Aging in the dermis: Fibroblast senescence and its significance

Aging Cell, Год журнала: 2023, Номер 23(2)

Опубликована: Дек. 1, 2023

Abstract Skin aging is characterized by changes in its structural, cellular, and molecular components both the epidermis dermis. Dermal distinguished reduced dermal thickness, increased wrinkles, a sagging appearance. Due to intrinsic or extrinsic factors, accumulation of excessive reactive oxygen species (ROS) triggers series events, including imbalanced extracellular matrix (ECM) homeostasis, senescent fibroblasts, loss cell identity, chronic inflammation mediated senescence‐associated secretory phenotype (SASP). These events are regulated signaling pathways, such as nuclear factor erythroid 2‐related 2 (Nrf2), mechanistic target rapamycin (mTOR), transforming growth beta (TGF‐β), insulin‐like 1 (IGF‐1). Senescent fibroblasts can induce accelerate age‐related dysfunction other skin cells may even cause systemic inflammation. In this review, we summarize role cutaneous Moreover, underlying mechanisms which influence also discussed.

Язык: Английский

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Impact of Vitamin D on Skin Aging, and Age-Related Dermatological Conditions

Frontiers in Bioscience-Landmark, Год журнала: 2025, Номер 30(1)

Опубликована: Янв. 20, 2025

Human skin is a physical and biochemical barrier that protects the internal body from external environment. Throughout person’s life, undergoes both intrinsic extrinsic aging, leading to microscopic macroscopic changes in its morphology. In addition, repair processes slow with making older population more susceptible diseases. Intrinsic factors associated advanced age gradually degrade dermal collagen matrix, resulting fine wrinkles reduced elasticity; this accelerated post-menopausal women due estrogen deficiency. contrast, age, primarily caused by exposure ultraviolet (UV) radiation, lead coarse wrinkles, solar elastosis, hyperkeratosis, irregular pigmentation, cancers. UVB while contributing photo-aging, also induces cutaneous synthesis of vitamin D. Vitamin D, turn, oxidative stress, inflammation, DNA damage, thereby delaying chronological photo-aging. Moreover, research has demonstrated an association between lower D levels higher prevalence certain This review explores summarizes critical role aging age-related The data presented highlight importance maintaining adequacy throughout life.

Язык: Английский

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The Role of Fibroblasts in Skin Homeostasis and Repair

Biomedicines, Год журнала: 2024, Номер 12(7), С. 1586 - 1586

Опубликована: Июль 17, 2024

Fibroblasts are typical mesenchymal cells widely distributed throughout the human body where they (1) synthesise and maintain extracellular matrix, ensuring structural role of soft connective tissues; (2) secrete cytokines growth factors; (3) communicate with each other cell types, acting as signalling source for stem niches; (4) involved in tissue remodelling, wound healing, fibrosis, cancer. This review focuses on developmental heterogeneity dermal fibroblasts, their ability to sense changes biomechanical properties surrounding aging, skin repair, pathologic conditions tumour development. Moreover, we describe use fibroblasts different models (e.g., vivo animal vitro systems from 2D 6D cultures) bioengineering informative potential high-throughput assays study under disease contexts personalized healthcare regenerative medicine applications.

Язык: Английский

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Research Progress in Skin Aging and Immunity

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 4101 - 4101

Опубликована: Апрель 7, 2024

Skin aging is a complex process involving structural and functional changes characterized by decrease in collagen content, reduced skin thickness, dryness, the formation of wrinkles. This underpinned multiple mechanisms including free radical theory, inflammation photoaging metabolic theory. The immune system, an indispensable part body’s defense mechanism, comprises macrophages, lymphocytes, dendritic cells, mast cells. These cells play pivotal role maintaining homeostasis responding to injury or infection. As age advances, along with various internal external environmental stimuli, may undergo senescence accelerated aging, cell division capability, increased mortality, gene expression patterns signaling pathways, altered functions. collectively impact overall function system. review summarizes relationship between immunity explores characteristics composition effects these on aging. Immune dysfunction plays significant suggesting that immunoregulation become one important strategies for prevention treatment

Язык: Английский

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Deciphering the fibrotic process: mechanism of chronic radiation skin injury fibrosis

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Фев. 15, 2024

This review explores the mechanisms of chronic radiation-induced skin injury fibrosis, focusing on transition from acute radiation damage to a fibrotic state. It reviewed cellular and molecular responses radiation, highlighting role myofibroblasts significant impact Transforming Growth Factor-beta (TGF-β) in promoting fibroblast-to-myofibroblast transformation. The delves into epigenetic regulation gene expression, contribution extracellular matrix proteins microenvironment, immune system context fibrosis. Additionally, it discusses potential biomaterials artificial intelligence medical research advance understanding treatment suggesting future directions involving bioinformatics personalized therapeutic strategies enhance patient quality life.

Язык: Английский

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Combined dasatinib and quercetin treatment contributes to skin rejuvenation through selective elimination of senescent cells in vitro and in vivo

Biogerontology, Год журнала: 2024, Номер 25(4), С. 691 - 704

Опубликована: Апрель 15, 2024

Язык: Английский

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Sauchinone Ameliorates Senescence Through Reducing Mitochondrial ROS Production

Antioxidants, Год журнала: 2025, Номер 14(3), С. 259 - 259

Опубликована: Фев. 24, 2025

One of the major causes senescence is oxidative stress caused by ROS, which mainly generated from dysfunctional mitochondria. Strategies to limit mitochondrial ROS production are considered important for reversing senescence, but effective approaches reduce them have not yet been developed. In this study, we screened secondary metabolites that plants produce under and discovered sauchinone as a potential candidate. Sauchinone induced function recovery, enabling efficient electron transport within chain (ETC). This led decrease in production, byproduct inefficient transport. The reduction rejuvenated senescence-associated phenotypes. To understand underlying mechanism rejuvenates carried out RNA sequencing found VAMP8 key gene. was downregulated sauchinone. Knockdown decreased levels subsequently function, similar effect Taken together, these studies revealed novel reduces regulating expression. Our results open new avenue aging research control production.

Язык: Английский

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Cellular senescence: from homeostasis to pathological implications and therapeutic strategies

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 3, 2025

Cellular aging is a multifactorial and intricately regulated physiological process with profound implications. The interaction between cellular senescence cancer complex multifaceted, can both promote inhibit tumor progression through various mechanisms. M6A methylation modification regulates the of cells tissues by modulating senescence-related genes. In this review, we comprehensively discuss characteristics senescence, signaling pathways regulating biomarkers mechanisms anti-senescence drugs. Notably, review also delves into interactions cancer, emphasizing dual role senescent microenvironment in initiation, progression, treatment. Finally, thoroughly explore function mechanism m6A revealing its critical gene expression maintaining homeostasis. conclusion, provides comprehensive perspective on molecular biological significance offers new insights for development strategies.

Язык: Английский

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Antigen-presenting fibroblasts: emerging players in immune modulation and therapeutic targets

Theranostics, Год журнала: 2025, Номер 15(8), С. 3332 - 3344

Опубликована: Фев. 18, 2025

Antigen-presenting fibroblasts are a newly recognized subset that challenges the traditional view of these cells as mere structural components. Under pathological or environmental stimuli, acquire antigen-presenting capabilities through expression MHC-II molecules and co-stimulatory factors, enabling them to interact with T modulate immune responses. These specialized have been identified across various tissues diseases, where they play context-dependent roles, either amplifying dysregulation contributing homeostasis. This review synthesizes recent advances in understanding origins, activation, functions fibroblasts. It highlights their role promoting pathogenic responses offering therapeutic opportunities targeted modulation. Advancing our holds great promise for developing innovative approaches modulation therapy range diseases.

Язык: Английский

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Effectiveness of Extracellular Vesicle Application in Skin Aging Treatment and Regeneration: Do We Have Enough Evidence from Clinical Trials?

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2354 - 2354

Опубликована: Март 6, 2025

In recent years, there has been a dynamic development in therapies utilizing extracellular vesicles (EVs) including exosomes. Therefore, we have conducted an analysis of the scientific literature to verify current state knowledge about these therapies. A total 12 clinical studies were analyzed, covering use EVs treating skin aging, acne scars, alopecia, and wound healing. The results indicate that exosomes hold potential regenerative therapies, offering innovative non-invasive therapeutic approaches. At same time, significant challenges related standardization their production lack large-scale randomized identified. Thus, also evaluated investigated trials regard MISEV (Minimal Information for Studies Extracellular Vesicles) criteria. This review provides comprehensive overview contemporary applications therapy medicine, highlighting directions further research.

Язык: Английский

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