Molecules,
Год журнала:
2024,
Номер
29(16), С. 3887 - 3887
Опубликована: Авг. 16, 2024
The
Japanese
plum
tree
(Prunus
salicina
Lindl.)
is
mainly
cultivated
in
temperate
areas
of
China
and
some
European
countries.
Certain
amounts
wood
(from
pruning
works)
are
generated
every
year
from
this
crop
worldwide
commercial
significance.
main
objective
work
was
to
value
agricultural
woody
residue,
for
which
the
chemical
composition
extracts
six
cultivars
investigated,
antiproliferative
activity
pure
phenolics
present
those
measured.
For
characterization,
total
phenolic
content
DPPH
radical-scavenging
assays
HPLC‒DAD/ESI‒MS
analyses
were
performed,
with
procyanidin
(−)-ent-epicatechin-(2α→O→7,4α→8)-epicatechin
(5)
propelargonidin
(+)-epiafzelechin-(2β→O→7,4β→8)-epicatechin
(7)
being
major
components
extracts.
Some
quantitative
differences
found
among
cultivars,
proanthocyanidins
ranged
1.50
(cv.
‘Fortune’)
4.44
‘Showtime’)
mg/g
dry
wood.
Regarding
antitumoral
activity,
eight
four
compounds
evaluated
MCF-7
cells
after
48
h
induction,
showing
extract
cv.
‘Songold’
(‒)-annphenone
(3),
best
(IC50:
424
μg/mL
405
μg/mL,
respectively).
Molecules,
Год журнала:
2025,
Номер
30(4), С. 944 - 944
Опубликована: Фев. 18, 2025
Numerous
studies
have
previously
demonstrated
the
antimicrobial
activity
of
plant
extracts
rich
in
procyanidins.
However,
these
investigations
that
focused
on
uncharacterized
do
not
provide
information
structure-activity
relationships
compounds.
The
aim
this
work
was
to
investigate
antibacterial
and
antibiofilm
properties
27
phenolics
with
coumarin,
naphthoquinone
pyranone
moieties
against
foodborne
microorganisms,
as
well
establish
relationships.
Minimal
inhibitory
concentrations
(MICs)
for
each
compound
were
investigated,
their
ability
inhibiting
biofilm
formation
disrupting
formed
biofilms
by
food
pathogens.
Our
compounds
show
high
activities
Gram-positive
bacteria.
Regarding
observed,
coumarin
moiety
seems
favor
both
S.
aureus
strains
assayed,
while
a
enhances
effects
B.
cereus.
Moreover,
replacement
OH
groups
B-ring
methoxy
impairs
target
bacteria,
presence
Cl
or
molecules
enhance
inhibition
disruption
preformed
biofilms.
These
results
may
be
great
relevance
sector,
increasing
options
additives
can
used
industrially.
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 322 - 322
Опубликована: Март 7, 2025
The
aging
population
is
steadily
increasing,
with
and
age-related
diseases
serving
as
major
risk
factors
for
morbidity,
mortality,
economic
burden.
Peanuts,
known
the
"longevity
nut"
in
China,
have
been
shown
to
offer
various
health
benefits,
peanut
skin
extract
(PSE)
emerging
a
key
compound
of
interest.
This
study
investigates
bioactive
PSE
anti-aging
potential
explores
its
underlying
mechanisms
action.
Procyanidin
A1
(PC
A1)
was
isolated
from
PSE,
guided
by
K6001
yeast
replicative
lifespan
model.
PC
prolonged
yeast-like
chronological
PC12
cells.
To
further
confirm
effect,
cellular
senescence,
hallmark
aging,
assessed.
In
senescent
cells
induced
etoposide
(Etop),
alleviated
senescence
reducing
ROS
levels,
decreasing
percentage
cells,
restoring
proliferative
capacity.
Transcriptomics
analysis
revealed
that
apoptosis,
reduced
senescence-associated
secretory
phenotype
(SASP)
factors,
modulated
phosphatidylinositol
3-kinase
(PI3K)/protein
kinase
B
(Akt)
signaling
pathway.
antioxidative
capacity
also
evaluated,
showing
enhanced
resistance
oxidative
stress
reactive
oxygen
species
(ROS)
malondialdehyde
(MDA)
levels
increasing
superoxide
dismutase
(SOD)
activity.
Moreover,
autophagy,
evidenced
an
increase
fluorescence-labeled
autophagic
compartments
confirmation
via
Western
blot
autophagy-related
proteins.
addition,
treatment
autophagy
inhibitor
abolished
senescence-alleviating
effects
A1.
These
findings
reveal
extended
lifespans
enhancing
inducing
positioning
it
promising
candidate
exploration
geroprotective
agent.
Frontiers in Veterinary Science,
Год журнала:
2025,
Номер
12
Опубликована: Март 12, 2025
Proanthocyanidins
(PACs)
are
natural
polyphenolic
compounds
widely
distributed
in
various
plants,
which
mixtures
of
oligomers
and
polymers
formed
by
the
polymerization
different
numbers
catechins
epicatechins.
PACs
exhibit
a
range
biological
activities,
including
antioxidant,
anti-inflammatory,
anti-cancer,
anti-atherosclerotic,
hypoglycemic,
antihypertensive
effects,
as
well
ability
to
regulate
intestinal
flora
promote
fat
metabolism.
These
properties
render
highly
promising
for
applications
food,
pharmaceutical,
cosmetic
industries,
garnering
substantial
interest
from
researchers
globally.
Additionally,
demonstrate
significant
nutritional
benefits
animal
husbandry.
Dietary
can
enhance
growth,
mitigate
oxidative
stress,
decrease
feeding
expenses,
offer
an
environmentally
friendly,
antibiotic-free
alternative.
Therefore,
have
great
application
potential
field
pig
production.
This
article
reviews
basic
properties,
functions,
research
status
production
PACs,
aiming
provide
theoretical
guidance
development
substitute
antibiotic
feed
additives.
