Exercise and mental health

Maturitas, Год журнала: 2017, Номер 106, С. 48 - 56

Опубликована: Сен. 8, 2017

Язык: Английский

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Exercise suppresses neuroinflammation for alleviating Alzheimer’s disease

Journal of Neuroinflammation, Год журнала: 2023, Номер 20(1)

Опубликована: Март 19, 2023

Abstract Alzheimer’s disease (AD) is a chronic neurodegenerative disease, with the characteristics of neurofibrillary tangle (NFT) and senile plaque (SP) formation. Although great progresses have been made in clinical trials based on relevant hypotheses, these studies are also accompanied by emergence toxic side effects, it an urgent task to explore underlying mechanisms for benefits prevent treat AD. Herein, animal experiments few trials, neuroinflammation AD characterized long-term activation pro-inflammatory microglia NOD-, LRR- pyrin domain-containing protein 3 (NLRP3) inflammasomes. Damaged signals from periphery within brain continuously activate microglia, thus resulting constant source inflammatory responses. The response exacerbates endoplasmic reticulum oxidative stress which triggers microglia-dependent immune responses, ultimately leading occurrence deterioration In this review, we systematically summarized sorted out that exercise ameliorates directly indirectly regulating central nervous system promoting hippocampal neurogenesis provide new direction exploring activity

Язык: Английский

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Physical Activity Improves Cognition and Activities of Daily Living in Adults with Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(3), С. 1216 - 1216

Опубликована: Янв. 22, 2022

Objective: The purpose of this meta-analysis was to examine the effects physical activity (PA) on cognition and activities daily living in adults with Alzheimer’s Disease (AD). Methods: Six electronic databases (MEDLINE, CINAHL, PsycArticles, SPORTDiscus, EMBASE CNKI) were used search for potential studies from inception until October 2021. Randomized controlled trials (RCTs) investigating effect AD patients compared a control condition included. sizes synthesized using random model 95% confidence interval (CI). Results: Sixteen articles including 945 participants (aged 70 88 years, 34.6% male) met inclusion criteria. pooled demonstrated that PA intervention associated significant improvements global (Standard Mean Difference (SMD) = 0.41, CI [0.24, 0.58], p < 0.01) (SMD 0.56, [0.32, 0.79], patients. Subgroup analyses suggested 3–4 times per week 30–45 min more than 12 weeks had relatively strong improving sensitivity analysis showed robust results. Conclusions: findings current can improve their Activities Daily Living (ADL) through engaging aerobic mixed exercise (aerobic anaerobic exercise).

Язык: Английский

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Exercise therapy to prevent and treat Alzheimer’s disease

Frontiers in Aging Neuroscience, Год журнала: 2023, Номер 15

Опубликована: Авг. 4, 2023

Alzheimer’s disease (AD) is a progressive neurodegenerative in the elderly with dementia, memory loss, and severe cognitive impairment that imposes high medical costs on individuals. The causes of AD include increased deposition amyloid beta (Aβ) phosphorylated tau, age, mitochondrial defects, neuroinflammation, decreased synaptic connections, nerve growth factors (NGF). While animals moderate-intensity exercise restores hippocampal amygdala through levels p-AKT, p-TrkB, p-PKC Aβ, tau phosphorylation, precursor proteins (APP) AD. Aerobic (with an intensity 50–75% VO2 max) prevents volume reduction, spatial learning reduction increasing flexibility. Exercise training induces binding brain-derived neurotrophic factor (BDNF) to TrkB NGF TrkA induce cell survival neuronal plasticity. After aerobic high-intensity interval training, increase VEGF, angiopoietin 1 2, NO, tPA, HCAR1 cerebral vessels blood flow angiogenesis cerebellum, motor cortex, striatum, hippocampus. In hippocampus, decreases fragmentation, DRP1, FIS1, improving OPA1, MFN1, MFN2, morphology. humans, acute as anti-inflammatory condition IL-6 such IL-1RA IL-10. Moderate-intensity also inhibits inflammatory markers IFN-γ, IL-1β, IL-6, CRP, TNF-α, sTNFR1, COX-2, NF-κB. significantly increases plasma BDNF, factor, plasticity, activity, memory, exploratory behavior subjects. Irisin myokine released from skeletal muscle during protects hippocampus by suppressing Aβ accumulation promoting proliferation STAT3 signaling. Therefore, combined strength balance coordination social activities seems provide important benefits for people

Язык: Английский

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Exercise mimetics: a novel strategy to combat neuroinflammation and Alzheimer’s disease

Journal of Neuroinflammation, Год журнала: 2024, Номер 21(1)

Опубликована: Фев. 2, 2024

Abstract Neuroinflammation is a pathological hallmark of Alzheimer’s disease (AD), characterized by the stimulation resident immune cells brain and penetration peripheral cells. These inflammatory processes facilitate deposition amyloid-beta (Aβ) plaques abnormal hyperphosphorylation tau protein. Managing neuroinflammation to restore homeostasis decrease neuronal damage therapeutic approach for AD. One way achieve this through exercise, which can improve function protect against neuroinflammation, oxidative stress, synaptic dysfunction in AD models. The neuroprotective impact exercise regulated various molecular factors that be activated same as administration their mimetics. Recent evidence has proven some mimetics effective alleviating AD, and, additionally, they are helpful alternative option patients who unable perform regular physical manage neurodegenerative disorders. This review focuses on current state knowledge mimetics, including efficacy, regulatory mechanisms, progress, challenges, limitations, future guidance application therapy.

Язык: Английский

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Effects of aerobic exercise on cognitive function and quality of life in patients with Alzheimer’s disease: a systematic review and meta-analysis

BMJ Open, Год журнала: 2025, Номер 15(1), С. e090623 - e090623

Опубликована: Янв. 1, 2025

Objectives Numerous studies have examined the effects of physical activity on cognitive performance and executive function in people with Alzheimer’s disease (AD), although findings are not entirely consistent. There also insufficient study reviews for specific workout assessment tool types. Therefore, purpose this was to systematically investigate aerobic exercise quality life, depressive symptoms AD. Design Risk bias assessed using Cochrane risk tool, systematic meta-analyses random-effects modelling, certainty evidence Grading Recommendations Assessment, Development Evaluation tool. Data sources PubMed, Web Science, Library, EMBASE, Scopus, CINAHL CNKI through 12 March 2024. Eligibility criteria The analysis includes all randomised controlled trials (RCTs) that used as an intervention individuals extraction synthesis Two writers selected searched data defined techniques. To possible heterogeneity between studies, meta-regression carried out Stata MP V.18.0 V.14.0 software, standardised mean differences (SMDs) 95% CIs were computed, reviewed Review Manager V.5.4 which made available by Collaboration. Sensitivity analyses employed ascertain stability reliability results, funnel plots Egger’s test check publication bias. Correction done Duval Tweedie clipping methods. Results Aerobic enhanced function. For Minimum Mental State Examination (MMSE) (SMD=0.95, CI 0.58 1.32, Z=5.06, p<0.00001), Disease Assessment Scale-Cognitive Section (ADAS-cog) (SMD=−0.67, −1.15 –0.2, Z=2.77, p=0.006) life (SMD=0.36, 0.08 0.64, Z=2.51, p=0.01), but statistically significant (SMD=−0.25, −0.63 0.13, Z=1.27, p=0.21). Subgroup showed duration greater than 16 weeks less 50 min per improved MMSE Scores. Duration more 30 ADAS-cog Scores patients weeks, three interventions week 30–50 improves Conclusion revealed conducive improvement among AD, yet it did exert a impact amelioration symptoms. Nevertheless, given high level variations included conclusions require further verification scientifically objective RCTs. PROSPERO registration number CRD42024526067

Язык: Английский

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Effects of Exergaming in People with Dementia: Results of a Systematic Literature Review

Journal of Alzheimer s Disease, Год журнала: 2018, Номер 63(2), С. 741 - 760

Опубликована: Апрель 17, 2018

Physical exercise benefits functioning, health, and well-being. However, people living with dementia in particular hardly engage exercise. Exergaming (exercise gaming) is an innovative, fun, relatively safe way of exercising a virtual reality or gaming environment. It may help overcome barriers they can experience regarding regular activities.This systematic literature review aims to provide overview the cost-effectiveness exergaming its effects on physical, cognitive, emotional, social as well quality life dementia.PubMed, Embase, Cinahl, PsycINFO, Cochrane Library, Web Science Core Collection were searched. Selection studies was carried out by at least two independent researchers.Three found be eligible included this review. Two these showed some statistically significant emotional functioning dementia, although based very small sample. No articles about exergaming.Only few controlled have been conducted into effectiveness exergaming, show little benefits. More well-designed are necessary examine exergaming.

Язык: Английский

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Comparative efficacy of interventions for reducing symptoms of depression in people with dementia: systematic review and network meta-analysis

BMJ, Год журнала: 2021, Номер unknown, С. n532 - n532

Опубликована: Март 24, 2021

Abstract Objective To describe the comparative efficacy of drug and non-drug interventions for reducing symptoms depression in people with dementia who experience as a neuropsychiatric symptom or have diagnosis major depressive disorder. Design Systematic review meta-analysis. Data sources Medline, Embase, Cochrane Library, CINAHL, PsycINFO, grey literature between inception 15 October 2020. Eligibility criteria study selection Randomised trials comparing usual care any other intervention targeting dementia. Main outcome measures Pairs reviewers screened studies, abstracted aggregate level data, appraised risk bias tool, which facilitated derivation standardised mean differences back transformed (on Cornell scale dementia) from bayesian random effects network meta-analyses pairwise meta-analyses. Results Of 22 138 citations screened, 256 studies (28 483 were included. Missing data posed greatest to findings. In meta-analysis including without disorder experiencing (213 studies; 25 177 dementia; variance 0.23), seven associated greater reduction compared care: cognitive stimulation (mean difference −2.93, 95% credible interval −4.35 −1.52), combined cholinesterase inhibitor (−11.39, −18.38 −3.93), massage touch therapy (−9.03, −12.28 −5.88), multidisciplinary (−1.98, −3.80 −0.16), occupational (−2.59, −4.70 −0.40), exercise social interaction (−12.37, −19.01 −5.36), reminiscence (−2.30, −3.68 −0.93). Except therapy, inhibitor, interaction, more efficacious than some interventions, no statistically significant was found Clinical methodological heterogeneity precluded specifically (22 1829 patients). Conclusions this systematic review, be registration PROSPERO CRD42017050130.

Язык: Английский

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Neurodegenerative Diseases: Implications of Environmental and Climatic Influences on Neurotransmitters and Neuronal Hormones Activities

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(19), С. 12495 - 12495

Опубликована: Сен. 30, 2022

Neurodegenerative and neuronal-related diseases are major public health concerns. Human vulnerability to neurodegenerative (NDDs) increases with age. Neuronal hormones neurotransmitters determinant factors regulating brain structure functions. The implications of environmental climatic changes emerged recently as influence on numerous diseases. However, the complex interaction neuronal their depletion under influences NDDs not well established in literature. In this review, we aim explore connection between highlight available potential therapeutic interventions that could use improve quality life reduce susceptibility NDDs.

Язык: Английский

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A systematic review of exercise modalities that reduce pro-inflammatory cytokines in humans and animals' models with mild cognitive impairment or dementia

Experimental Gerontology, Год журнала: 2023, Номер 175, С. 112141 - 112141

Опубликована: Март 14, 2023

To investigate which type, frequency, duration, intensity, and volume of chronic exercise might more strongly reduce pro-inflammatory cytokines enhance anti-inflammatory in human animal models with Mild Cognitive Impairment (MCI) or dementia.A systematic review.English-language search 13 electronic databases: Web Science, PubMed/Medline, Sport Discus, Scopus, Cochrane, Psych Net, Springer, ScienceDirect, Pascal & Francis, Sage journals, Pedro, Google Scholar, Sage.(i) studies that included exercise, physical activity, fitness training as an experimental intervention, (ii) addressed MCI, dementia, AD, (iii) focused on measuring and/or other inflammatory neuroinflammatory immune markers, examined indicators blood, CSF (Cerebrospinal Fluid), brain tissue.Of the 1290 found, 38 were for qualitative analysis, 11 articles, 25 two articles addressing both protocols. In model, decreased markers 70.8 % cytokines: IL -4, -10, IL-4β, -10β, TGF-β 26 articles. Treadmill running, resistance swimming increase cytokines. 53.9 items reduced proteins 23 increased proteins. Cycling multimodal, effectively cytokines.In rodent AD phenotype, treadmill, swimming, remain good interventions can delay various mechanisms dementia progression. aerobic, are beneficial MCI AD. Multimodal moderate to high intensity multimodal is effective MCI. Voluntary cycling training, moderate- high-intensity aerobic mild patients.

Язык: Английский

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