Head and Neck Pathology, Год журнала: 2024, Номер 18(1)
Опубликована: Окт. 14, 2024
Язык: Английский
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Май 20, 2024
Skin wound healing is a complex and tightly regulated process. The frequent occurrence reoccurrence of acute chronic wounds cause significant skin damage to patients impose socioeconomic burdens. Therefore, there an urgent requirement promote interdisciplinary development in the fields material science medicine investigate novel mechanisms for healing. Cerium oxide nanoparticles (CeO 2 NPs) are type nanomaterials that possess distinct properties have broad application prospects. They recognized their capabilities enhancing closure, minimizing scarring, mitigating inflammation, exerting antibacterial effects, which has led prominence care research. In this paper, distinctive physicochemical CeO NPs most recent synthesis approaches discussed. It further investigates therapeutic process Following that, review critically examines previous studies focusing on effects Finally, it suggests potential cerium as innovative nanomaterial diverse discusses its prospects future advancements.
Язык: Английский
Процитировано
20
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Авг. 2, 2024
Cerium oxide nanoparticles (CeNPs) have emerged as a potent therapeutic agent in the realm of wound healing, attributing their efficacy predominantly to exceptional antioxidant properties. Mimicking activity endogenous enzymes, CeNPs alleviate oxidative stress and curtail generation inflammatory mediators, thus expediting healing process. Their application spans various disease models, showcasing potential treating responses infections, particularly stress-induced chronic wounds such diabetic ulcers, radiation-induced skin injuries, psoriasis. Despite promising advancements laboratory studies, clinical translation is challenged by several factors, including biocompatibility, toxicity, effective drug delivery, development multifunctional compounds. Addressing these challenges necessitates CeNP synthesis functionalization, novel nano delivery systems, comprehensive bio effectiveness safety evaluations. This paper reviews progress highlighting mechanisms, applications, challenges, future perspectives therapeutics.
Язык: Английский
Процитировано
9
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(11), С. 5022 - 5022
Опубликована: Май 23, 2025
Radiotherapy (RT) is a treatment method commonly used in oncology. A vast majority of patients undergoing RT suffer from radiation-induced skin injury (RISI), which results complex biochemical reactions the irradiated skin. Current strategies for preventing and managing RISI are insufficient achieving full regeneration. Multiple studies have shown that alterations microbiome correlate with development severity RISI. These suggest dysbiosis crucial factor promoting radiation-associated dermatitis. Targeting microbiota presents potential therapeutic approach could significantly improve quality life RT. This review aims to present current findings on interplay between damage as well discuss mitigating this condition.
Язык: Английский
Процитировано
0
International Immunopharmacology, Год журнала: 2024, Номер 137, С. 112516 - 112516
Опубликована: Июнь 20, 2024
Язык: Английский
Процитировано
3
Current Opinion in Oncology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 24, 2025
Purpose of review Supportive care plays a vital role in the management head and neck cancer (HNC) patients, as disease often affects frail older population that is treated with multiple strategies associated severe symptoms. We will focus on mucositis, dermatitis, dysphagia, pain, cachexia, infections, they are among most common challenging symptoms encountered. Recent findings Efforts have focused multiomics approaches to decipher complex biological pathways drive symptom onset treatment-related toxicities, aim developing novel therapeutic strategies. A notable example ponsegromab, monoclonal antibody designed target cachexia. Other promising areas research, such machine-learning models oral gut microbiota cachexia actively being explored; however, their impact date remains limited. Summary In recent years, new knowledge has emerged regarding underlying causes predictive for supportive HNC patients. Unfortunately, this expanding body primarily adds complexity without translating into practical applications or substantial improvements Future efforts should prioritize standardization algorithms, generation robust evidence based existing preclinical models.
Язык: Английский
Процитировано
0
Cancers, Год журнала: 2025, Номер 17(7), С. 1108 - 1108
Опубликована: Март 26, 2025
Head and neck cancer encompasses a diverse group of malignant neoplasms originating in regions such as the oral cavity, oropharynx, hypopharynx, larynx, sinonasal cavities, salivary glands. HNC represents significant public health challenge, recent reports indicate an increment incidence young adults. In 2020, approximately 377,700 new cases 177,800 HNC-related deaths were reported globally. Major risk factors include tobacco smoking, alcohol consumption, human papillomavirus (HPV) infections. impacts vital functions breathing, swallowing, speech. Treatments for this type within complex anatomy surgery, radiotherapy, chemotherapy combinations. Radiotherapy is often essential component both curative palliative treatment, balancing tumor control with preservation function appearance. However, its use can damage adjacent normal tissues, causing acute or chronic toxicity. One complication irradiation VF fibrosis, which leads to severe voice impairments, significantly affecting patients' quality life. Fibrosis involves excessive aberrant deposition extracellular matrix, driven by TGF-β1 inflammatory cytokines, ultimately impair flexibility VF. Current radiation-induced fibrosis treatments primarily focus on symptom management systemic therapies like corticosteroids, anti-inflammatory drugs, antioxidants. these have limited efficacy. Experimental approaches targeting molecular pathways involved are being explored. Given limitations treatments, advancing research crucial develop more effective therapeutic strategies that improve life patients, especially those vulnerable fibrosis.
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Май 12, 2025
Background Radiation-induced skin injury (RISI) is a notable complication of cancer radiotherapy, impacting patients’ quality life. Existing interventions mainly address symptoms, with limited success in targeting the fundamental mechanisms. Berberine (BBR), bioactive compound recognized for its anti-inflammatory, antioxidant, and anti-fibrotic characteristics, presents compelling option treating RISI. Methods The molecular targets BBR RISI were identified using Swiss Target Prediction GeneCards databases. A protein-protein interaction (PPI) network was then constructed, core screened Cytoscape plug-in. Molecular functions pathways analyzed through GO KEGG pathway enrichment analyses. Proteomic analysis differential protein expression following treatment. docking validated BBR’s binding to PRKACA PIK3CB. Finally, therapeutic efficacy confirmed irradiated cell animal models. Results pivotal modulating linked inflammation, oxidative stress, tissue repair. Protein histology indicates marked increase epithelial migration proliferation markers (KRT14, KRT16) decrease inflammatory (IL6ST, TNFRSF10B). Enrichment like MAPK cascade development highlights role regeneration. confirms stable key PIK3CB, essential inflammation control. Moreover, treatment promoted cells accelerated wound healing Conclusion demonstrates multi-target potential managing by cellular repair processes. These findings provide foundation future clinical studies optimize dosage delivery, aiming improve outcomes
Язык: Английский
Процитировано
0
Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 6877 - 6887
Опубликована: Май 1, 2025
This study investigates IL-33 and IL-25 expression in post-radiation otitis media with effusion (POME), along classic oxidative stress markers (MDA SOD), to investigate radiation-induced its association ILC2-mediated chronic inflammation, providing basis for targeted therapies. Middle ear effusions (MEE) were collected from 35 irradiated nasopharyngeal carcinoma patients (POME, 43 ears) 20 non-irradiated conventional (CCOME, patients. IL-33, IL-25, IL-6, SOD, MDA levels measured by ELISA. Eustachian tube function was evaluated using the Endoscopic Evaluation of Tube (3ET) scoring system. Comparative analysis revealed distinct molecular profiles between POME CCOME, showing significantly reduced (p=0.046) but elevated SOD activity (p=0.015), a non-significant trend toward higher (p=0.083). Temporal demonstrated peak both at 6 months post-radiation. Correlation studies identified significant associations (r=0.391) as well (r=0.483) IL-6 (both p<0.01). Clinically, showed positive correlation 3ET endoscopic scores (r=0.407, p=0.021) following tympanostomy placement (p=0.024). Notably, no direct observed (p>0.05), nor any found allergic comorbidities (all p>0.05). synergistically drive inflammation OME, emerging biomarker radiotherapy-associated dysfunction. The 6-month cytokine surge highlights therapeutic window interventions mitigate long-term complications.
Язык: Английский
Процитировано
0
Life Sciences, Год журнала: 2025, Номер unknown, С. 123788 - 123788
Опубликована: Июнь 1, 2025
Язык: Английский
Процитировано
0
Cells, Год журнала: 2024, Номер 13(12), С. 1067 - 1067
Опубликована: Июнь 19, 2024
Aberrant sialylation with overexpression of the homopolymeric glycan polysialic acid (polySia) was recently reported in fibroblasts from fibrotic skin lesions. Yet, whether such a rise polySia levels or general may be functionally implicated profibrotic activation and their transition to myofibroblasts remains unknown. Therefore, we herein explored inhibition could interfere process fibroblast-to-myofibroblast induced by master mediator transforming growth factor β1 (TGFβ1). Adult human were pretreated competitive pan-sialyltransferase inhibitor 3-Fax-peracetyl-Neu5Ac (3-Fax) before stimulation recombinant TGFβ1, then analyzed for expression, cell viability, proliferation, migratory ability, acquisition myofibroblast-like morphofunctional features. Skin fibroblast TGFβ1 resulted polySia, which effectively blunted 3-Fax pre-administration. Pretreatment efficiently lessened TGFβ1-induced migration, changes morphology, phenotypic functional differentiation into myofibroblasts, as testified significant reduction FAP, ACTA2, COL1A1, COL1A2, FN1 gene α-smooth muscle actin, N-cadherin, FN-EDA protein levels, well reduced contractile capability. Moreover, pre-administered displayed decrease Smad3-dependent canonical signaling. Collectively, our vitro findings demonstrate first time that aberrant increased has role suggest sialyltransferase might offer new therapeutic opportunities against fibrosis.
Язык: Английский
Процитировано
2