LncRNA MAGI2-AS3-Encoded Polypeptide Restrains the Proliferation and Migration of Breast Cancer Cells

Molecular Biotechnology, Год журнала: 2023, Номер 66(6), С. 1409 - 1423

Опубликована: Июнь 26, 2023

Язык: Английский

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Type 3 IP3 receptors: The chameleon in cancer

International review of cell and molecular biology, Год журнала: 2020, Номер unknown, С. 101 - 148

Опубликована: Янв. 1, 2020

Язык: Английский

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Towards an integrative understanding of cancer mechanobiology: calcium, YAP, and microRNA under biophysical forces

Soft Matter, Год журнала: 2022, Номер 18(6), С. 1112 - 1148

Опубликована: Янв. 1, 2022

Increasingly the significant roles of interplay between tissue microenvironmental mechanics and cellular biochemical activities during tumor progression have been demonstrated, providing insights into development novel cancer therapies.

Язык: Английский

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The Underexplored Landscape of Hypoxia-Inducible Factor 2 Alpha and Potential Roles in Tumor Macrophages: A Review

Oxygen, Год журнала: 2023, Номер 3(1), С. 45 - 76

Опубликована: Янв. 31, 2023

Low tissue oxygenation, termed

Язык: Английский

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Advances in Nanotherapeutics for Tumor Treatment by Targeting Calcium Overload

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 245, С. 114190 - 114190

Опубликована: Сен. 2, 2024

Язык: Английский

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Calcium signaling: breast cancer’s approach to manipulation of cellular circuitry

Biophysical Reviews, Год журнала: 2020, Номер 12(6), С. 1343 - 1359

Опубликована: Дек. 1, 2020

Calcium is a versatile element that participates in cell signaling for wide range of processes such as death, cycle, division, migration, invasion, metabolism, differentiation, autophagy, transcription, and others. Specificity calcium each these achieved through modulation intracellular concentrations by changing the characteristics (amplitude/frequency modulation) or location (spatial signal. Breast cancer utilizes an advantage survival progression. This review integrates evidence showing increases expression channels, GPCRs, pumps, effectors, enzymes, well resulting signals, lead to high and/or elevated calcium- mobilizing capacity necessary malignant functions migratory, invasive, proliferative, tumorigenic, metastatic capacities.

Язык: Английский

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The ER-mitochondria Ca2+ signaling in cancer progression: Fueling the monster

International review of cell and molecular biology, Год журнала: 2021, Номер unknown, С. 49 - 121

Опубликована: Янв. 1, 2021

Язык: Английский

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Tepary Bean (Phaseolus acutifolius) Lectins as Modulators of Intracellular Calcium Mobilization in Breast Cancer and Normal Breast Cells

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1064 - 1064

Опубликована: Янв. 26, 2025

Lectins are proteins that specifically recognize carbohydrates on cell membranes, triggering several cellular events such as apoptosis of cancer-transformed cells; however, the mechanisms action remain incompletely understood. Our research group has reported a concentrated fraction Tepary bean lectins (Phaseolus acutifolius; TBLF) exhibits concentration-dependent induction in colon cancer cells by caspase activation. It is well established an increase cytoplasmic calcium ([Ca2+]i) initiates intracellular signals involved processes exocytosis, gene transcription, apoptosis, cycle regulation, and muscle contraction, among others. Furthermore, dysregulated signaling been implicated various diseases, including certain neurological disorders cancer. In this study, we aim to demonstrate effects native TBLF recombinant lectin (rTBL-1) mobility breast (MCF-7) non-cancerous (MCF-12F). Both rTBL-1 increased concentrations mobilized from stores manner; two lines exhibited differential responses. While MCF-12F restored concentration, MCF-7 maintained high concentration. This strongly suggests can elicit responses non-cancer due variations their intrinsic homeostasis. Finally, demonstrated differentially alter Metabolic Cellular Activity (MCA) direct measure viability (CVi) both lines. These findings strengthen evidence therapeutic potential lectins. Undoubtedly, further studies will be necessary elucidate underlying applications.

Язык: Английский

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Orchestrating Intracellular Calcium Signaling Cascades by Phosphosite-Centric Regulatory Network: A Comprehensive Analysis on Kinases CAMKK1 and CAMKK2

OMICS A Journal of Integrative Biology, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Intracellular calcium signaling is a cornerstone in cell biology and key molecular target for human health disease. Calcium/calmodulin dependent protein kinase kinases, CAMKK1 CAMKK2 are serine/threonine kinases that contribute to the regulation of intracellular signals response diverse stimuli. generally has stable dynamics, whereas dysregulation triggers oncogenicity neurological disorders. To differentiate phosphosignaling hierarchy associated with predominant phosphosites CAMKK2, we assembled analyzed global cellular phosphoproteome datasets. We found located outside domain, their phosphomotifs highly homologous. Further, employed coregulation analysis approach these phosphosites, infer co-occurrence patterns phosphorylations within CAMKKs other CAMKK sites. report herein independent at S100 S511 increase enzymatic activity presence calcium/calmodulin. In addition, study unveils kinase-substrate associations such as RPS6KB1 novel high-confidence upstream both S74 S100. was identified primary orchestrator mediating cascades compared based on from proteins involved pathway. These details shed promising insights into pathophysiology several diseases cancers psychiatric disorders dysregulations further open avenue PTM-directed therapeutic strategies regulate CAMKK2.

Язык: Английский

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Insights into Sorafenib resistance in hepatocellular carcinoma: Mechanisms and therapeutic aspects.

Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер unknown, С. 104765 - 104765

Опубликована: Май 1, 2025

Язык: Английский

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