Journal of Proteome Research,
Год журнала:
2010,
Номер
9(4), С. 2006 - 2015
Опубликована: Фев. 17, 2010
Neuropeptidomic
data
were
collected
on
the
mosquito
Ae.
aegypti,
which
is
considered
most
tractable
species
for
physiological
and
endocrine
studies.
The
solely
obtained
by
direct
mass
spectrometric
profiling,
including
tandem
fragmentation,
of
selected
tissues
from
single
specimens,
yielded
a
largely
complete
accounting
putative
bioactive
neuropeptides;
truncated
neuropeptides
with
low
abundance
not
counted
as
mature
peptides.
Differential
processing
within
CNS
was
detected
CAPA-precursor,
differential
post-translational
(pyroglutamate
formation)
AST-C
CAPA-PVK-2.
For
first
time
in
insects,
we
succeeded
profiling
midgut
tissue
comprehensive
immediate
overview
peptides
involved
system
gut.
Head
earlier
identified
abundant
RFamides
any
part
or
midgut.
This
study
provides
framework
future
investigations
endocrinology
neurobiology.
Given
high
sequence
similarity
neuropeptide
precursors
other
medically
important
mosquitoes,
conclusions
regarding
peptidome
aegypti
likely
are
applicable
to
these
mosquitoes.
Annual Review of Entomology,
Год журнала:
2017,
Номер
63(1), С. 489 - 511
Опубликована: Окт. 23, 2017
The
synthesis
of
vitellogenin
and
its
uptake
by
maturing
oocytes
during
egg
maturation
are
essential
for
successful
female
reproduction.
These
events
regulated
the
juvenile
hormones
ecdysteroids
nutritional
signaling
pathway
neuropeptides.
Juvenile
act
as
gonadotropins,
regulating
vitellogenesis
in
most
insects,
but
control
this
process
Diptera
some
Hymenoptera
Lepidoptera.
complex
crosstalk
between
hormones,
ecdysteroids,
pathways
differs
distinctly
depending
on
reproductive
strategies
adopted
various
insects.
Molecular
studies
within
past
decade
have
revealed
much
about
relationships
among,
role
of,
these
with
respect
to
regulation
insect
Here,
we
review
signaling,
along
that
microRNAs,
reproduction
at
molecular
level.
Proceedings of the National Academy of Sciences,
Год журнала:
2013,
Номер
110(21), С. 8702 - 8707
Опубликована: Май 1, 2013
Neuropeptides
are
signaling
molecules
that
commonly
act
via
G
protein-coupled
receptors
(GPCRs)
and
generated
in
neurons
by
proneuropeptide
(pNP)
cleavage.
Present
both
cnidarians
bilaterians,
neuropeptides
represent
an
ancient
widespread
mode
of
neuronal
communication.
Due
to
the
inherent
difficulties
analyzing
highly
diverse
repetitive
pNPs,
relationships
among
different
families
often
elusive.
Using
similarity-based
clustering
sensitive
similarity
searches,
I
obtained
a
global
view
metazoan
pNP
diversity
evolution.
Clustering
revealed
large
diffuse
network
sequences
connected
significant
sequence
encompassing
one-quarter
all
families.
pNPs
belonging
this
cluster
were
also
identified
early-branching
neuronless
animal
Trichoplax
adhaerens
.
neuropeptide
GPCRs
several
orthology
groups
allowed
reconstruction
phyletic
distribution
receptor
GPCR
closely
paralleled
indicating
extensive
conservation
long-term
coevolution
receptor–ligand
pairs.
Receptor
intermediate
homology
so
far
considered
unrelated,
including
allatotropin
orexin.
These
findings,
together
with
identification
deuterostome
achatin
luqin
protostome
opioid
extended
complement
urbilaterian.
Several
from
hemichordate
Saccoglossus
kowalevskii
cephalochordate
Branchiostoma
floridae,
elucidating
evolution
deuterostomes.
Receptor–ligand
ligand
predictions
for
many
uncharacterized
nonmodel
species.
The
neuropeptide-signaling
repertoire
at
deep
nodes
phylogeny
formulation
testable
scenario
neuroendocrine
systems.
PLoS Biology,
Год журнала:
2010,
Номер
8(10), С. e1000509 - e1000509
Опубликована: Окт. 12, 2010
Genomic/peptidomic
analyses
of
the
planarian
Schmidtea
mediterranea
identifies
>200
neuropeptides
and
uncovers
a
conserved
neuropeptide
required
for
proper
maturation
maintenance
reproductive
system.
Journal of Biological Chemistry,
Год журнала:
2011,
Номер
286(49), С. 41924 - 41936
Опубликована: Окт. 15, 2011
Our
recent
studies
identified
juvenile
hormone
(JH)
and
nutrition
as
the
two
key
signals
that
regulate
vitellogenin
(Vg)
gene
expression
in
red
flour
beetle,
Tribolium
castaneum.
Juvenile
regulation
of
Vg
synthesis
has
been
known
for
a
long
time
several
insects,
but
mechanism
JH
action
is
not
known.
Experiments
were
conducted
to
determine
these
expression.
Injection
bovine
insulin
or
FOXO
double-stranded
RNA
into
previtellogenic,
starved,
JH-deficient
female
adults
increased
mRNA
protein
levels,
thereby
implicating
pivotal
role
insulin-like
peptide
signaling
possible
cross-talk
between
pathways.
Reduction
its
by
RNAi-mediated
silencing
genes
coding
acid
methyltransferase
methoprene-tolerant
decreased
peptides
(ILPs)
influenced
subcellular
localization,
resulting
down-regulation
Furthermore,
application
previtellogenic
beetles
induced
ILP2
ILP3,
expressed
baculovirus
system
binds
response
element
present
promoter.
These
data
suggest
functions
through
pathway
