Molecules,
Год журнала:
2021,
Номер
26(15), С. 4535 - 4535
Опубликована: Июль 27, 2021
Limonene
is
a
monoterpene
confined
to
the
family
of
Rutaceae,
showing
several
biological
properties
such
as
antioxidant,
anti-inflammatory,
anticancer,
antinociceptive
and
gastroprotective
characteristics.
Recently,
there
notable
interest
in
investigating
pharmacological
effects
limonene
various
chronic
diseases
due
its
mitigating
effect
on
oxidative
stress
inflammation
regulating
apoptotic
cell
death.
There
are
available
studies
demonstrating
neuroprotective
role
neurodegenerative
diseases,
including
Alzheimer’s
disease,
multiple
sclerosis,
epilepsy,
anxiety,
stroke.
The
high
abundance
nature,
safety
profile,
mechanisms
action
make
this
favorable
molecule
be
developed
nutraceutical
for
preventive
purposes
an
alternative
agent
or
adjuvant
modern
therapeutic
drugs
curbing
onset
progression
diseases.
This
manuscript
presents
comprehensive
review
scientific
literature
discussing
activities
plant
products
containing
which
attribute
protective
ability
disorders.
has
been
compiled
based
existing
published
articles
limonene-containing
natural
investigated
their
neurotherapeutic
potential.
All
English
abstract
were
extracted
from
different
databases
that
offer
access
diverse
journals.
These
PubMed,
Scopus,
Google
Scholar,
Science
Direct.
Collectively,
emphasizes
potential
against
other
neuroinflammatory
data
indicative
nutritional
use
actions
may
direct
future
preclinical
clinical
development
complementary
phytomedicine.
pharmacophore
can
also
provide
blueprint
further
drug
discovery
using
numerous
tools.
Nature Communications,
Год журнала:
2019,
Номер
10(1)
Опубликована: Май 15, 2019
Abstract
Neuropathologists
assess
vast
brain
areas
to
identify
diverse
and
subtly-differentiated
morphologies.
Standard
semi-quantitative
scoring
approaches,
however,
are
coarse-grained
lack
precise
neuroanatomic
localization.
We
report
a
proof-of-concept
deep
learning
pipeline
that
identifies
specific
neuropathologies—amyloid
plaques
cerebral
amyloid
angiopathy—in
immunohistochemically-stained
archival
slides.
Using
automated
segmentation
of
stained
objects
cloud-based
interface,
we
annotate
>
70,000
plaque
candidates
from
43
whole
slide
images
(WSIs)
train
evaluate
convolutional
neural
networks.
Networks
achieve
strong
classification
on
10-WSI
hold-out
set
(0.993
0.743
under
the
receiver
operating
characteristic
precision
recall
curve,
respectively).
Prediction
confidence
maps
visualize
morphology
distributions
at
high
resolution.
Resulting
network-derived
beta
(Aβ)-burden
scores
correlate
well
with
established
30-WSI
blinded
hold-out.
Finally,
saliency
mapping
demonstrates
networks
learn
patterns
agreeing
accepted
pathologic
features.
This
scalable
means
augment
neuropathologist’s
ability
suggests
route
neuropathologic
phenotyping.
Molecular Neurodegeneration,
Год журнала:
2022,
Номер
17(1)
Опубликована: Апрель 7, 2022
Abstract
Background
Tauopathies
are
a
class
of
neurodegenerative
disorders
characterized
by
neuronal
and/or
glial
tau-positive
inclusions.
Main
body
Clinically,
tauopathies
can
present
with
range
phenotypes
that
include
cognitive/behavioral-disorders,
movement
disorders,
language
and
non-specific
amnestic
symptoms
in
advanced
age.
Pathologically,
be
classified
based
on
the
predominant
tau
isoforms
inclusion
bodies
(i.e.,
3R,
4R
or
equal
3R:4R
ratio).
Imaging,
cerebrospinal
fluid
(CSF)
blood-based
biomarkers
have
potential
to
used
as
routine
diagnostic
strategy
evaluation
patients
tauopathies.
As
strongly
linked
neuropathologically
genetically
protein
abnormalities,
there
is
growing
interest
pursuing
tau-directed
therapeutics
for
disorders.
Here
we
synthesize
emerging
lessons
from
clinical,
pathological,
genetic,
experimental
studies
toward
unified
concept
these
may
accelerate
therapeutics.
Conclusions
Since
still
untreatable
diseases,
efforts
been
made
depict
clinical
pathological
characteristics,
identify
biomarkers,
elucidate
underlying
pathogenesis
achieve
early
diagnosis
develop
disease-modifying
therapies.
Antioxidants,
Год журнала:
2020,
Номер
9(7), С. 609 - 609
Опубликована: Июль 10, 2020
Neurodegenerative
disorders
have
emerged
as
a
serious
health
issue
in
the
current
era.
The
most
common
neurodegenerative
are
Alzheimer’s
disease
(AD),
Parkinson’s
disease,
multiple
sclerosis,
and
amyotrophic
lateral
sclerosis
(ALS).
These
diseases
involve
progressive
impairment
of
neurodegeneration
memory
impairment.
A
wide
range
compounds
been
identified
potential
neuroprotective
agents
against
different
models
both
vivo
vitro.
Hesperetin,
flavanone
class
citrus
flavonoid,
is
derivative
hesperidin
found
fruits
such
oranges,
grapes,
lemons.
It
has
extensively
reported
that
hesperetin
exerts
effects
experimental
diseases.
In
this
systematic
review,
we
compiled
all
studies
conducted
on
vitro
neurodegeneration.
Here,
used
an
approach
to
lessen
bias
each
study,
providing
least
biased,
broad
understanding
findings
impartial
conclusions
strength
evidence
reliability
findings.
collected
papers
from
journals
describing
beneficial
animal
Our
results
demonstrated
consistent
addition,
summarized
its
underlying
mechanisms.
This
study
provides
foundations
for
future
recommendations
further
mechanistic
approaches
conduct
preclinical
models.
BioFactors,
Год журнала:
2019,
Номер
46(1), С. 5 - 20
Опубликована: Окт. 3, 2019
Abstract
Neurodegenerative
diseases
(NDs)
result
from
progressive
deterioration
of
selectively
susceptible
neuron
populations
in
different
central
nervous
system
(CNS)
regions.
NDs
are
classified
accordance
with
the
primary
clinical
manifestations
(e.g.,
parkinsonism,
dementia,
or
motor
disease),
anatomic
basis
neurodegeneration
frontotemporal
degenerations,
extrapyramidal
disorders,
spinocerebellar
degenerations),
and
fundamental
molecular
abnormalities
mutations,
mitochondrial
dysfunction,
its
related
alterations).
include
Alzheimer
disease
Parkinson
disease,
among
others.
There
is
a
growing
evidence
that
dysfunction
mutations
form
oxidative/nitrosative
stress
neurotoxic
compounds
play
major
roles
pathogenesis
various
NDs.
Curcumin,
polyphenol
nontoxic
compound,
obtained
turmeric,
has
been
shown
to
have
therapeutic
beneficial
effect
disorders
especially
on
CNS
cells.
It
curcumin
considerable
neuro‐
mitochondria‐protective
properties
against
broad‐spectrum
diseases/injury‐associating
In
this
article,
we
reviewed
effects
Biomedicines,
Год журнала:
2021,
Номер
9(7), С. 791 - 791
Опубликована: Июль 8, 2021
The
spliced
form
of
X-box
binding
protein
1
(XBP1s)
is
an
active
transcription
factor
that
plays
a
vital
role
in
the
unfolded
response
(UPR).
Under
endoplasmic
reticulum
(ER)
stress,
unspliced
Xbp1
mRNA
cleaved
by
activated
stress
sensor
IRE1α
and
converted
to
mature
encoding
XBP1
(XBP1s).
Translated
XBP1s
migrates
nucleus
regulates
transcriptional
programs
UPR
target
genes
ER
molecular
chaperones,
folding
enzymes,
ER-associated
degradation
(ERAD)
components
decrease
stress.
Moreover,
studies
have
shown
diverse
are
involved
lipid
glucose
metabolism
immune
responses.
Therefore,
has
been
considered
important
therapeutic
studying
various
diseases,
including
cancer,
diabetes,
autoimmune
inflammatory
diseases.
several
unique
mechanisms
regulate
different
interacting
with
other
proteins
modulate
their
activity.
Although
recent
discovered
numerous
via
genome-wide
analyses,
how
remains
unclear.
This
review
discusses
roles
regulation.
More
in-depth
knowledge
regulatory
future
will
help
develop
new
targets
for
each
disease.
Progress in Neurobiology,
Год журнала:
2022,
Номер
214, С. 102270 - 102270
Опубликована: Апрель 18, 2022
Aggregation
of
specific
proteins
are
histopathological
hallmarks
several
neurodegenerative
diseases,
such
as,
Amyloid
β
(Aβ)
plaques
and
tau
neurofibrillary
tangles
in
Alzheimer's
disease
(AD);
morphologically
different
inclusions
ratiometric
3
repeat
(3
R)
4
(4
isoforms
progressive
supranuclear
palsy
(PSP),
corticobasal
degeneration
(CBD),
Pick's
(PiD);
α-Synuclein
(α-Syn)
containing
Lewy
bodies
(LBs)
dystrophic
neurites
(LNs)
Parkinson's
(PD)
dementia
with
(DLB).
However,
mixed
brain
protein
pathologies
have
been
frequently
observed
many
these
diseases
normal
aging
brains,
among
which
Aβ/tau
tau/α-Syn
crosstalks
received
increased
attention.
Interestingly,
studies
also
shown
synergistic
interplay
Aβ,
tau,
α-Syn
suggesting
a
triumvirate.
In
this
review,
we
summarize
the
emerging
evidence
aggregation
pathophysiology,
their
overlap
spectrum
including
AD,
PSP,
PiD,
CBD,
PD
DLB.
We
discuss
prognostic
advancements
made
biomarker
imaging
techniques
triumvirate
proteinopathies.
Finally,
combined
therapeutic
modality
involving
biomarkers
for
future
combinatorial
immunotherapeutic
targeting
more
than
one
aggregates.
hope
that
multitarget
approach
will
or
additive
effects
to
manage
two
might
uncover
promising
strategy
personalized
combination
therapies.
Managing
by
optimizing
diagnostic
criteria
correct
immunotherapies
be
key
factor
success
treatment.