African Health Sciences,
Год журнала:
2017,
Номер
16(4), С. 1045 - 1045
Опубликована: Март 7, 2017
Background:
Alzheimer's
disease
has
a
destructive
drawbacks
on
the
patient
and
his/her
entire
family
as
this
badly
affects
behavior,
cognition
abilities
to
do
activities
of
daily
living
(ADL).
The
physical
mental
benefits
exercise
are
widely
known
but
seldom
available
persons
suffering
from
disease.Objective:
aim
study
was
measure
quality
life,
systemic
inflammation
psychological
well-being
response
aerobic
exercises
in
Alzheimer's.Methods:
Forty
Alzheimer
elderly
subjects
were
enrolled
two
groups;
first
group
received
treadmill
exercise,
while
second
considered
control
no
training
intervention
for
months.
Assessment
tumor
necrosis
factor-alpha
(TNF-α),
interleukin-6
(IL-6),
Rosenberg
Self-Esteem
Scale
(RSES),Beck
Depression
Inventory
(BDI),
Profile
Mood
States(POMS)
SF-36
health
life
(SF-36
HRQL)
taken
before
at
end
study.Results:
There
25.2%,
19.4%,
23.5%,
21.3%,
17.7%
,
11.7%,
12.5%
10.1
%
reduction
mean
values
TNF-α,
IL-6,
BDI,
POMS,
transition
subscale,
bodily
pain
role
functioning:
emotional
subscale
respectively
addition
15.7%,
13.1%,
12.6%,
11.1%,
13.2%
11.2
increase
RSES,
functioning
functioning:physical
general
Vitality
Social
(A)
training,
so
that
there
significant
BDI
&
POMS
HRQL
scores,
RSES
result
results
(B)
who
not
significant.
Also,
differences
between
levels
investigated
parameters
(P<0.05).Conclusion:
Treadmill
walking
is
an
effective
treatment
policy
improve
wellbeing
Alzheimer's.Keywords:
Aerobic
well-being,
inflammation,
Abstract
Amyloid
precursor
protein
(APP)
is
critically
involved
in
the
pathophysiology
of
Alzheimer’s
disease,
but
its
physiological
functions
remain
elusive.
Importantly,
APP
knockout
(APP-KO)
mice
exhibit
cognitive
deficits,
suggesting
that
plays
a
role
at
neuronal
network
level.
To
investigate
this
possibility,
we
recorded
local
field
potentials
(LFPs)
from
posterior
parietal
cortex,
dorsal
hippocampus
and
lateral
prefrontal
cortex
freely
moving
APP-KO
mice.
Spectral
analyses
showed
oscillations
within
theta-
gamma-frequency
bands
were
not
different
between
wild-type
Surprisingly,
however,
while
gamma
amplitude
coupled
to
theta
phase
all
regions
animals,
theta-gamma
coupling
was
strongly
diminished
recordings
hippocampus,
LFPs
cortex.
Thus,
lack
reduces
oscillatory
LFP
specific
brain
regions,
despite
affecting
oscillations.
Together,
our
findings
reveal
reduced
cross-frequency
as
functional
marker
deficiency
Nature Communications,
Год журнала:
2018,
Номер
10(1)
Опубликована: Дек. 28, 2018
CRISPR/Cas9
guided
gene-editing
is
a
potential
therapeutic
tool,
however
application
to
neurodegenerative
disease
models
has
been
limited.
Moreover,
conventional
mutation
correction
by
would
only
be
relevant
for
the
small
fraction
of
cases
that
are
inherited.
Here
we
introduce
CRISPR/Cas9-based
strategy
in
cell
and
animal
edit
endogenous
amyloid
precursor
protein
(APP)
at
extreme
C-terminus
reciprocally
manipulate
pathway,
attenuating
APP-β-cleavage
Aβ
production,
while
up-regulating
neuroprotective
APP-α-cleavage.
APP
N-terminus
compensatory
APP-homologues
remain
intact,
with
no
apparent
effects
on
neurophysiology
vitro.
Robust
APP-editing
seen
human
iPSC-derived
neurons
mouse
brains
detectable
off-target
effects.
Our
likely
works
limiting
BACE-1
approximation,
also
delineate
mechanistic
events
abrogates
APP/BACE-1
convergence
this
setting.
work
offers
conceptual
proof
selective
silencing
strategy.
International Journal of Molecular Sciences,
Год журнала:
2015,
Номер
16(11), С. 26417 - 26451
Опубликована: Ноя. 4, 2015
Alzheimer’s
disease
(AD)
is
the
most
common
form
of
dementia.
The
risk
AD
increases
with
age.
Although
two
main
pathological
features
AD,
amyloid
plaques
and
neurofibrillary
tangles,
were
already
recognized
by
Alois
Alzheimer
at
beginning
20th
century,
pathogenesis
remains
unsettled.
Therapeutic
approaches
targeting
or
tangles
have
not
yet
resulted
in
satisfactory
improvements
treatment.
This
may,
part,
be
due
to
early-onset
late-onset
being
underpinned
different
mechanisms.
Most
animal
models
are
generated
from
gene
mutations
involved
early
onset
familial
accounting
for
only
1%
all
cases,
which
may
consequently
complicate
our
understanding
In
this
article,
authors
discuss
according
neuropathologies,
including
senescence-related
mechanisms
possible
treatments
using
stem
cells,
namely
mesenchymal
neural
cells.
African Health Sciences,
Год журнала:
2017,
Номер
16(4), С. 1045 - 1045
Опубликована: Март 7, 2017
Background:
Alzheimer's
disease
has
a
destructive
drawbacks
on
the
patient
and
his/her
entire
family
as
this
badly
affects
behavior,
cognition
abilities
to
do
activities
of
daily
living
(ADL).
The
physical
mental
benefits
exercise
are
widely
known
but
seldom
available
persons
suffering
from
disease.Objective:
aim
study
was
measure
quality
life,
systemic
inflammation
psychological
well-being
response
aerobic
exercises
in
Alzheimer's.Methods:
Forty
Alzheimer
elderly
subjects
were
enrolled
two
groups;
first
group
received
treadmill
exercise,
while
second
considered
control
no
training
intervention
for
months.
Assessment
tumor
necrosis
factor-alpha
(TNF-α),
interleukin-6
(IL-6),
Rosenberg
Self-Esteem
Scale
(RSES),Beck
Depression
Inventory
(BDI),
Profile
Mood
States(POMS)
SF-36
health
life
(SF-36
HRQL)
taken
before
at
end
study.Results:
There
25.2%,
19.4%,
23.5%,
21.3%,
17.7%
,
11.7%,
12.5%
10.1
%
reduction
mean
values
TNF-α,
IL-6,
BDI,
POMS,
transition
subscale,
bodily
pain
role
functioning:
emotional
subscale
respectively
addition
15.7%,
13.1%,
12.6%,
11.1%,
13.2%
11.2
increase
RSES,
functioning
functioning:physical
general
Vitality
Social
(A)
training,
so
that
there
significant
BDI
&
POMS
HRQL
scores,
RSES
result
results
(B)
who
not
significant.
Also,
differences
between
levels
investigated
parameters
(P<0.05).Conclusion:
Treadmill
walking
is
an
effective
treatment
policy
improve
wellbeing
Alzheimer's.Keywords:
Aerobic
well-being,
inflammation,