Cold Spring Harbor Perspectives in Biology,
Год журнала:
2013,
Номер
5(12), С. a017764 - a017764
Опубликована: Дек. 1, 2013
Douglas
L.
Chalker1,
Eric
Meyer2
and
Kazufumi
Mochizuki3
1Department
of
Biology,
Washington
University,
St.
Louis,
Missouri
63130
2Institut
de
Biologie
l'Ecole
Normale
Suprieure,
CNRS
UMR8197–
INSERM
U1024,
75005
Paris,
France
3Institute
Molecular
Biotechnology
the
Austrian
Academy
Sciences
(IMBA),
A-1030
Vienna,
Austria
Correspondence:
dchalker{at}biology2.wustl.edu
Cold Spring Harbor Perspectives in Biology,
Год журнала:
2014,
Номер
6(2), С. a018382 - a018382
Опубликована: Фев. 1, 2014
Denise
P.
Barlow1
and
Marisa
S.
Bartolomei2
1CeMM
Research
Center
for
Molecular
Medicine
of
the
Austrian
Academy
Sciences,
CeMM,
1090
Vienna,
Austria
2Department
Cell
Developmental
Biology,
University
Pennsylvania
Perelman
School
Medicine,
Philadelphia,
19104-6148
Correspondence:
dbarlow{at}cemm.oeaw.ac.at
bartolom{at}mail.med.upenn.edu
Cold Spring Harbor Perspectives in Biology,
Год журнала:
2014,
Номер
6(12), С. a019315 - a019315
Опубликована: Дек. 1, 2014
Craig
S.
Pikaard1
and
Ortrun
Mittelsten
Scheid2
1Department
of
Biology,
Department
Molecular
Cellular
Biochemistry,
Howard
Hughes
Medical
Institute,
Indiana
University,
Bloomington,
47405
2Gregor
Mendel-Institute
Plant
Austrian
Academy
Sciences,
1030
Vienna,
Austria
Correspondence:
ortrun.mittelsten_scheid{at}gmi.oeaw.ac.at
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Май 13, 2023
Abstract
Infection
susceptibility,
poor
vaccination
efficacy,
age-related
disease
onset,
and
neoplasms
are
linked
to
innate
adaptive
immune
dysfunction
that
accompanies
aging
(known
as
immunosenescence).
During
aging,
organisms
tend
develop
a
characteristic
inflammatory
state
expresses
high
levels
of
pro-inflammatory
markers,
termed
inflammaging.
This
chronic
inflammation
is
typical
phenomenon
immunosenescence
it
considered
the
major
risk
factor
for
diseases.
Thymic
involution,
naïve/memory
cell
ratio
imbalance,
dysregulated
metabolism,
epigenetic
alterations
striking
features
immunosenescence.
Disturbed
T-cell
pools
antigen
stimulation
mediate
premature
senescence
cells,
senescent
cells
proinflammatory
senescence-associated
secretory
phenotype
exacerbates
Although
underlying
molecular
mechanisms
remain
be
addressed,
well
documented
T
inflammaging
might
driving
forces
in
Potential
counteractive
measures
will
discussed,
including
intervention
cellular
metabolic-epigenetic
axes
mitigate
In
recent
years,
has
attracted
increasing
attention
its
role
tumor
development.
As
result
limited
participation
elderly
patients,
impact
on
cancer
immunotherapy
unclear.
Despite
some
surprising
results
from
clinical
trials
drugs,
necessary
investigate
other
Cold Spring Harbor Perspectives in Biology,
Год журнала:
2013,
Номер
5(9), С. a017905 - a017905
Опубликована: Сен. 1, 2013
Peter
B.
Becker1
and
Jerry
L.
Workman2
1BioMedical
Center,
Ludwig-Maximilians-University,
D-80336
Munich,
Germany
2Stowers
Institute
for
Medical
Research,
Kansas
City,
Missouri
64110
Correspondence:
pbecker{at}med.uni-muenchen.de;
jlw{at}stowers.org
Reproduction,
Год журнала:
2016,
Номер
151(5), С. R55 - R70
Опубликована: Апрель 29, 2016
Abstract
In
mammals,
male
germ
cells
differentiate
from
haploid
round
spermatids
to
flagella-containing
motile
sperm
in
a
process
called
spermiogenesis.
This
is
distinct
somatic
cell
differentiation
that
the
majority
of
core
histones
are
replaced
sequentially,
first
by
transition
proteins
and
then
protamines,
facilitating
chromatin
hyper-compaction.
histone-to-protamine
represents
an
excellent
model
for
investigation
how
epigenetic
regulators
interact
with
each
other
remodel
architecture.
Although
early
work
field
highlighted
critical
roles
testis-specific
transcription
factors
controlling
haploid-specific
developmental
program,
recent
studies
underscore
essential
functions
players
involved
dramatic
genome
remodeling
takes
place
during
wholesale
histone
replacement.
this
review,
we
discuss
advances
our
understanding
players,
such
as
variants
writers/readers/erasers,
rewire
spermatid
facilitate
substitution
protamines
mammals.
Cold Spring Harbor Perspectives in Biology,
Год журнала:
2015,
Номер
7(5), С. a019398 - a019398
Опубликована: Май 1, 2015
John
C.
Lucchesi1
and
Mitzi
I.
Kuroda2
1Department
of
Biology,
O.
W.
Rollins
Research
Center,
Emory
University,
Atlanta,
Georgia
30322
2Department
Genetics,
Harvard
Medical
School,
Boston,
Massachusetts
02115
Correspondence:
jclucch{at}emory.edu
Proceedings of the National Academy of Sciences,
Год журнала:
2019,
Номер
116(18), С. 9030 - 9039
Опубликована: Март 25, 2019
Cellular
senescence
is
a
form
of
adaptive
cellular
physiology
associated
with
aging.
causes
proinflammatory
phenotype
that
impairs
tissue
regeneration,
has
been
linked
to
stress,
and
implicated
in
several
human
neurodegenerative
diseases.
We
had
previously
determined
neural
progenitor
cells
(NPCs)
derived
from
induced
pluripotent
stem
cell
(iPSC)
lines
patients
primary
progressive
multiple
sclerosis
(PPMS)
failed
promote
oligodendrocyte
(OPC)
maturation,
whereas
NPCs
age-matched
control
did
so
efficiently.
Herein,
we
report
expression
hallmarks
were
identified
SOX2
+
within
white
matter
lesions
MS
(PMS)
autopsy
brain
tissues
iPS-derived
PPMS.
Expression
genes
PPMS
was
found
be
reversible
by
treatment
rapamycin,
which
then
enhanced
NPC
support
for
(OL)
differentiation.
A
proteomic
analysis
the
secretome
high-mobility
group
box-1
(HMGB1),
senescence-associated
inhibitor
OL
Transcriptome
OPCs
revealed
senescent
epigenetic
regulators
mediated
extracellular
HMGB1.
Lastly,
are
source
elevated
HMGB1
lesions.
Based
on
these
data,
conclude
contributes
altered
functions
demyelinated
MS.
Moreover,
data
implicate
aging
as
process
remyelination
failure
PMS,
may
impact
how
this
disease
modeled
inform
development
future
myelin
regeneration
strategies.
