Journal of Affective Disorders, Год журнала: 2023, Номер 327, С. 425 - 438
Опубликована: Фев. 3, 2023
Язык: Английский
Antioxidants, Год журнала: 2022, Номер 11(9), С. 1674 - 1674
Опубликована: Авг. 27, 2022
Mulberry has attracted wide attention due to its substantial nutritional values. This work first studied the protective effect of mulberry anthocyanins (MAS) on dextran sulfate sodium (DSS)-induced colitis. The mice experiment was designed as four groups including normal (Control), (DSS)-fed mice, and DSS plus 100 mg/kg·bw MAS-fed (LMAS-DSS) or 200 (HMAS-DSS). Mice were given MAS by gavage for 1 week, then added drinking water 7 days. administered a total 17 results showed that oral reduced disease activity index (DAI), prevented colon shortening, attenuated tissue damage inflammatory response, suppressed colonic oxidative stress restored protein expression intestinal tight junction (TJ) (ZO-1, occludin claudin-3) in with DSS-induced In addition, analysis 16S rRNA amplicon sequences microbiota dysbiosis, reduction Escherichia-Shigella, an increase Akkermansia, Muribaculaceae Allobaculum. Collectively, alleviates colitis maintaining barrier, modulating cytokines, improving microbial community.
Язык: Английский
Процитировано
75
Gastroenterology, Год журнала: 2023, Номер 166(1), С. 44 - 58
Опубликована: Сен. 20, 2023
The gut microbiota plays a significant role in the pathogenesis of both forms inflammatory bowel disease (IBD), namely, Crohn's (CD) and ulcerative colitis (UC). Although evidence suggests dysbiosis loss beneficial microbial species can exacerbate IBD, many new studies have identified microbes with pathogenic qualities, termed "pathobionts," within intestines patients IBD. concept pathobionts initiating or driving chronicity IBD has largely focused on putative aggravating that adherent invasive Escherichia coli may play CD. However, recent additional bacterial fungal CD UC. This review will highlight characteristics these their implications for treatment. Beyond exploring origins pathobionts, we discuss those associated specific clinical features potential mechanisms involved, such as creeping fat (Clostridium innocuum) impaired wound healing (Debaryomyces hansenii) well increased fecal proteolytic activity (Bacteroides vulgatus) seen biomarker UC severity. Finally, examine impact current therapies, several approaches to target currently early stages development. Despite recognizing likely contribute more work is needed define modes action. Determining whether causal relationships exist between could pave way improved care patients, particularly not responding therapies. incidence diseases (IBD; [CD] [UC]), increasing most industrialized countries.1Ng S.C. Shi H.Y. Hamidi N. et al.Worldwide prevalence 21st century: systematic population-based studies.Lancet. 2017; 390: 2769-2778Abstract Full Text PDF PubMed Scopus (3342) Google Scholar etiology complex, it thought reflect dysregulated immunity develops genetically susceptible individuals after exposure noxious environmental stimuli, including microbes. Genome-wide association than 200 genes2Ye B.D. McGovern D.P.B. Genetic variation IBD: progress, clues possible utility.Expert Rev Clin Microbiol. 12: 1091-1107Google Scholar,3Peters L.A. Perrigoue J. 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Albenberg L. causation correlation?.Nat 14: 573-584Crossref (971) should exercise caution when extrapolating rodent models applying human disease,23Walter Armet Finlay B.B. al.Establishing exaggerating causality microbiome: lessons microbiota-associated rodents.Cell. 180: 221-232Abstract (271) this positive feedback loop unfortunate "recipe" Even so, reflects array intertwined bacterial-host differs based status, baseline microbiota. One popular hypothesis progression, facilitated concomitant commensals24Cococcioni Panelli Varotto-boccazzi I. al.IBDs pediatric age: peculiarities involvement microbiota.Dig 53: 17-25Scopus (7) metabolites, short-chain fatty acid butyrate.25Byndloss M.X. Olsan E.E. 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Identification colitisin children.J Paediatr Child Health. 56: 1731-1734Google acquisition familial peri-natal 2019 had lower detected infant's stool.49Torres assessing consequences, sourced stool, imbalance systems recipient mice. Cells colonic lamina propria showed reduction class-switched memory B immunoglobulin (Ig) A+ regulatory T (mother's stool only).49Torres Also transmission, elevated infants low experienced life correlation composition.50Kim Extending concepts mouse dam neonate resulted adult mice colonized AIEC.53Brand M.W. Hostetter J.M. al.Vertical attaching . neonatal predisposes following colitic insult life.PLoS One. 17e0266005Google Currently, ongoing trial investigating utero mother newborn determine subsequent (ClinicalTrials.gov Identifier: NCT03116568). heritable, large, carefully controlled humans required if acquired infants, promoting Parental transfer families; therefore, discussions approached until validated interventions available. 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Язык: Английский
Процитировано
73
Nature Microbiology, Год журнала: 2023, Номер 8(1), С. 91 - 106
Опубликована: Янв. 5, 2023
Язык: Английский
Процитировано
53
Gut, Год журнала: 2023, Номер 73(1), С. 78 - 91
Опубликована: Авг. 8, 2023
Objective The pathogenesis of sepsis is complex, and the sepsis-induced systemic proinflammatory phase one key drivers organ failure consequent mortality. Akkermansia muciniphila (AKK) recognised as a functional probiotic strain that exerts beneficial effects on progression many diseases; however, whether AKK participates in still unclear. Here, we evaluated potential contribution to lethal development. Design Relative abundance gut microbial septic patients was evaluated. Cecal ligation puncture (CLP) surgery lipopolysaccharide (LPS) injection were employed establish mice. Non-targeted targeted metabolomics analysis used for metabolites analysis. Results We first found relative significantly reduced compared with non-septic controls. Live supplementation, well supplementation its culture supernatant, remarkably mortality models. Metabolomics germ-free mouse validation experiments revealed live able generate novel tripeptide Arg-Lys-His (RKH). RKH exerted protective against death damage. Furthermore, markedly inflammatory cell activation factor overproduction. A mechanistic study could directly bind Toll-like receptor 4 (TLR4) block TLR4 signal transduction immune cells. Finally, validated preventive inflammation damage piglet model. Conclusion tripeptide, RKH, derived from AKK, may act endogenous antagonist TLR4. serve therapeutic approach combat after successfully translating efficacy into clinical practice.
Язык: Английский
Процитировано
48
Journal of Affective Disorders, Год журнала: 2023, Номер 327, С. 425 - 438
Опубликована: Фев. 3, 2023
Язык: Английский
Процитировано
45