Immunity Inflammation and Disease, Год журнала: 2024, Номер 12(12)

Опубликована: Дек. 1, 2024

ABSTRACT Background Rosacea is a common inflammatory skin disorder characterized by frequent facial flushing, erythema, telangiectasia, and papules, with higher incidence observed in individuals aged 30−50 years tendency to decrease the elderly. This age‐related decline drew our attention further explore relationship between rosacea pathogenesis aging. Methods We analyzed of across 8340 without systemic diseases. The effects LL37‐induced rosacea‐like erythema inflammation were evaluated both young mice. Immunofluorescence analysis was performed assess microvessel density, whereas expression levels angiogenesis‐related factors, including matrix metalloproteinases (MMPs) vascular endothelial growth factor α (VEGFα), quantified. Additionally, immune responses assessed at cellular levels. Results Aged mice displayed milder compared their counterparts. revealed density models group. MMPs VEGFα, decreased mice, indicating reduced responsiveness LL37 stimulation. Furthermore, we found that suppressed Th1‐ Th17‐polarized responses, one major pathogenic mechanisms rosacea, response stimulation Conclusion findings suggest impaired angiogenesis attenuated Th1/Th17 underlie incidence.

Язык: Английский