorated impairment Our study demonstrates critical role progression AD, thus provides promising therapeutic approaches for this disease.

Язык: Английский

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The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease

Brain, Год журнала: 2015, Номер 138(10), С. 2814 - 2833

Опубликована: Авг. 17, 2015

Abnormal tau lesions (non-argyrophilic pretangle material, argyrophilic neuropil threads, neurofibrillary tangles) in select types of neurons are crucial for the pathogenesis sporadic Alzheimer's disease. Ongoing formation these persists into end-stage disease and is not subject to remission. The early phase a focus increasing interest because only abnormal forms microtubule-associated protein involved at that point and, contrast late-stage when amyloid-β deposition present, this temporally closer prevailing conditions induce pathological process underlying Extracellular aggregated may be produced under by nerve cells contain tau. One potential trigger hyperphosphorylation conformational change presence non-endogenous pathogen. Subsequently, predictable regional distribution pattern develops phylogenetically late-appearing ontogenetically late-maturing connected via their axons. It hoped hypotheses drawn from considerations, as well recent dissemination models, studies variant conformers, imaging will encourage development new preventative disease-modifying strategies.

Язык: Английский

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Tau imaging: early progress and future directions

The Lancet Neurology, Год журнала: 2014, Номер 14(1), С. 114 - 124

Опубликована: Дек. 8, 2014

Язык: Английский

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Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)

Chemical Reviews, Год журнала: 2014, Номер 114(13), С. 6661 - 6714

Опубликована: Июнь 5, 2014

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTPhysicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)Francois-Xavier Theillet†, Andres Binolfi†, Tamara Frembgen-Kesner‡, Karan Hingorani§, Mohona Sarkar∥, Ciara Kyne⊥, Conggang Li#, Peter B. Crowley⊥, Lila Gierasch§, Gary J. Pielak∥, Adrian H. Elcock‡, Anne Gershenson§, Philipp Selenko*†View Author Information† Department NMR-supported Structural Biology, In-cell NMR Laboratory, Leibniz Institute Molecular Pharmacology (FMP Berlin), Robert-Roessle Strasse 10, 13125 Berlin, Germany‡ Biochemistry, University Iowa, Bowen Science Building, 51 Newton Road, Iowa City, 52242, United States§ Departments Biochemistry & Biology Chemistry, Program in Cellular Massachusetts, Amherst, 240 Thatcher Way, Massachusetts 01003, States∥ Biophysics Lineberger Comprehensive Cancer Center, North Carolina, Chapel Hill, Carolina 27599-3290, States⊥ School National Ireland, Galway, Ireland# Key Laboratory Magnetic Resonance Biological Systems, State Atomic Physics, Wuhan Center for Resonance, Physics Mathematics, Chinese Academy Sciences, Wuhan, 430071, P.R. China*E-mail: [email protected]Cite this: Chem. Rev. 2014, 114, 13, 6661–6714Publication Date (Web):June 5, 2014Publication History Received9 December 2013Published online5 June 2014Published inissue 9 July 2014https://doi.org/10.1021/cr400695pCopyright © 2014 American Chemical SocietyRIGHTS PERMISSIONSACS AuthorChoiceArticle Views17541Altmetric-Citations302LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InReddit (20 MB) Get e-AlertsSUBJECTS:Aggregation,Diffusion,Fluorescence,Monomers,Peptides proteins e-Alerts

Язык: Английский

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