Circulation Research,
Год журнала:
2020,
Номер
126(4), С. 533 - 551
Опубликована: Фев. 13, 2020
During
aging,
deterioration
in
cardiac
structure
and
function
leads
to
increased
susceptibility
heart
failure.
The
need
for
interventions
combat
this
age-related
decline
is
becoming
increasingly
urgent
as
the
elderly
population
continues
grow.
Our
understanding
of
aging
general,
limited.
However,
recent
studies
its
prevention
through
like
exercise
have
revealed
novel
pathological
cardioprotective
pathways.
In
review,
we
summarize
findings
concerning
molecular
mechanisms
failure
highlight
a
valuable
experimental
platform
discovery
much-needed
therapeutic
targets
chronic
disease.
FEBS Letters,
Год журнала:
2019,
Номер
593(13), С. 1566 - 1579
Опубликована: Июнь 18, 2019
Cellular
senescence
and
mitochondrial
dysfunction
have
both
been
defined
as
classical
hallmarks
of
the
ageing
process.
Here,
we
review
intricate
relationship
between
two.
In
context
ageing,
it
is
now
well
regarded
that
cellular
a
key
driver
in
onset
number
age‐related
pathologies.
Emerging
evidence
has
pinpointed
mitochondria
one
modulators
development
phenotype,
particularly
pro‐inflammatory
associated
secretory
phenotype
(SASP).
This
focuses
on
contribution
homeostatic
mechanisms,
reactive
oxygen
species
metabolites
programme.
Furthermore,
discuss
emerging
pathways
mitochondrial‐mediated
mechanisms
may
be
influencing
SASP
and,
subsequently,
explore
how
these
exploited
to
open
up
new
therapeutic
avenues.
Cancers,
Год журнала:
2020,
Номер
12(4), С. 822 - 822
Опубликована: Март 29, 2020
For
the
past
two
decades,
cellular
senescence
has
been
recognized
as
a
central
component
of
tumor
cell
response
to
chemotherapy
and
radiation.
Traditionally,
this
form
senescence,
termed
Therapy-Induced
Senescence
(TIS),
was
linked
extensive
nuclear
damage
precipitated
by
classical
genotoxic
chemotherapy.
However,
number
other
forms
therapy
have
also
shown
induce
in
cells
independently
direct
genomic
damage.
This
review
attempts
provide
comprehensive
summary
both
conventional
targeted
anticancer
therapeutics
that
vitro
vivo.
Still,
utility
promoting
therapeutic
endpoint
remains
under
debate.
Since
represents
durable
growth
arrest,
it
might
be
argued
is
desirable
outcome
cancer
therapy.
accumulating
evidence
suggesting
capacity
escape
from
TIS
would
support
an
alternative
conclusion,
provides
avenue
whereby
can
evade
potentially
lethal
action
drugs,
allowing
enter
temporary
state
dormancy
eventually
facilitates
disease
recurrence,
often
more
aggressive
state.
Furthermore,
now
strongly
connected
remodeling,
dormancy,
acquiring
ominous
malignant
phenotypes
accounts
for
several
untoward
adverse
effects
Here,
we
argue
barrier
effective
treatment,
discuss
emerging
efforts
identify
exploit
agents
with
senolytic
properties
strategy
elimination
persistent
residual
surviving
population,
goal
mitigating
tumor-promoting
influence
senescent
thereby
reduce
likelihood
relapse.
Cardiovascular Research,
Год журнала:
2021,
Номер
118(5), С. 1173 - 1187
Опубликована: Май 5, 2021
Abstract
Cellular
senescence
is
a
state
of
irreversible
cell
cycle
arrest
associated
with
ageing.
Senescence
different
cardiac
types
can
direct
the
pathophysiology
cardiovascular
diseases
(CVDs)
such
as
atherosclerosis,
myocardial
infarction,
and
fibrosis.
While
age-related
telomere
shortening
represents
major
cause
replicative
senescence,
senescent
also
be
induced
by
oxidative
stress,
metabolic
dysfunction,
epigenetic
regulation,
among
other
stressors.
It
critical
that
we
understand
molecular
pathways
lead
to
cellular
consequences
in
order
develop
new
therapeutic
approaches
treat
CVD.
In
this
review,
discuss
mechanisms
explore
how
(including
cardiomyocytes,
endothelial
cells,
fibroblasts,
vascular
smooth
muscle
valve
interstitial
cells)
CVD,
highlight
potential
target
prevent
or
Cells,
Год журнала:
2020,
Номер
9(3), С. 671 - 671
Опубликована: Март 10, 2020
Senescent
cells
are
generally
characterized
by
permanent
cell
cycle
arrest,
metabolic
alteration
and
activation,
apoptotic
resistance
in
multiple
organs
due
to
various
stressors.
Excessive
accumulation
of
senescent
numerous
tissues
leads
chronic
diseases,
tissue
dysfunction,
age-related
diseases
organ
ageing.
Immune
can
remove
cells.
Immunaging
or
impaired
innate
adaptive
immune
responses
result
persistent
Although
senolytics—drugs
that
selectively
inducing
their
apoptosis—are
recent
hot
topics
making
significant
research
progress,
senescence
immunotherapies
using
cell-mediated
clearance
emerging
promising
strategies
fight
ageing
diseases.
This
short
review
provides
an
overview
the
progress
date
concerning
cell-caused
ageing,
as
well
regulation
small-molecule
drugs
clinical
trials
different
roles
elimination
Mounting
evidence
indicates
immunotherapy
targeting
combats
subsequently
extends
healthy
lifespan.
