Cellular Signalling, Год журнала: 2023, Номер 108, С. 110698 - 110698
Опубликована: Май 4, 2023
Язык: Английский
Cellular Signalling, Год журнала: 2023, Номер 108, С. 110698 - 110698
Опубликована: Май 4, 2023
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Окт. 14, 2024
Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against
Язык: Английский
Процитировано
75Aging Cell, Год журнала: 2023, Номер 22(6)
Опубликована: Март 8, 2023
Abstract Ferroptosis is an iron‐dependent cell death that has been found to aggravate the progression of osteoarthritis (OA) and gut microbiota‐ OA axis refers bidirectional information network between microbiota OA, which may provide a new way protect OA. However, role microbiota‐derived metabolites in ferroptosis‐relative remains unclear. The objective this study was analyze protective effect its metabolite capsiate (CAT) on vivo vitro experiments. From June 2021 February 2022, 78 patients were evaluated retrospectively divided into two groups: health group ( n = 39) 40). Iron oxidative stress indicators determined peripheral blood samples. And then experiments, surgically destabilized medial meniscus (DMM) mice model established treated with CAT or Ferric Inhibitor‐1 (Fer‐1). Solute Carrier Family 2 Member 1 (SLC2A1) short hairpin RNA (shRNA) utilized inhibit SLC2A1 expression. Serum iron increased significantly but total binding capacity decreased than healthy people p < 0.0001). least absolute shrinkage selection operator clinical prediction suggested serum iron, capacity, transferrin, superoxide dismutase all independent predictors 0.001). Bioinformatics results SLC2A1, Metastasis‐Associated Lung Adenocarcinoma Transcript (MALAT1), HIF‐1α (Hypoxia Inducible Factor Alpha)‐related signaling pathways play important homeostasis In addition, 16s sequencing untargeted metabolomics used find negatively correlated Osteoarthritis Research Society International (OARSI) scores for chondrogenic degeneration 0.0017). Moreover, reduced ferroptosis‐dependent vitro. against could be eliminated by silencing SLC2A1. upregulated levels DMM group. HIF‐1α, MALAT1, apoptosis after knockout chondrocyte cells Finally, downregulation expression Adeno‐associated Virus (AAV) ‐SLC2A1 shRNA improves vivo. Our findings indicated inhibited HIF‐1a activating
Язык: Английский
Процитировано
61Journal of Dental Research, Год журнала: 2024, Номер 103(7), С. 712 - 722
Опубликована: Май 20, 2024
Inflammation and loss of articular cartilage are considered the major cause temporomandibular joint osteoarthritis (TMJOA), a painful condition (TMJ). To determine TMJ in these patients, synovial fluid TMJOA patients was compared prior to after hyaluronic lavage, revealing substantially elevated levels interleukin (IL) 1β, reactive oxidative stress (ROS), an overload Fe
Язык: Английский
Процитировано
18Journal of Advanced Research, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
The aim of this study was to investigate the potential molecular mechanisms by which taurine protects against cartilage degeneration. anterior cruciate ligament transection (ACLT) surgery used construct an animal model osteoarthritis (OA). Metabolomics identify characteristic metabolites in osteoarthritic chondrocytes. Transcriptomics and metabolomics were explore small molecule metabolite inflammatory chondrocyte damage. Cell transfection inhibitors/agonists validate chondrocytes vitro. Finally, adeno-associated virus degeneration vivo. Metabolomic assays identified as a possible key metabolic progression OA. revealed that O-GlcNAc transferase (OGT)-dependent O-GlcNAcylation Gpx4-dependent ferroptosis may mediate protective effects on chondrocytes, further confirmed gain loss function Subsequently, experiments indicated existence direct binding site for Gpx4 OGT proteins, provides evidence presence modification protein. Finnaly, we demonstrated OGT-dependent be Antioxidant inhibits through upregulation OGT/Gpx4 signaling. Supplementation with taurine, safe nonessential amino acid, therapeutic strategy
Язык: Английский
Процитировано
5Advances in Nutrition, Год журнала: 2025, Номер unknown, С. 100376 - 100376
Опубликована: Янв. 1, 2025
Aging is associated with the decline of tissue and cellular functions, which can promote development age-related diseases like cancer, cardiovascular disease, neurodegeneration, disorders musculoskeletal immune systems. Healthspan length time an individual in good health free from chronic disabilities aging. Two modifiable factors that influence healthspan, healthy aging, prevent diseases, are diet microbiota gastrointestinal tract (gut microbiota). This review will discuss how dietary phytochemicals gut work concert to a First overview provided influences aging through its impact on barrier integrity, function, mitochondria function oxidative stress. Next, mechanisms by effect health, inflammation, nurture diverse microbial composition discussed. Lastly, directly producing bioactive metabolites food urolithin A, equol, hesperetin sulforaphane. These other phytochemical derived may healthspan Importantly, individual's capacity produce promoting cruciferous vegetables, berries, nuts, citrus soy products be dependent specific bacteria present gut.
Язык: Английский
Процитировано
4Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107649 - 107649
Опубликована: Фев. 1, 2025
The joint dysfunction caused by osteoarthritis (OA) is increasingly becoming a major challenge in global healthcare, and there currently no effective strategy to prevent the progression of OA. Therefore, better elucidating relevant mechanisms OA occurrence development will provide theoretical basis for formulating new prevention control strategies. Due long-term exposure cartilage tissue hypoxic microenvironment joints, metabolic reprogramming changes occur. Hypoxia-inducible factor-1alpha (HIF-1α), as core gene regulating hypoxia response vivo, plays an important regulatory role metabolism chondrocytes. HIF-1α adapts such glycolysis, oxidative phosphorylation (OXPHOS), amino acid metabolism, lipid In addition, also regulates macrophage polarization synovial inflammation, chondrocytes degeneration extracellular matrix (ECM) degradation, subchondral bone remodeling angiogenesis OA, affects pathophysiological Consequently, regulation has become therapeutic target this article reviews mechanism affecting chondrocyte reprogramming, focusing on summarizes potential ingredients or targets targeting order more beneficial treatment clinical drugs.
Язык: Английский
Процитировано
3Gut Microbes, Год журнала: 2023, Номер 15(2)
Опубликована: Окт. 5, 2023
Ferroptosis is a distinctive form of iron-dependent necrotic cell death, characterized by excessive lipid peroxidation on cellular membranes and compromised antioxidant defenses. Multiple metabolic pathways, including iron metabolism, as well systems, contribute to the execution ferroptosis. The gut microbiota exerts regulatory effects ferroptosis through its microbial composition, biological functions, metabolites. Notably, most pathogenic bacteria tend promote ferroptosis, thereby inducing or exacerbating diseases, while probiotics have been shown protect against death. Given colonization in gut, an intimate association found between intestinal diseases microbiota. This review consolidates essential aspects ferroptotic processes, emphasizing key molecules delineating intricate interplay Moreover, this underscores potential utility modulation regulating for treatment diseases.
Язык: Английский
Процитировано
25AJP Cell Physiology, Год журнала: 2024, Номер 326(3), С. C724 - C741
Опубликована: Янв. 15, 2024
This study demonstrated for the first time that paeoniflorin (PA) exerts protective effects in diabetic cardiomyopathy mice by alleviating myocardial damage, resisting ferroptosis, and changing community composition structure of intestinal microbiota, 11,12-epoxyeicosatrienoic acid (11,12-EET) may serve as a key contributor its therapeutic efficacy.
Язык: Английский
Процитировано
11World Journal of Microbiology and Biotechnology, Год журнала: 2025, Номер 41(3)
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1Cell Death Discovery, Год журнала: 2024, Номер 10(1)
Опубликована: Май 15, 2024
Abstract Ferroptosis is a novel form of lipid peroxidation-driven, iron-dependent programmed cell death. Various metabolic pathways, including those involved in and iron metabolism, contribute to ferroptosis regulation. The gut microbiota not only supplies nutrients energy the host, but also plays crucial role immune modulation balance. In this review, we explore pathways associated with impact on host metabolism. We subsequently summarize recent studies influence regulation by discuss potential mechanisms through which affects ferroptosis. Additionally, conduct bibliometric analysis relationship between context chronic kidney disease. This can provide new insights into current research status future microbiota.
Язык: Английский
Процитировано
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