Drosophila neuropeptides in regulation of physiology and behavior

Progress in Neurobiology, Год журнала: 2010, Номер 92(1), С. 42 - 104

Опубликована: Май 5, 2010

Язык: Английский

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Genomic insights into the Ixodes scapularis tick vector of Lyme disease

Nature Communications, Год журнала: 2016, Номер 7(1)

Опубликована: Фев. 9, 2016

Abstract Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of tick, Ixodes scapularis (Say), which vectors that cause Lyme disease, human granulocytic anaplasmosis, babesiosis diseases. The large reflects accumulation repetitive DNA, new lineages retro-transposons, gene architecture patterns resembling ancient metazoans rather pancrustaceans. Annotation scaffolds representing ∼57% genome, reveals 20,486 protein-coding genes expansions families associated with tick–host interactions. report insights from analyses into parasitic processes unique ticks, including host ‘questing’, prolonged feeding, cuticle synthesis, blood meal concentration, novel methods haemoglobin digestion, haem detoxification, vitellogenesis off-host survival. identify proteins agent an emerging encephalitis-causing Langat virus, a population structure correlated life-history traits transmission disease agent.

Язык: Английский

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Molecular evolution of peptidergic signaling systems in bilaterians

Proceedings of the National Academy of Sciences, Год журнала: 2013, Номер 110(22)

Опубликована: Май 13, 2013

Significance Peptides and their specific receptors form molecular peptidergic systems (PSs) that are essential components of neuronal communication in the animal brain. Many PSs have been characterized insects mammals but precise evolutionary relationship is not fully understood. We interrogated genomic sequence databases used phylogenetic reconstruction tools to show a large fraction human were already present last common ancestor flies, mollusks, urchins, mammals. Our analysis provides comprehensive view will pave way for comparative studies leading better understanding physiology behavior.

Язык: Английский

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The genomes of two key bumblebee species with primitive eusocial organization

Genome Biology, Год журнала: 2015, Номер 16(1)

Опубликована: Апрель 13, 2015

The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed illuminate evolution highly insect societies. Bumblebees also invaluable natural and agricultural pollinators, there widespread concern over recent population declines in some species. High-quality genomic data will inform key aspects bumblebee biology, including susceptibility implicated viability threats.We report high quality draft genome sequences Bombus terrestris impatiens, two ecologically dominant widely utilized study Comparing these new genomes those honeybee Apis mellifera other Hymenoptera, we identify deeply conserved similarities, as well novelties biology organisms. Some features thought underpin advanced eusociality present bumblebees, indicating an earlier bee lineage. Xenobiotic detoxification immune genes similarly depauperate honeybees, multiple categories linked organization, development behavior, show conservation. Key differences identified include a bias chemoreception towards gustation olfaction, striking microRNAs, potentially responsible for gene regulation underlying traits.These provide foundation post-genomic research on pollinators Overall, repertoires suggest that route bees was mediated by many small changes processes, not notable expansion or depauperation.

Язык: Английский

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Genomic signatures of evolutionary transitions from solitary to group living

Science, Год журнала: 2015, Номер 348(6239), С. 1139 - 1143

Опубликована: Май 15, 2015

For bees, many roads lead to social harmony Eusociality, where workers sacrifice their reproductive rights support the colony, has evolved repeatedly and represents most form of evolution in insects. Kapheim et al. looked across genomes 10 bee species with varying degrees sociality determine underlying genomic contributions. No one path led eusociality, but similarities were seen features such as increases gene regulation methylation. It also seems that selection pressures relaxed after emergence complex sociality. Science , this issue p. 1139

Язык: Английский

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Genomics, transcriptomics, and peptidomics of neuropeptides and protein hormones in the red flour beetle Tribolium castaneum

Genome Research, Год журнала: 2007, Номер 18(1), С. 113 - 122

Опубликована: Ноя. 19, 2007

Neuropeptides and protein hormones are ancient molecules that mediate cell-to-cell communication. The whole genome sequence from the red flour beetle Tribolium castaneum , along with those other insect species, provides an opportunity to study evolution of genes encoding neuropeptide hormones. We identified 41 these in by using a combination bioinformatic peptidomic approaches. These encode >80 mature neuropeptides hormones, 49 peptides which were experimentally peptidomics central nervous system neuroendocrine organs. Twenty-three have orthologs Drosophila melanogaster : Sixteen five different groups likely result recent gene expansions during evolution. contain related antidiuretic factor-b (ADF-b), CRF-like diuretic hormone (DH37 DH47 ), adipokinetic (AKH), eclosion hormone, insulin-like peptide. In addition, we found arginine-vasopressin-like (AVPL) peptide one for its receptor. Both occur only not holometabolous insects sequenced genome. presence many additional osmoregulatory agrees well ability live very dry surroundings. contrast extra genes, there at least nine missing including prepropeptides corazonin, kinin, allatostatin-A. cognate receptor three also appear be absent Our analysis indicates that, evolution, often duplicated or lost.

Язык: Английский

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Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior

Progress in Neurobiology, Год журнала: 2019, Номер 179, С. 101607 - 101607

Опубликована: Март 22, 2019

Язык: Английский

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The First Myriapod Genome Sequence Reveals Conservative Arthropod Gene Content and Genome Organisation in the Centipede Strigamia maritima

PLoS Biology, Год журнала: 2014, Номер 12(11), С. e1002005 - e1002005

Опубликована: Ноя. 25, 2014

Myriapods (e.g., centipedes and millipedes) display a simple homonomous body plan relative to other arthropods. All members of the class are terrestrial, but they attained terrestriality independently insects. Myriapoda is only arthropod not represented by sequenced genome. We present an analysis genome centipede Strigamia maritima. It retains compact that has undergone less gene loss shuffling than previously arthropods, many orthologues genes conserved from bilaterian ancestor have been lost in Our locates macro-synteny contexts, small-scale examples clustering. describe several where S. maritima shows different solutions insects similar problems. The insect olfactory receptor family absent maritima, olfaction air likely effected expansion families. For some evolved paralogues generate coding sequence diversity, use alternate splicing. This most striking for Dscam gene, which Drosophila generates more 100,000 splice forms, encoded over 100 paralogues. see intriguing linkage between absence any known photosensory proteins blind organism additional canonical circadian clock genes. phylogenetic position myriapods allows us identify phylogeny particular molecular mechanisms traits emerged. example, we conclude juvenile hormone signalling with emergence exoskeleton arthropods RR-1 containing cuticle lineage leading Mandibulata. also when various expansions losses occurred. offers unique glimpse into ancestral genome, while displaying adaptations its specific life history.

Язык: Английский

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A comparative review of short and long neuropeptide F signaling in invertebrates: Any similarities to vertebrate neuropeptide Y signaling?

Peptides, Год журнала: 2011, Номер 32(6), С. 1335 - 1355

Опубликована: Март 31, 2011

Язык: Английский

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Peptide Neuromodulation in Invertebrate Model Systems

Neuron, Год журнала: 2012, Номер 76(1), С. 82 - 97

Опубликована: Окт. 1, 2012

Язык: Английский

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