Population genetics reveal potential threats from low maternal genetic diversity in wild Asian elephants in China
Global Ecology and Conservation,
Год журнала:
2025,
Номер
unknown, С. e03503 - e03503
Опубликована: Фев. 1, 2025
Язык: Английский
Natural resistance to cancers in long-lived mammals: genomic mechanisms and experimental evidence to explain Peto’s paradox
Science China Life Sciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 21, 2025
Язык: Английский
Rapid evolution of genes with anti-cancer functions during the origins of large bodies and cancer resistance in elephants
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 29, 2024
Elephants
have
emerged
as
a
model
system
to
study
the
evolution
of
body
size
and
cancer
resistance
because,
despite
their
immense
size,
they
very
low
prevalence
cancer.
Previous
studies
found
that
duplication
tumor
suppressors
at
least
partly
contributes
anti-cancer
cellular
phenotypes
in
elephants.
Still,
many
other
mechanisms
must
contributed
augmented
resistance.
Here,
we
use
suite
codon-based
maximum-likelihood
methods
dataset
13,310
protein-coding
gene
alignments
from
261
Язык: Английский
Chromosome‐level Asian elephant genome assembly and comparative genomics of long‐lived mammals reveal the common substitutions for cancer resistance
Aging Cell,
Год журнала:
2023,
Номер
22(9)
Опубликована: Июль 3, 2023
Abstract
The
naked
mole
rat
(
Heterocephalus
glaber
),
bats
(e.g.,
genus
Myotis
and
elephants
(family
Elephantidae)
are
known
as
long‐lived
mammals
assumed
to
be
excellent
cancer
antagonists.
However,
whether
there
common
genetic
changes
underpinning
resistance
in
these
species
is
yet
fully
established.
Here,
we
newly
generated
a
high‐quality
chromosome‐level
Asian
elephant
Elephas
maximus
)
genome
identified
that
the
expanded
gene
families
involved
Ras‐associated
base
excision
repair
pathways.
Moreover,
performed
comparative
genomic
analyses
of
12
examined
genes
with
signatures
positive
selection
elephants,
rat,
greater
horseshoe
bat.
Residues
at
positively
selected
sites
CDR2L
ALDH6A1
enhanced
inhibition
tumor
cell
migration
compared
those
short‐lived
relatives.
Overall,
our
study
provides
new
resource
preliminary
survey
mammals.
Язык: Английский
Myosin-5a facilitates stress granule formation by interacting with G3BP1
Cellular and Molecular Life Sciences,
Год журнала:
2024,
Номер
81(1)
Опубликована: Окт. 10, 2024
Stress
granules
(SGs)
are
non-membranous
organelles
composed
of
mRNA
and
proteins
that
assemble
in
the
cytosol
when
cell
is
under
stress.
Although
composition
mammalian
SGs
both
cell-type
stress-dependent,
they
consistently
contain
core
components,
such
as
Ras
GTPase
activating
protein
SH3
domain
binding
1
(G3BP1).
Upon
stress,
living
cells
rapidly
micrometric
SGs,
sometimes
within
a
few
minutes,
suggesting
SG
components
may
be
actively
transported
by
microtubule
and/or
actin
cytoskeleton.
Indeed,
assembly
has
been
shown
to
depend
on
cytoskeleton
associated
motor
proteins.
However,
role
myosin
remains
controversial.
Here,
we
identified
G3BP1
novel
unconventional
myosin-5a
(Myo5a).
uses
its
C-terminal
RNA-binding
interact
with
middle
portion
Myo5a
tail
(Myo5a-MTD).
Suppressing
function
cells,
either
overexpressing
Myo5a-MTD,
eliminating
gene
expression,
or
treatment
myosin-5
inhibitor,
inhibits
arsenite-induced
formation
small
large
SGs.
This
different
from
effect
disruption,
which
abolishes
but
enhances
stress
conditions.
We
therefore
propose
that,
conditions,
facilitates
at
an
earlier
stage
than
microtubule-dependent
process.
Язык: Английский