Opioid use and abuse in adolescents and young adults; dealing with science, laws and ethics: Charming the COBRAS

Disease-a-Month, Journal Year: 2025, Volume and Issue: unknown, P. 101853 - 101853

Published: Jan. 1, 2025

Language: Английский

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Trajectories of working memory and decision making abilities along juvenile development in mice

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 28, 2025

Rodents commonly serve as model organisms for the investigation of human mental disorders by capitalizing on behavioral commonalities. However, our understanding developmental dynamics complex cognitive abilities in rodents remains incomplete. In this study, we examined spatial working memory well odor-and texture-based decision making mice using a delayed non-match to sample task and two-choice set-shifting task, respectively. Mice were investigated during different stages development: pre-juvenile, juvenile, young adult age. We show that, while improve with age, performance peaks juvenile age showing sex-independent trajectory. Moreover, cFos expression, first proxy neuronal activity, shows distinct age-and brain area-specific changes that relate task-specific performance. The trajectories resemble those previously reported humans.

Language: Английский

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Characterizing Large-Scale Human Circuit Development with In Vivo Neuroimaging

Cold Spring Harbor Perspectives in Biology, Journal Year: 2024, Volume and Issue: 16(6), P. a041496 - a041496

Published: March 4, 2024

Tomoki Arichi1,2,3 1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London SE1 7EH, United Kingdom 2MRC Centre Neurodevelopmental Disorders, New Hunt's House, Guy's Campus, 1UL, 3Children's Neurosciences, Evelina Children's NHS Foundation Trust, Correspondence: tomoki.arichi{at}kcl.ac.uk

Language: Английский

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