Efficient Therapy of Inflammatory Bowel Disease (IBD) with Highly Specific and Durable Targeted Ta₂C Modified with Chondroitin Sulfate (TACS)

Advanced Materials, Год журнала: 2023, Номер 35(36)

Опубликована: Май 24, 2023

Non-invasive localization of lesions and specific targeted therapy are still the main challenges for inflammatory bowel disease (IBD). Ta, as a medical metal element, has been widely used in treatment different diseases because its excellent physicochemical properties but is far from being explored IBD. Here, Ta2 C modified with chondroitin sulfate (CS) (TACS) evaluated highly nanomedicine Specifically, TACS dual targeting CS functions due to IBD lesion-specific positive charges high expression CD44 receptors. Thanks acid stability, sensitive CT imaging function, strong reactive oxygen species (ROS) elimination ability, oral can accurately locate delineate through non-invasive imaging, specifically treat effectively levels ROS central factor progression As expected, much better therapeutic effects than clinical contrast agent first-line drug 5-aminosalicylic acid, respectively. The mechanism mainly involves protection mitochondria, oxidative stress, inhibiting macrophage M1 polarization, intestinal barrier, restoration flora balance. Collectively, this work provides unprecedented opportunities nanomedicines

Язык: Английский

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The progression of inorganic nanoparticles and natural products for inflammatory bowel disease

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Янв. 3, 2024

Abstract There is a growing body of evidence indicating close association between inflammatory bowel disease (IBD) and disrupted intestinal homeostasis. Excessive production reactive oxygen species (ROS) nitrogen (RNS), along with an increase in M1 proinflammatory macrophage infiltration during the activation inflammation, plays pivotal role disrupting homeostasis IBD. The overabundance ROS/RNS can cause tissue damage disruption crucial gut proteins, which ultimately compromises integrity barrier. proliferation macrophages contributes to exaggerated immune response, further compromising Currently, nanomaterials have gained widespread attention context IBD due their notable characteristics, including ability specifically target regions interest, clear excess ROS/RNS, mimic biological enzymes. In this review, we initially elucidated microenvironment Subsequently, delineate therapeutic strategies involving two distinct types nanomedicine, namely inorganic nanoparticles natural product nanomaterials. Finally, present comprehensive overview promising prospects associated application nanomedicine future clinical settings for treatment (graphic abstract). Graphical

Язык: Английский

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Effect of anthocyanins on gut health markers, Firmicutes-Bacteroidetes ratio and short-chain fatty acids: a systematic review via meta-analysis

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Янв. 31, 2023

Abstract Researchers discovered that diets rich in anthocyanin-rich fruits and vegetables significantly impacted gut flora. To conclude, large-scale randomized controlled clinical trials are challenging to conduct; therefore, merging data from multiple small studies may aid. A systematic review collects analyses all research on a particular subject design. This comprehensive meta-analysis examined the influence of dietary anthocyanins Firmicutes/Bacteroide (Fir/Bac) short-chain fatty acids (SCFAs) content. The current followed guidelines PRISMA—the preferred reporting items for reviews meta-analyses. Diets high substantially reduced Fir/Bac ratio assessed trials. Among three SCFAs, highest impact was observed acetic acid, by propionic then butanoic acid. results also obtained sufficient heterogeneity, as indicated I 2 values. There is strong evidence anthocyanin supplementation improves rodent health biomarkers (Fir/Bac SCFAs), reducing obesity-induced dysbiosis, revealed this review/meta-analysis. Anthocyanin intervention duration dosage influenced SCFA. Anthocyanin-rich were more effective when consumed over an extended period at dosage.

Язык: Английский

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Fecal microbiota transplantation alleviates intestinal inflammatory diarrhea caused by oxidative stress and pyroptosis via reducing gut microbiota-derived lipopolysaccharides

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 261, С. 129696 - 129696

Опубликована: Янв. 26, 2024

Язык: Английский

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An Exopolysaccharide from Genistein-Stimulated Monascus Purpureus: Structural Characterization and Protective Effects against DSS-Induced Intestinal Barrier Injury Associated with the Gut Microbiota-Modulated Short-Chain Fatty Acid-TLR4/MAPK/NF-κB Cascade Response

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(13), С. 7476 - 7496

Опубликована: Март 21, 2024

Inflammatory bowel disease is a major health problem that can lead to prolonged damage the digestive system. This study investigated effects of an exopolysaccharide from genistein-stimulated Monascus purpureus (G-EMP) in mouse model colitis clarify its molecular mechanisms and identified structures. G-EMP (Mw = 56.4 kDa) was primarily consisted → 4)-α-D-Galp-(1 →, 2,6)-α-D-Glcp-(1→ →2)-β-D-Manp-(1 , with one branches being α-D-Manp-(1 →. intervention reduced loss body weight, degree colonic shortening, activity index scores, histopathology while restoring goblet cell production oxidative homeostasis, repairing functions, regulating inflammatory cytokines. RNA sequencing Western blot analysis indicated exerts anti-inflammatory properties by suppressing TLR4/MAPK/NF-κB signaling pathway. modulated gut microbiota improving diversities, elevating relative abundances beneficial bacteria, declining Firmicutes/Bacteroidota value, level short-chain fatty acids (SCFAs). Correlation demonstrated strong links between SCFAs, microbiota, response, indicating potential prevent colitis.

Язык: Английский

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Bioavailability of Anthocyanins: Whole Foods versus Extracts

Nutrients, Год журнала: 2024, Номер 16(10), С. 1403 - 1403

Опубликована: Май 7, 2024

Anthocyanins have gained significant popularity in recent years for their diverse health benefits, yet limited bioavailability poses a challenge. To address this concern, technologies emerged to enhance anthocyanin concentration, often isolating these compounds from other food constituents. However, the extent which isolated anthocyanins confer benefits compared whole-food counterparts remains unclear. This review explores current literature on and metabolism body, with focus comparing when consumed as extracts versus whole foods rich anthocyanins, drawing vitro, vivo, human clinical studies. While direct comparisons between isolates are scarce, prevailing evidence favours consumption over extracts. Further investigations, preferably comparisons, needed validate findings elucidate nuanced interplay matrices, informing future research directions practical recommendations.

Язык: Английский

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The role of gut microbiota in the occurrence and progression of non-alcoholic fatty liver disease

Frontiers in Microbiology, Год журнала: 2024, Номер 14

Опубликована: Янв. 5, 2024

Background Non-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic worldwide, and gut microbes are associated with development progression NAFLD. Despite numerous studies exploring changes in NAFLD, there was no consistent pattern changes. Method We retrieved on human fecal microbiota sequenced by 16S rRNA gene amplification NAFLD from NCBI database up to April 2023, re-analyzed them using bioinformatic methods. Results finally screened 12 relevant related which included a total 1,189 study subjects (NAFLD, n = 654; healthy control, 398; obesity, 137). Our results revealed significant decrease microbial diversity occurrence (SMD −0.32; 95% CI −0.42 −0.21; p < 0.001). Alpha increased abundance several crucial genera, including Desulfovibrio , Negativibacillus Prevotella can serve as an indication their predictive risk ability for (all AUC > 0.7). The significantly higher levels LPS biosynthesis, tryptophan metabolism, glutathione lipid metabolism. Conclusion This elucidated relevance identified potential risk-associated functional pathways progression.

Язык: Английский

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The Role of Anthocyanins in Alleviating Intestinal Diseases: A Mini Review

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(11), С. 5491 - 5502

Опубликована: Март 6, 2024

Anthocyanins are phytonutrients with physiological activity belonging to the flavonoid family whose transport and absorption in human body follow specific pathways. In upper gastrointestinal tract, anthocyanins rarely absorbed intact by active transporters, most reaching colon, where bacteria convert them into metabolites. There is mounting evidence that can be used for prevention treatment of intestinal diseases, including inflammatory bowel disease (IBD), irritable syndrome (IBS), colorectal cancer (CRC), through protective function on epithelial barrier, immunomodulation, antioxidants, gut microbiota metabolism. Dietary summarized this comprehensive review respect their classification structure as well mechanisms within tract. Additionally, delves role mechanism treating common diseases. These insights will deepen our understanding potential benefits natural disorders.

Язык: Английский

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Current applications of intestinal organoids: a review

Stem Cell Research & Therapy, Год журнала: 2024, Номер 15(1)

Опубликована: Май 31, 2024

In the past decade, intestinal organoid technology has paved way for reproducing tissue or organ morphogenesis during physiological processes in vitro and studying pathogenesis of various diseases. Intestinal organoids are favored drug screening due to their ability high-throughput cultivation closer resemblance patient genetic characteristics. Furthermore, as disease models, find wide applications diagnostic markers, identifying therapeutic targets, exploring epigenetic mechanisms Additionally, a transplantable cellular system, have played significant role reconstruction damaged epithelium conditions such ulcerative colitis short bowel syndrome, well material exchange metabolic function restoration. The rise interdisciplinary approaches, including organoid-on-chip technology, genome editing techniques, microfluidics, greatly accelerated development organoids. this review, VOSviewer software is used visualize hot co-cited journal keywords trends firstly. Subsequently, we summarized current modeling, screening, regenerative medicine. This will deepen our understanding further explore intestine

Язык: Английский

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Grape seed proanthocyanidin extract alleviates inflammation in experimental colitis mice by inhibiting NF‐κB signaling pathway

Environmental Toxicology, Год журнала: 2024, Номер 39(5), С. 2572 - 2582

Опубликована: Янв. 11, 2024

Abstract Ulcerative colitis (UC) is a complex inflammatory disease of colorectum that induces abnormal immune responses and severely affects the quality life patients. Grape seed proanthocyanidin extract (GSPE) exerts anti‐inflammatory antioxidant functions in many diseases. The objective this study was to investigate potential therapeutic effects underlying mechanisms GSPE UC using dextran sodium sulfate (DSS)‐induced mouse model lipopolysaccharide (LPS)‐stimulated RAW264.7 macrophage model. In study, we found markedly prevented DSS‐induced weight loss colon length shortening mice. Further investigations showed significantly attenuated expression pro‐inflammatory cytokines TNF‐α, IL‐6, IL‐1β, elevated cytokine IL‐10 tissues serum mice by suppressing NF‐κB signaling pathway. Furthermore, LPS‐induced inflammation cells also reversed GSPE. Taken together, our results confirm can ameliorate response experimental via inhibiting This advances research progress on potentially effective strategy for bowel

Язык: Английский

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